Abstract：
:We used a psychophysiological marker of visual attention (the visual scanpath) to investigate the effects of atypical (risperidone) vs. typical (haloperidol) antipsychotic medication on facial emotion perception in schizophrenia (n=28) and healthy control (n=28) groups. Of the schizophrenia subjects, 15 were prescribed risperidone. Visual scanpaths to 'happy', 'sad' and 'neutral' faces were recorded using video-oculography, and concurrent emotion-recognition accuracy was assessed using multiple-option tasks. Compared to control subjects, both schizophrenia subgroups showed a restriction in visual scanning (reduced total fixation number and decreased scanpath length). Haloperidol-treated schizophrenia subjects exhibited an additional and consistent pattern of reduced attention (fixation) to salient features for neutral and happy. By contrast, risperidone-treated subjects showed a relatively greater attention to salient features for these expressions, in which they did not differ from controls. Recognition accuracy for happy and neutral showed a similar lack of impairment. These findings suggest that risperidone may play a specific role in schizophrenia in the ability to attend to salient features, and to integrate this information into an accurate percept for neutral and positive expressions in particular.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Williams LM,Loughland CM,Green MJ,Harris AW,Gordon Edoi
10.1016/s0165-1781(03)00166-5subject
Has Abstractpub_date
2003-08-30 00:00:00pages
13-27issue
1eissn
0165-1781issn
1872-7123pii
S0165178103001665journal_volume
120pub_type
临床试验,杂志文章abstract：:Cognitive theories of depression propose that depressed individuals preferentially attend to negative information and that such cognitive biases constitute important vulnerability and maintenance factors for the disorder. Most studies examined this bias by registration of response latencies. The present study employed...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.04.002
更新日期：2014-08-15 00:00:00
abstract：OBJECTIVE:Paliperidone, a second-generation antipsychotic, has been found to have minimal hepatotoxicity in patients with schizophrenia. However, long-term hepatic outcome in patients with schizophrenia and viral hepatitis remains unclear. METHODS:Data obtained from the Taiwan National Health Insurance Research Databa...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.112597
更新日期：2019-11-01 00:00:00
abstract：:The current study tested a new interpersonal model of disordered eating behaviours, whereby maladaptive schemas and theory of mind decoding (ToM-decoding) were related with disordered eating attitudes (body dissatisfaction) and behaviours (binging/purging and food restriction) through the mediating variable appearance...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.02.065
更新日期：2019-05-01 00:00:00
abstract：:Studies of the association between parental separation in childhood and suicide thoughts and attempts are scarce. The aim of this study is to investigate associations between parental separation/divorce during childhood, and ever having had suicide thoughts and ever having made suicide attempt, adjusting for social ca...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.07.034
更新日期：2015-09-30 00:00:00
abstract：:Cognitive-behavioural therapy (CBT) is the recommended treatment for binge eating, yet many individuals do not recover, and innovative new treatments have been called for. The current study compares traditional CBT with two augmented versions of CBT; schema therapy, which focuses on early life experiences as pivotal i...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2016.04.080
更新日期：2016-06-30 00:00:00
abstract：:The Self-Regulatory Executive Function (s-REF) model assumes that a common set of unhelpful metacognitive beliefs have a central role in predisposition to psychological disorder and the maintenance of symptoms and distress. This research aims to test whether the five unhelpful metacognitive beliefs implicated in the m...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.10.029
更新日期：2016-12-30 00:00:00
abstract：:Despite heritability estimates of 37-69%, research has identified few genetic risk variants for borderline personality disorder (BPD). The present collaborative candidate gene study of 987 BPD cases and 1110 healthy controls found an association between BPD and single nucleotide polymorphism rs12718541 in the dopa dec...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.06.031
更新日期：2014-11-30 00:00:00
abstract：:This study examined the degree to which subclinical obsessive-compulsive symptoms (SOCS) among individuals with Attention Deficit/Hyperactivity Disorder (AD/HD) were associated with response inhibition difficulties on a performance-based test. Participants consisted of 64 adults with AD/HD who completed the Conner׳s C...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.01.034
更新日期：2014-04-30 00:00:00
abstract：:A central program for recruiting "normal" control subjects is examined by considering the yield of subjects who meet criteria for "healthy" as defined by their personal and family histories of mental disorders. Of the 267 applicants, 30.3% have no lifetime diagnoses, 41.2% are currently healthy with a history of menta...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(94)90057-4
更新日期：1994-09-01 00:00:00
abstract：:Computed tomographic (CT) scans of brains of patients with borderline personality disorder and normal volunteers were analyzed for ventricle-brain ratios, third ventricular size, and evidence of frontal lobe atrophy. There were no significant differences between the two groups on any of these measures except for a nar...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(89)90126-1
更新日期：1989-02-01 00:00:00
abstract：:Disruptive behavior disorders (DBD) are among the most commonly diagnosed mental disorders in children and adolescents. Some important characteristics of DBD vary based on the presence or absence of comorbid attention-deficit/hyperactivity disorder (ADHD), which may affect the understanding of and treatment decision-m...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.01.005
更新日期：2012-06-30 00:00:00
abstract：:Wisconsin Card Sorting Test (WCST) performances were studied in 33 patients with obsessive-compulsive disorder (OCD) and 33 age-, sex-, and education-matched normal comparison subjects; the OCD patients were divided into four subgroups on the basis of their symptomatology. Neither the two groups of subjects nor the fo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(95)02670-r
更新日期：1995-09-08 00:00:00
abstract：:Motivation deficits within Schizophrenia Spectrum Disorders (SSDs) are associated with abnormal striatal dopamine responses during reward processing. Eye blink rate (EBR) has been used as a proxy for striatal dopamine; however, it is unclear whether EBR is sensitive to individual differences in amotivation. Amotivatio...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113490
更新日期：2020-12-01 00:00:00
