Abstract：
:Alteration in the hypothalamic-pituitary-adrenal (HPA) axis occurs in up to 50% of depressed patients and is demonstrated by the failure to suppress cortisol concentrations after dexamethasone administration. Evidence suggesting that these cortisol abnormalities reflect hypothalamic-pituitary dysfunction has been inconsistent. We administered the dexamethasone suppression test to 28 psychiatric inpatients, including 17 cortisol suppressors and 11 nonsuppressors. Adrenocorticotropic hormone (ACTH) concentrations at 8 a.m. pre- and postdexamethasone were significantly greater in cortisol nonsuppressors than in suppressors. Our data support the hypothesis that pituitary ACTH secretion is altered in depressed patients who have HPA axis abnormalities demonstrated by plasma cortisol measurements.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Kalin NH,Weiler SJ,Shelton SEdoi
10.1016/0165-1781(82)90056-7subject
Has Abstractpub_date
1982-08-01 00:00:00pages
87-92issue
1eissn
0165-1781issn
1872-7123pii
0165-1781(82)90056-7journal_volume
7pub_type
杂志文章abstract：:Firefighters represent a unique, vulnerable population at high risk for alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) symptomatology due to the high rates of occupational exposure to traumatic events. To inform specialized alcohol use interventions for firefighters, it is important to understand ...
journal_title：Psychiatry research
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journal_title：Psychiatry research
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pub_type： 临床试验,杂志文章
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更新日期：1986-08-01 00:00:00
abstract：:Psychosis is associated with low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP), a risk factor for cardiovascular events and mortality in the general population. We investigated the relationship between hs-CRP and anthropometric and metabolic changes in first-episode psychosis (FEP) dur...
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
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pub_type： 杂志文章
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更新日期：2014-07-30 00:00:00
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：1995-10-16 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2011-10-30 00:00:00
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journal_title：Psychiatry research
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更新日期：2016-02-28 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2016-02-28 00:00:00
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journal_title：Psychiatry research
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更新日期：2015-02-28 00:00:00
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更新日期：2016-07-30 00:00:00
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journal_title：Psychiatry research
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journal_title：Psychiatry research
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更新日期：2018-04-01 00:00:00
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journal_title：Psychiatry research
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更新日期：2020-10-01 00:00:00
abstract：:The biological underpinnings of sex-related differences in decision-making are still under-explored. The COMT gene is related to sexual dimorphism and with different choices made under uncertainty, albeit no study has specifically investigated a moderation effect of sex on the association between the COMT gene and the...
journal_title：Psychiatry research
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更新日期：2016-12-30 00:00:00
abstract：:Patients with psychosis have been found to suffer from physical illnesses more commonly than the general population. In this report, self-reported physical ill health and its correlates among subjects with and without vulnerability to psychosis in a sample of first-degree relatives, help-seekers and controls were inve...
journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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abstract：:The present study continues the examination of the personality styles in normal populations that have been described in the clinical literature. Earlier work has focused on behavioral, attitudinal, and cognitive components of the personality styles. The present study extends our exploration of the cognitive domain by ...
journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2001-12-15 00:00:00
abstract：:Transdiagnostic approach has a long history in neuroimaging, predating its recent ascendance as a paradigm for new psychiatric nosology. Various psychiatric disorders have been compared for commonalities and differences in neuroanatomical features and activation patterns, with different aims and rationales. This revie...
journal_title：Psychiatry research
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更新日期：2019-07-01 00:00:00
