Lack of sex differences in striatal dopamine D2 receptor binding in drug-naive schizophrenic patients: an IBZM-SPECT study.

Abstract:

:Differences in antipsychotic treatment response, clinical course and outcome of schizophrenia could be related to gender-related cerebral differences in anatomy and function. The aim of the study was to assess sex differences in the striatal dopamine D2 receptor binding in 15 drug-naive schizophrenic patients (seven males, eight females) using (123)I-IBZM single photon emission computed tomography. Basal ganglia/frontal cortex (BG/FC) uptake ratios were obtained. No significant differences were found in global, left and right BG/FC ratios or laterality indices between males and females. No correlation was found between BG/FC ratios and age, duration of illness or scores on symptom rating scales. Our data indicate a lack of sex differences in striatal D2 receptor binding in drug-naive schizophrenic patients and do not support previous reports of left lateralized striatal asymmetry in male schizophrenic patients.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Parellada E,Lomeña F,Catafau AM,Bernardo M,Font M,Fernández-Egea E,Pavía J,Gutierrez F

doi

10.1016/j.pscychresns.2003.05.001

subject

Has Abstract

pub_date

2004-01-15 00:00:00

pages

79-84

issue

1

eissn

0165-1781

issn

1872-7123

pii

S0925492703001574

journal_volume

130

pub_type

杂志文章
  • Computed axial brain tomograms in long-term benzodiazepine users.

    abstract::Computed axial brain tomograms were recorded in four groups of subjects: (a) subjects who had never taken benzodiazepines (n = 25); (b) subjects who had taken them in the past for less than a year (n = 9); (c) patients currently taking benzodiazepines (n = 30); and (d) patients who had taken benzodiazepines in the pas...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(93)90037-h

    authors: Moodley P,Golombok S,Shine P,Lader M

    更新日期:1993-08-01 00:00:00

  • Cholesterol, CSF 5-HIAA, violence and intent in suicidal men.

    abstract::Associations between suicide, violent behaviour and both hypocholesterolaemia and low 5-hydroxyindolacetic acid (5-HIAA) in the cerebrospinal fluid (CSF) have been suggested. The relationships between lipids, the serotonergic system, suicidal and aggressive behaviors are complex. We explored relationships between seru...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2008.07.020

    authors: Jokinen J,Nordström AL,Nordström P

    更新日期:2010-06-30 00:00:00

  • Combined ECT and neuroleptic therapy in treatment-refractory schizophrenia: prediction of outcome.

    abstract::There have been scanty reports of the clinical features of schizophrenic patients treated with electroconvulsive therapy (ECT). This prospective study examined clinical characteristics and predictive factors associated with therapeutic outcome. Two hundred and ninety-three patients with refractory schizophrenia were t...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/s0165-1781(01)00321-3

    authors: Chanpattana W,Chakrabhand ML

    更新日期:2001-12-15 00:00:00

  • Doxapram-induced panic attacks and cortisol elevation.

    abstract::Numerous agents with differing biological properties and central nervous system (CNS) effects can induce panic attacks in predisposed individuals. A potential explanation of this finding is that panic disorder patients are more likely to panic than normal control subjects when given a panicogen due to an excessive fea...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2004.10.010

    authors: Gutman DA,Coplan J,Papp L,Martinez J,Gorman J

    更新日期:2005-02-28 00:00:00

  • The psychometric properties of the Life History of Aggression evaluated in patients from a psychiatric emergency setting.

    abstract::Aggression is a major concern in psychiatric units even more so in emergency settings and is prevalent across many mental disorders. Since a prior history of aggression remains a crucial predictor of violence in hospitalized patients, appropriate tools assessing the history of violence are essential to implement manag...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2017.08.031

    authors: Dellazizzo L,Potvin S,Giguère CÉ,Berwald M,Dugré JR,Dumais A,Signature Consortium.

