Abstract：
:Psychosis is associated with low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP), a risk factor for cardiovascular events and mortality in the general population. We investigated the relationship between hs-CRP and anthropometric and metabolic changes in first-episode psychosis (FEP) during the first treatment year. We recruited 95 FEP patients and 62 controls, and measured longitudinal changes in hs-CRP, weight, waist circumference, insulin resistance, and lipids. We used linear mixed models to analyze the longitudinal relationship between hs-CRP and clinical, anthropometric and metabolic measures. At baseline, patients with FEP had higher levels of insulin resistance, total and low-density lipoprotein cholesterol, apolipoprotein B, and triglycerides. Baseline weight, waist circumference, hs-CRP, fasting glucose, and high-density lipoprotein cholesterol were similar between patients and controls. Marked increases in anthropometric measures and hs-CRP were observed in FEP during the 12-month follow-up. However, glucose and lipid parameters did not change significantly. In the mixed models, waist circumference and female sex were significant predictors of hs-CRP levels in FEP. Prevention of the early development of abdominal obesity in FEP is crucial, as abdominal obesity is accompanied by chronic low-grade inflammation, which increases further the cardiovascular risk in this vulnerable population.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Keinänen J,Suvisaari J,Reinikainen J,Kieseppä T,Lindgren M,Mäntylä T,Rikandi E,Sundvall J,Torniainen-Holm M,Mantere Odoi
10.1016/j.psychres.2018.10.022subject
Has Abstractpub_date
2018-12-01 00:00:00pages
547-553eissn
0165-1781issn
1872-7123pii
S0165-1781(18)31065-5journal_volume
270pub_type
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