Abstract：
:Some, but not all studies have reported that a single dose of benzodiazepine affects growth hormone (GH) and cortisol secretion in healthy volunteers. The majority of studies that found GH elevations after benzodiazepine administration did not use placebo trials. The present placebo-controlled investigation determined plasma GH and cortisol levels after intravenous administration of diazepam (0.15 mg/kg) to 10 healthy volunteers. Neither GH nor cortisol secretion changed significantly after diazepam infusion. The lack of placebo trials and the presence of elevated baseline GH values may have been responsible for peak GH elevations reported in previous studies.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Breier A,Charney DS,Heninger GRdoi
10.1016/0165-1781(86)90014-4subject
Has Abstractpub_date
1986-08-01 00:00:00pages
293-9issue
4eissn
0165-1781issn
1872-7123pii
0165-1781(86)90014-4journal_volume
18pub_type
临床试验,杂志文章abstract：:The correlation between scores on the Barratt Impulsiveness Scale (BIS) and activation measured by functional magnetic resonance imaging in a dorsolateral prefrontal cortical (DLPFC) activating task was examined in 15 MDMA-using subjects and 19 controls. A significant correlation between BIS scores and DLPFC activatio...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2006.01.014
更新日期：2006-10-30 00:00:00
abstract：:We examined sex differences in the distribution of psychiatric diagnoses among hospitalized patients, controlling for socio-demographic variables. The sample included 1865 psychiatric inpatients consecutively admitted during a 9-year period. The finding of a higher proportion of men among patients hospitalized for sch...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.11.023
更新日期：2012-06-30 00:00:00
abstract：:Although structural and functional neuroimaging studies of schizophrenia have suggested that impaired connectivity in the extensive network of cortical and subcortical areas is involved in its pathophysiology, there were no studies have investigated the structural integrity of the lower sensory brain areas including t...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2007.12.023
更新日期：2008-11-30 00:00:00
abstract：:A recent genome-wide association study (GWAS) for major depressive disorder (MDD) in Chinese women identified a single-nucleotide polymorphism (SNP), rs12415800, near the Sirtuin1 (SIRT1) gene as one of the top candidate loci. However, no study has shown a genetic association between SIRT1 and completed suicide, which...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.06.002
更新日期：2019-08-01 00:00:00
abstract：:Traditional analyses and interpretation of controlled trials rely on measures of central tendency (e.g., mean findings for treatment versus control) to detect treatment effects. These trial designs therefore emphasize homogeneity of results, with variations within the experimental or control groups treated as error to...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2019.112520
更新日期：2020-01-01 00:00:00
abstract：:Dementia with Lewy bodies (DLB) is a common form of dementia, with fewer memory deficits, and more visuo-perceptual problems than Alzheimer's disease (AD). We hypothesized that there would be disease specific alterations revealed by diffusion tensor imaging with AD showing temporal lobe and DLB more parietal changes. ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2007.01.001
更新日期：2007-07-15 00:00:00
abstract：:Functional magnetic resonance imaging was used to compare cortical activation patterns in healthy volunteers with those in patients with schizophrenia during a modified verbal Stroop task. Healthy subjects (n=13) and patients with schizophrenia (n=13) on stable antipsychotic treatment, matched on demographic variables...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(03)00019-2
更新日期：2003-05-01 00:00:00
abstract：:Needs assessment for patients in mental health care is an important tool. When used systematically, needs assessment can improve the quality of care and facilitate a process of 'shared decision making' in service provision. A self-report questionnaire, the Needs Assessment Scale (NAS), was developed for use in larger ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.02.001
更新日期：2009-05-30 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) research has focused largely on fear processing. However, interpersonal trauma exposure can also impact interpersonal functioning and the perception of the trustworthiness of others. The present study examined facial perceptions of fearfulness and trustworthiness in individuals wit...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.01.056
更新日期：2016-03-30 00:00:00