    更新日期:2017-11-01 00:00:00

  • Quality of life after housing first for adults with serious mental illness who have experienced chronic homelessness.

    abstract::This 1-year longitudinal study of adults who have recently transitioned from homelessness to Permanent Supportive Housing (PSH) focuses on quality of life as a primary outcome of interest. Eighty of 103 new tenants participated in structured interviews at the time of entry into their new home and at 12-months post-hou...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2014.07.072

    authors: Henwood BF,Matejkowski J,Stefancic A,Lukens JM

    更新日期:2014-12-15 00:00:00

  • [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia.

    abstract::Deficient inhibitory neurotransmission of gamma-aminobutyric acid (GABA) has been implicated in the pathophysiology of schizophrenia based on postmortem studies. However, in vivo studies have shown predominantly negative or conflicting results. The goal of this study was to better characterize possible changes of the ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/s0925-4927(99)00027-x

    authors: Verhoeff NP,Soares JC,D'Souza CD,Gil R,Degen K,Abi-Dargham A,Zoghbi SS,Fujita M,Rajeevan N,Seibyl JP,Krystal JH,van Dyck CH,Charney DS,Innis RB

    更新日期:1999-10-11 00:00:00

  • Hippocampal and amygdalar volume changes in elderly patients with Alzheimer's disease and schizophrenia.

    abstract::Patients with Alzheimer's disease (AD) and schizophrenia display cognitive, behavioural disturbances and morphological abnormalities. Although these latter reflect progressive neurodegeneration in AD, their significance in schizophrenia is still unclear. We explored the patterns of hippocampal and amygdalar atrophy in...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.pscychresns.2010.12.015

    authors: Prestia A,Boccardi M,Galluzzi S,Cavedo E,Adorni A,Soricelli A,Bonetti M,Geroldi C,Giannakopoulos P,Thompson P,Frisoni G

    更新日期:2011-05-31 00:00:00

  • The relationship between personality disorder traits and reactive versus proactive motivation for aggression.

    abstract::There is a strong link between personality disorders (PDs) and aggression. This is reflected in high prevalence rates of PD diagnoses in forensic samples, and in several diagnostic criteria of PDs directly referring to elevated levels of aggression. Aggression can stem from two distinct types of motivation; reactive o...

    journal_title:Psychiatry research

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.psychres.2015.07.052

    authors: Lobbestael J,Cima M,Lemmens A

    更新日期:2015-09-30 00:00:00

  • An exploratory study of evoked facial affect in adolescent females with anorexia nervosa.

    abstract::The aim of this exploratory study was to investigate facial affect in adolescent females with anorexia nervosa (AN). Evoked facial affect was recorded whilst AN and control participants (n=34) viewed emotional films. Significantly less facial affect was found in AN adolescents, despite reporting no differences in subj...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2014.07.057

    authors: Rhind C,Mandy W,Treasure J,Tchanturia K

    更新日期:2014-12-15 00:00:00

  • The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An update on management of behavioral and psychological symptoms in dementia.

    abstract::Geriatric patients with dementia frequently present with agitation, aggression, psychosis, and other behavioral and psychological symptoms of dementia (BPSD). We present an update of our previously published algorithms for the use of psychopharmacologic agents in these patients taking into account more recent studies ...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审

    doi:10.1016/j.psychres.2020.113641

    authors: Chen A,Copeli F,Metzger E,Cloutier A,Osser DN

    更新日期:2021-01-01 00:00:00

  • Symptom overreporting obscures the dose-response relationship between trauma severity and symptoms.

    abstract::We investigated whether symptom overreporting affects the dose-response relationship between self-reported abuse severity and psychiatric symptoms in two samples. The first sample (N=599) consisted of adults who had previously reported to a public commission that they had been witnesses to or victims of childhood sexu...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2014.03.018

    authors: Merckelbach H,Langeland W,de Vries G,Draijer N

    更新日期:2014-07-30 00:00:00

  • A comparison of xenon-133 and xenon-127 for the determination of regional cerebral blood flow measured by dynamic SPECT.

    abstract::Phantom studies and cerebral blood flow (CBF) measurements in 11 normal subjects at rest were performed by single photon emission tomography (SPECT) with Xe-133 (16 mm full-width at half-maximum [FWHM] collimation) and Xe-127 (16 mm, 12 mm, and 9 mm FWHM collimation). The phantom results clearly illustrated the feasib...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:

    authors: Coppola R,Marenco S,Jones DW,Berman KF,Weinberger DR

    更新日期:1992-11-01 00:00:00

  • Cerebral metabolic pattern in obsessive-compulsive disorder: altered intercorrelations between regional rates of glucose utilization.

    abstract::Correlations between normalized regional cerebral metabolic rates for glucose, determined by positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose, were used to investigate functional associations between pairs of brain regions in 18 adult patients with primary obsessive-compulsive disorder (OCD) of childho...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0925-4927(91)90014-h

    authors: Horwitz B,Swedo SE,Grady CL,Pietrini P,Schapiro MB,Rapoport JL,Rapoport SI