abstract：:It has been reported that the balance between T-helper type 1 (Th1) cytokines and T-helper type 2 (Th2) cytokines plays a role in psychiatric disorders such as bipolar disorder. The T-helper type 3 (Th3) cytokine, which transforming growth factor beta-1 (TGF-beta1), has been shown to modulate the production of Th1 and...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.08.005
更新日期：2004-12-30 00:00:00
abstract：:The lack of social contacts may be an important element in the presumed vicious circle aggravating, or at least stabilising negative symptoms in patients with schizophrenia. A European 2-year cohort study collected negative symptom scores, psychosocial functioning scores, objective social contact frequency scores and ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.11.039
更新日期：2015-12-30 00:00:00
abstract：:Considerable disagreement exists about the neuroanatomical basis of conceptual-semantic impairments observed in a subgroup of patients with Alzheimer's disease (AD) at mild to moderate stages of the disease. Several studies of groups of patients have shown correlations between focal hypometabolism or hypoperfusion in ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2004.07.006
更新日期：2004-12-15 00:00:00
abstract：:The Mood and Anxiety Symptoms Questionnaire (MASQ) was developed to measure the symptom-dimensions of the tripartite model of anxiety and depression. A 30-item short adaptation of the MASQ (MASQ-D30) was previously developed and validated in adult psychiatric outpatients. The aim of the present study was to evaluate t...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.12.018
更新日期：2014-03-30 00:00:00
abstract：:The major aims of this study were to examine how, if at all, having higher levels of PTSD would be associated with performance on a facial affect recognition task in which facial expressions of emotion are superimposed on emotionally valenced, non-face images. College students with trauma histories (N = 90) completed ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.04.055
更新日期：2018-07-01 00:00:00
abstract：:The basal ganglia have received increasing attention with regard to their role in time pacing, motor function and other components of cognition. The aim of this study was to test whether the finer the motor activity and/or time perception performance were, the higher the striatal dopamine D(2) binding would be. Single...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2003.07.002
更新日期：2004-09-15 00:00:00
abstract：:Toxoplasmosis has been previously associated with an increased risk of having schizophrenia in several epidemiological studies. The aim of this prospective study was to examine for the first time a possible association between positive serology to Toxoplasma gondii (T. gondii) and schizophrenia in the Algerian populat...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113293
更新日期：2020-09-01 00:00:00
abstract：:One of the central problems in posttraumatic stress disorder (PTSD) is the inability to suppress fear even under safe conditions. The neural underpinnings of fear are clinically relevant but poorly understood. This study assessed fear potentiation and fear inhibition using fear-potentiated startle in a conditional dis...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.12.014
更新日期：2009-05-15 00:00:00
abstract：:The purpose of this study was to examine factors related to the delivery and effectiveness of psychiatric care prior to and following prison release. Particular attention was placed on patients' self-reported needs, psychiatric medication adherence, and perceived stigma related to mental health treatment, and how thes...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.05.018
更新日期：2019-06-01 00:00:00
abstract：:Obsessive-compulsive disorder (OCD) has been linked to a dysfunction of brain corticostriatal networks, although functional imaging studies of OCD rarely apply network-sensitive analysis methods. In this study, we compared a univariate and a multivariate analysis of PET data in OCD patients and healthy subjects; the l...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2006.03.002
更新日期：2006-10-30 00:00:00
abstract：:Eating disorders (EDs) are characterized by symptoms that reflect disturbed eating habits. Available data on EDs largely reflects a traditional latent variable model, whereby symptoms reflect an underlying entity. The network model is an alternative approach where ED symptoms do not reflect an inferred, unobservable c...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.02.027
更新日期：2018-04-01 00:00:00
abstract：:The primary aim of the present study was to assess the possible associations between dopaminergic, serotonergic, and glutamatergic system-related genes and adverse events after antipsychotic treatment in paranoid schizophrenia patients. The second aim of the study was to compare the intensity of these symptoms between...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2014.05.039
更新日期：2014-10-30 00:00:00
abstract：:Numerous studies have documented a significant association between symptom severity and cognitive functioning in bipolar disorder (BD). These findings advanced speculations about a potential link between the physiological stress associated with illness severity and cognitive dysfunction. To explore this hypothesis, th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.07.059
更新日期：2014-12-30 00:00:00
abstract：:The Pittsburgh Sleep Quality Index (PSQI) is a widely used, comprehensive self-report measure of sleep quality and impairment, which has demonstrated good psychometric properties within various populations, including older adults. However, the psychometric properties of the PSQI and its component scores have not been ...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2012.03.045
更新日期：2012-08-30 00:00:00
abstract：:Intermittent explosive disorder (IED), a disorder characterized by outbursts of affective aggression, is associated with deficits in regulating emotions. However, less is known about specific deficits in understanding and processing emotions in IED. This study sought to fill that gap by examining components of emotion...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.01.046
更新日期：2019-03-01 00:00:00
abstract：:Individuals with schizophrenia (SZ) and individuals with major depressive disorder (MDD) demonstrate impaired emotional memory and decreased enjoyment of pleasant experiences (e.g., anhedonia). However, it is unclear whether these impairments reflect similar or different processes in the two diagnostic groups. This st...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.09.012
更新日期：2015-12-15 00:00:00
abstract：:Persistent infection with Herpes Simplex viruses (HSV) and other brain infections is consistently associated with cognitive impairment. These infections can also affect sleep. Thus, sleep abnormalities could explain the cognitive dysfunction. We investigated the association between sleep variables and persistent HSV-1...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.112502
更新日期：2019-10-01 00:00:00
