Abstract：
:Following a drug-free placebo period lasting at least 1 week, 10 female and 11 male newly hospitalized schizophrenic patients received chlorpromazine (CPZ) 200 mg/day for 1 week and 400 mg/day the following week. Serum CPZ equivalent (CPZ-E) levels were measured at the end of each week of CPZ treatment with a radioreceptor assay. Chlorpromazine-E levels were significantly higher in females than males, but this finding could be accounted for by differences in body weight. Serum prolactin (PRL) levels were also higher in females than males. After differences in serum CPZ-E level were adjusted for, females still had significantly higher serum PRL levels than males. Serum PRL levels increased between the first and second treatment weeks in females but not in males. Correlations between serum CPZ-E and PRL levels were higher among males than females. Significant improvement for the patient group as a whole was observed during the 2 weeks of treatment, with a strong trend for females to improve more than males. Clinical outcome at this initial period was not predicted by either serum PRL levels or serum CPZ-E levels.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Meltzer HY,Busch DA,Fang VSdoi
10.1016/0165-1781(83)90001-xsubject
Has Abstractpub_date
1983-08-01 00:00:00pages
271-83issue
4eissn
0165-1781issn
1872-7123pii
0165-1781(83)90001-Xjournal_volume
9pub_type
杂志文章abstract：:Tardive dyskinesia (TD) is a neurological disorder characterized by irregular, non-rhythmic, choreoathetotic and involuntary movements in single or multiple body regions. Chronic administration of typical antipsychotic agents, which predominantly act on dopamine receptors, implicates the dopamine system in susceptibil...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.08.007
更新日期：2007-12-03 00:00:00
abstract：:The relationship between severity of tardive dyskinesia (TD) and the prominence of negative symptoms was assessed in 25 right-handed, medicated schizophrenic patients. TD was quantified using ultrasound detectors and frequency measurement techniques as well as with observer rating scales. Electromechanical studies rev...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(89)90042-5
更新日期：1989-05-01 00:00:00
abstract：:Alteration in the hypothalamic-pituitary-adrenal (HPA) axis occurs in up to 50% of depressed patients and is demonstrated by the failure to suppress cortisol concentrations after dexamethasone administration. Evidence suggesting that these cortisol abnormalities reflect hypothalamic-pituitary dysfunction has been inco...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(82)90056-7
更新日期：1982-08-01 00:00:00
abstract：:The activity of phosphatidylinositol-specific phospholipase C was significantly reduced in platelets obtained from 20 euthymic manic-depressive patients on therapeutic lithium doses (mean blood level 0.85 mEq/l) compared to an age- and sex-matched group of 36 control subjects. The activities of prostaglandin E1-, alum...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90138-2
更新日期：1988-04-01 00:00:00
abstract：:Anhedonia is a symptom that plays a significant role in theories of illness such as depression and schizophrenia. Some previous research suggests that participants who report high levels of social/physical anhedonia also show deficits in both self-report and physiological measures of emotional processing, particularly...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.07.030
更新日期：2006-08-30 00:00:00
abstract：:To investigate the prevalence of obsessive-compulsive disorder (OCD) and obsessive-compulsive symptoms (OCS) and their association with demographic and clinical factors, 92 inpatients with chronic schizophrenia participated in this study. Demographic factors, severity of psychiatric symptoms as determined by Brief Psy...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.08.003
更新日期：2010-10-30 00:00:00
abstract：:The current study examined whether there is a relationship between the dimension of delusion-proneness and performance on the color-word Stroop task. As dysfunction in the anterior cingulate cortex (ACC) has been related to both Stroop task performance and the presence of delusions in various psychiatric populations, ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.09.001
更新日期：2010-01-30 00:00:00
abstract：:Sparse evidence of a co-aggregation of the risk of schizophrenia and bipolar disorder provides support for a shared but nonspecific genetic etiology of bipolar disorder and schizophrenia. Temperaments are conceptualized as trait sub-syndromic conditions of major pathologies. This study set out to test the hypothesis o...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.10.027
更新日期：2015-01-30 00:00:00
abstract：:A number of long-term studies of course and outcome in schizophrenia report that about a fourth of the cases show good clinical and social recovery. However, very few studies have been carried out examining the main characteristics of schizophrenia patients who have fully recovered according to a strict definition of ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(99)00077-3
更新日期：1999-11-08 00:00:00
abstract：:Presynaptic dopamine metabolism was studied in a group of patients with schizophrenia and in an age- and gender-matched normal control group using 6-[(18)F]fluoro-L-DOPA ((18)F-DOPA) and positron emission tomography (PET). Nineteen patients, nine drug-free, 10 on neuroleptics, and 13 normal control subjects underwent ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(00)00064-0
更新日期：2000-11-20 00:00:00
abstract：:Patients with Alzheimer's disease (AD) and schizophrenia display cognitive, behavioural disturbances and morphological abnormalities. Although these latter reflect progressive neurodegeneration in AD, their significance in schizophrenia is still unclear. We explored the patterns of hippocampal and amygdalar atrophy in...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2010.12.015
更新日期：2011-05-31 00:00:00
abstract：:Recent research implicates cognitive processes traditionally linked to anxiety disorders in the maintenance of paranoia. Responsibility beliefs have traditionally been associated with OCD, and recent research suggests they may be transdiagnostic. The present study reports the first data on responsibility beliefs in in...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.10.044
更新日期：2018-01-01 00:00:00
abstract：:The purpose of this study was to determine levels of Distress Tolerance (DT) and to compare levels of DT, depression, and anxiety in the parents of substance dependent patients. This sample included 40 parents of inpatients undergoing treatment for substance dependence (SDPP) in the Balıklı Rum Hospital, Istanbul, Tur...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.12.026
更新日期：2017-05-01 00:00:00
