Abstract：
:Wisconsin Card Sorting Test (WCST) performances were studied in 33 patients with obsessive-compulsive disorder (OCD) and 33 age-, sex-, and education-matched normal comparison subjects; the OCD patients were divided into four subgroups on the basis of their symptomatology. Neither the two groups of subjects nor the four OCD subgroups differed on any of the WCST neuropsychological indices. No relationship was demonstrated between test performance and clinical-epidemiological characteristics of the OCD patients. All of the OCD patients were being treated with fluvoxamine maleate, which improves OCD symptoms and could also improve WCST performances. Nevertheless, no remarkable differences in the WCST indices were observed in patients treated with fluvoxamine when compared with patients who had not received a specific therapy for at least 3 weeks. Since the WCST is widely considered sensitive to dysfunction of the dorsolateral prefrontal cortex, our results do not support the involvement of that brain region in OCD.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Abbruzzese M,Ferri S,Scarone Sdoi
10.1016/0165-1781(95)02670-rsubject
Has Abstractpub_date
1995-09-08 00:00:00pages
37-43issue
1eissn
0165-1781issn
1872-7123pii
016517819502670Rjournal_volume
58pub_type
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