    更新日期:1991-12-01 00:00:00

  • Association analysis of exon III and exon I polymorphisms of the dopamine D4 receptor locus in Mexican psychotic patients.

    abstract::In this study, we investigated whether polymorphisms of the dopamine D4 receptor (DRD4) gene were associated with psychotic symptomatology rather than with a unique diagnosis such as schizophrenia. A number of association studies between the DRD4 gene 48 bp-VNTR polymorphism at exon 3 and psychotic disorders have been...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2006.12.011

    authors: Aguirre AJ,Apiquián R,Fresán A,Cruz-Fuentes C

    更新日期:2007-12-03 00:00:00

  • Epidemiological data on anorexia nervosa in Japan.

    abstract::An epidemiological survey on anorexia nervosa was performed in Japanese hospitals in 1985 and 1992 using a questionnaire. The reported number of patients with anorexia nervosa was 2391 from 732 institutions. From these data, the total number of anorexia nervosa patients treated in 1985 in Japanese hospitals was estima...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(96)02988-5

    authors: Kuboki T,Nomura S,Ide M,Suematsu H,Araki S

    更新日期:1996-04-16 00:00:00

  • Negative affect predicts social functioning across schizophrenia and bipolar disorder: Findings from an integrated data analysis.

    abstract::Most people with a serious mental illness experience significant functional impairment despite ongoing pharmacological treatment. Thus, in order to improve outcomes, a better understanding of functional predictors is needed. This study examined negative affect, a construct comprised of negative emotional experience, a...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2016.06.031

    authors: Grove TB,Tso IF,Chun J,Mueller SA,Taylor SF,Ellingrod VL,McInnis MG,Deldin PJ

    更新日期:2016-09-30 00:00:00

  • Emotion perception in schizophrenia: an eye movement study comparing the effectiveness of risperidone vs. haloperidol.

    abstract::We used a psychophysiological marker of visual attention (the visual scanpath) to investigate the effects of atypical (risperidone) vs. typical (haloperidol) antipsychotic medication on facial emotion perception in schizophrenia (n=28) and healthy control (n=28) groups. Of the schizophrenia subjects, 15 were prescribe...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0165-1781(03)00166-5

    authors: Williams LM,Loughland CM,Green MJ,Harris AW,Gordon E

    更新日期:2003-08-30 00:00:00

  • Prolactin and sodium lactate-induced panic.

    abstract::Sodium lactate infusions reliably induce panic attacks in panic disorder patients but not in normal controls, but the mechanism underlying this response is unknown. We studied the plasma prolactin response to infusion of 0.5 molar sodium lactate in 38 patients with panic disorder or agoraphobia with panic attacks, and...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(89)90046-2

    authors: Hollander E,Liebowitz MR,Cohen B,Gorman JM,Fyer AJ,Papp LA,Klein DF

    更新日期:1989-05-01 00:00:00

  • Differences in facial expressions of four universal emotions.

    abstract::The facial action coding system (FACS) was used to examine recognition rates in 105 healthy young men and women who viewed 128 facial expressions of posed and evoked happy, sad, angry and fearful emotions in color photographs balanced for gender and ethnicity of poser. Categorical analyses determined the specificity o...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2004.07.003

    authors: Kohler CG,Turner T,Stolar NM,Bilker WB,Brensinger CM,Gur RE,Gur RC

    更新日期:2004-10-30 00:00:00

  • Neuropsychological risk indicators for schizophrenia: a preliminary study of female relatives of schizophrenic and bipolar probands.

    abstract::Evidence of subtle neuropsychological deficits in relatives of schizophrenic probands (REL-SZs) suggests that these are risk indicators for schizophrenia, but little is known about whether neuropsychological performance in REL-SZs differs from that in other groups of relatives. We compared neuropsychological function ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/s0165-1781(98)00042-0

    authors: Kremen WS,Faraone SV,Seidman LJ,Pepple JR,Tsuang MT

    更新日期:1998-07-13 00:00:00

  • State-related thalamic changes during antipsychotic treatment in schizophrenia: preliminary observations.

    abstract::Thalamic volumes and psychotic symptoms were assessed during psychotic exacerbation and during antipsychotic drug treatment. Reduction of psychotic symptoms (SAPS) during four weeks of treatment was highly correlated with volumetric expansion as measured by magnetic resonance imaging in both left and right thalamus [r...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/s0925-4927(03)00092-1

    authors: Strungas S,Christensen JD,Holcomb JM,Garver DL

    更新日期:2003-10-30 00:00:00

  • Associations between depression risk, bullying and current smoking among Chinese adolescents: Modulated by gender.