abstract：:Seventy volunteers had 3 nights of sleep recordings during a period of marital separation, and 61 returned for repeat studies 1 year later. At that time, the divorce was final for 42. Forty of the volunteers were depressed when first screened, and 30 were not. Initially all those undergoing marital separation had less...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90088-7
更新日期：1991-12-01 00:00:00
abstract：:It has been suggested that memory impairments found in obsessive-compulsive disorder (OCD) are mediated by organizational problems in encoding that are caused by primary executive dysfunction. Performance on different nonverbal memory and executive skills was tested in 68 subjects (35 non-depressed OCD sufferers and 3...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.09.005
更新日期：2005-01-30 00:00:00
abstract：:The interplay between Callous Unemotional Traits (CU) and Moral Disengagement (MD) was examined in a sample of 90 adolescents with Disruptive Behavior Disorders. Using a person-centered approach, three CU and MD configurations were identified, attesting the strong relationship between these two moral dimensions. Howev...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.043
更新日期：2017-12-01 00:00:00
abstract：:The results of the dexamethasone suppression test (DST) were compared to levels of 24-hour 3-methoxy-4-hydroxyphenylglycol (MHPG) in 60 patients with unipolar depression. DST nonsuppressors had significantly higher levels of MHPG than did DST suppressors. The possible implications of this finding are discussed. ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90065-0
更新日期：1988-05-01 00:00:00
abstract：:This study had three aims: to compare a schizophrenia sample (n = 50) with a substance abuse (n = 25) and normal sample (n = 81) on affect recognition; to compare differences in their performance between positive and negative affect recognition; and to introduce a new videotape method of stimulus presentation. Subject...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(97)00111-x
更新日期：1997-11-14 00:00:00
abstract：:Indirect evidence suggests partially common pathogenetic mechanisms for Neurological Soft Signs (NSS), neurocognition, and social cognition in schizophrenia. However, the possible association between NSS and mentalizing impairments has not yet been examined. In the present study, we assessed the ability to attribute m...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.04.014
更新日期：2014-08-15 00:00:00
abstract：:Depressed mood is prevalent among individuals with schizophrenia, leading to difficulties in functioning. Typically, depressed mood is evaluated using retrospective assessments during which individuals are asked to recall their mood during the past week or month. However, as individuals with schizophrenia may display ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.03.008
更新日期：2015-06-30 00:00:00
abstract：:While cannabis is associated with positive syndrome schizophrenia (SZ), it is unclear whether cannabinoids are also related to negative symptoms such as affective blunting. We examined whether cannabis use is associated with schizotypy and utilized event-related potentials (ERPs) to assess affect processing. Cannabis ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.02.010
更新日期：2008-01-15 00:00:00
abstract：:This study aims to explore the association between bipolar disorder and the risk of gout using a nationwide population-based dataset. We used the 1996-2006 data from the Taiwan National Health Insurance Research Database. The study cohort comprised 24,262 patients who had visited outpatient departments for the treatme...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.07.012
更新日期：2010-12-30 00:00:00
abstract：:To determine the relationship between Tridimensional Personality Questionnaire (TPQ) scales and bulimia nervosa, TPQ scores of 27 bulimic women, age range 21-59, were compared with values for an age-matched sample of 128 normal control women drawn from the national norming sample by Przybeck. Scores for Novelty Seekin...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0165-1781(93)90108-s
更新日期：1993-07-01 00:00:00
abstract：:Cultured fibroblasts were prepared from six normal controls, five DSM-III manic patients, and six DSM-III schizophrenic patients. Lithium (Li+) uptake, 24-hour Li+ ratios, and steady-state membrane potential were measured in these cell lines. The uptake of 10 mM Li+ reached maximum at 2 hours, with an intracellular co...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(88)90114-x
更新日期：1988-06-01 00:00:00
abstract：:Since many psychopathological traits seem to be related to Gambling Disorder (GD), impulsivity, alexithymia and dissociation could play a central role in gambling behaviors, particularly in pathological gambling. We test this hypothesis in four distinct samples of gamblers, three undergoing different types of treatmen...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.10.046
更新日期：2016-12-30 00:00:00
abstract：:The current paper evaluates Criterion B for Non-Suicidal Self-Injury Disorder, which states that non-suicidal self-injury (NSSI) must occur for at least one function. The majority of individuals who engage in NSSI report at least one function, so it is unclear if Criterion B provides diagnostic utility in individuals ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.07.025
更新日期：2016-10-30 00:00:00
abstract：:The aim of this study was to examine associations of major depressive disorder (MDD), its distinct subtypes, and symptom severity with the individual lifestyle factors smoking, diet quality, physical activity, and body mass index as well as with a combined lifestyle index measuring the co-occurrence of these lifestyle...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.08.035
更新日期：2016-11-30 00:00:00
abstract：:No differences in levels of type A monoamine oxidase (MAO) were observed in cultured human skin fibroblasts from nine patients with bipolar depressive illness as compared to 18 age-, sex-, and race-matched controls. All cells were biopsied and cultured under parallel conditions. Fibroblasts from monozygotic twins (thr...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(80)90022-0
更新日期：1980-07-01 00:00:00
abstract：:This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the authors and Editor-in-Chief of the journal. It was brought to the authors' attention that there were several significant data anal...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析,收录出版
doi：10.1016/j.psychres.2015.05.039
更新日期：2015-08-30 00:00:00
abstract：:This study assessed the subjective and cardiovascular effects of relevant doses of cocaine administration during steady-state treatment of the combination of amantadine and baclofen compared to placebo. Participants included 8 healthy, male, cocaine-dependent, non-treatment-seeking individuals (age=36.6+/-5.9; 75% Afr...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.03.012
更新日期：2007-08-30 00:00:00