    abstract::This school-based study aimed to investigate the prevalence of being at risk for depression, bullying behavior, and current smoking among Chinese adolescents in order to explore gender differences in the vulnerability of adolescents with these behaviors to develop a smoking habit. A total of 35,893 high school student...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2016.01.027

    authors: Guo L,Hong L,Gao X,Zhou J,Lu C,Zhang WH

    更新日期:2016-03-30 00:00:00

  • Assessment of behavioral and cognitive impulsivity: development and validation of the Lifetime History of Impulsive Behaviors Interview.

    abstract::The construction and initial psychometric evaluation of an interview assessment of clinically significant impulsivity (Lifetime History of Impulsive Behaviors; LHIB) is presented. Personality-disordered and control subjects participated by completing self-report measures of depression, anxiety and social desirability,...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2003.12.021

    authors: Schmidt CA,Fallon AE,Coccaro EF

    更新日期:2004-04-30 00:00:00

  • Deficits in inhibitory executive functions in Klinefelter (47, XXY) syndrome.

    abstract::Klinefelter syndrome (47, XXY) is a sex chromosome aneuploidy associated with mild deficits in cognitive and language functions. Dysfunctions have also been reported in performance of tasks which examine executive functions. However, it is unclear whether the impaired performance is caused or accentuated by problems w...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2011.02.028

    authors: Kompus K,Westerhausen R,Nilsson LG,Hugdahl K,Jongstra S,Berglund A,Arver S,Savic I

    更新日期:2011-08-30 00:00:00

  • Perception of emotion-related conflict in human communications: what are the effects of schizophrenia?

    abstract::Our ability to make sense of emotional cues is of paramount importance for understanding state of mind and communicative intent. However, emotional cues often conflict with each other; this presents a significant challenge for people with schizophrenia. We conducted a theoretical review to determine the extent and typ...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审

    doi:10.1016/j.psychres.2014.07.077

    authors: Mitchell RL,Rossell SL

    更新日期:2014-12-15 00:00:00

  • Effects of acute cortisol administration on response inhibition in patients with major depression and healthy controls.

    abstract::Glucocorticoids (GCs) have repeatedly been shown to impair hippocampus-mediated, declarative memory retrieval and prefrontal cortex-based working memory in healthy subjects. However, recent experimental studies indicated that patients with major depressive disorder (MDD) lack these impairing effects. These missing eff...

    journal_title:Psychiatry research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psychres.2012.12.019

    authors: Schlosser N,Wolf OT,Fernando SC,Terfehr K,Otte C,Spitzer C,Beblo T,Driessen M,Löwe B,Wingenfeld K

    更新日期:2013-10-30 00:00:00

  • Growing up with a father with PTSD: The family emotional climate of the children of Australian Vietnam veterans.

    abstract::A non-clinical sample of male Australian Vietnam veterans, their wives, and adult offspring were interviewed in-person in a national epidemiological study to assess the relationship between the mental ill-health of veterans and the emotional climate of the family while the children were growing up. Veterans were asses...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2018.06.071

    authors: O'Toole BI,Dadds M,Burton MJ,Rothwell A,Catts SV

    更新日期:2018-10-01 00:00:00

  • Neural correlates of emotional recognition memory in schizophrenia: effects of valence and arousal.

    abstract::Schizophrenia patients are often impaired in their memory for emotional events compared with healthy subjects. Investigations of the neural correlates of emotional memory in schizophrenia patients are scarce in the literature. The present study aimed to compare cerebral activations in schizophrenia patients and health...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.pscychresns.2011.05.010

    authors: Lakis N,Jiménez JA,Mancini-Marïe A,Stip E,Lavoie ME,Mendrek A

    更新日期:2011-12-30 00:00:00

  • Impaired mismatch negativity is associated with current functional status rather than genetic vulnerability to schizophrenia.

    abstract::The aim of this study is to investigate whether mismatch negativity (MMN) is associated with functional status or is a state-independent trait for schizophrenia. We assessed MMN in 26 patients with schizophrenia, 20 healthy subjects with high genetic loading, and 48 healthy controls. Repeated measures analysis of vari...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.pscychresns.2014.02.012

    authors: Kim M,Kim SN,Lee S,Byun MS,Shin KS,Park HY,Jang JH,Kwon JS

    更新日期:2014-04-30 00:00:00