abstract：:There is evidence for blood inflammatory abnormalities in patients with first-episode psychosis (FEP). The monocyte- and neutrophil-to-lymphocyte ratios (MLR; NLR) are markers of inflammation and endothelial dysfunction, and predictors of cardiovascular disease, the leading cause of death in schizophrenia. We investig...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.11.086
更新日期：2018-02-01 00:00:00
abstract：:General practitioners (GP), on the frontline for individuals with mental health problems, often deal with work-related common psychiatric disorders. We aimed to determine the prevalence of work-related common psychiatric disorders in general practice and associated patients' and GPs' characteristics. HERACLES, a cross...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.09.008
更新日期：2018-01-01 00:00:00
abstract：:There is a considerable literature linking aspects of experienced parenting to later personality disorders. Because dimensionally measured personality disorders are associated with variations in normal personality traits, it is important to understand the contribution of parenting experienced in childhood to later nor...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(02)00128-2
更新日期：2002-08-05 00:00:00
abstract：:This study tested whether sole neurobiological or sociodynamic explanations of alcohol dependence altered respondents' attitudes toward alcohol-dependent patients. We investigated the effect of information leaflets on 444 participants: one group received an information leaflet with a biological explanation of AD; the ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.12.040
更新日期：2014-03-30 00:00:00
abstract：:A key characteristic of bipolar disorder is fluctuation in mood symptoms and functional capacity, yet assessment of bipolar symptomatology often relies heavily on interval measurement that is unable to capture the full range of daily symptom variability and severity. The current study provides a detailed analysis of t...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.04.047
更新日期：2014-08-30 00:00:00
abstract：:One of the central problems in posttraumatic stress disorder (PTSD) is the inability to suppress fear even under safe conditions. The neural underpinnings of fear are clinically relevant but poorly understood. This study assessed fear potentiation and fear inhibition using fear-potentiated startle in a conditional dis...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.12.014
更新日期：2009-05-15 00:00:00
abstract：:Schizophrenia (n=68) and control (n=62) participants matched on cigarette smoking history were assessed on executive function, decision-making and impulsivity tasks. In controls, executive function and decision-making correlated positively with each other and negatively with impulsivity. There were no inter-task corre...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.08.022
更新日期：2013-01-30 00:00:00
abstract：:Toxoplasmosis has been previously associated with an increased risk of having schizophrenia in several epidemiological studies. The aim of this prospective study was to examine for the first time a possible association between positive serology to Toxoplasma gondii (T. gondii) and schizophrenia in the Algerian populat...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113293
更新日期：2020-09-01 00:00:00
abstract：:Heschl's gyrus (HG) is reported to have a normal left>right hemispheric volume asymmetry, and reduced asymmetry in schizophrenia. Primary auditory cortex (A1) occupies the caudal-medial surface of HG, but it is unclear if A1 has normal asymmetry, or whether its asymmetry is altered in schizophrenia. To address these i...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2013.08.009
更新日期：2013-12-30 00:00:00
abstract：:Alzheimer's disease (AD) is clinically characterized by cognitive symptoms that, in combination with behavioral disturbances, significantly interfere with activities of daily living. These behavioral disorders contribute to the clinical heterogeneity of the disease and probably express different pathophysiological pro...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(02)00003-3
更新日期：2002-06-15 00:00:00
abstract：:The Delirium Motor Subtype Scale (DMSS) was developed by discerning the best differentiating motor activity symptoms from the Delirium Motor Checklist (DMC), a compilation of psychomotor symptoms from other subjective scales. To broaden its validation we replicated the original work done in a palliative care populatio...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.08.034
更新日期：2013-03-30 00:00:00
abstract：:Most people with a serious mental illness experience significant functional impairment despite ongoing pharmacological treatment. Thus, in order to improve outcomes, a better understanding of functional predictors is needed. This study examined negative affect, a construct comprised of negative emotional experience, a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.06.031
更新日期：2016-09-30 00:00:00
abstract：:Gilles de la Tourette Syndrome (GTS) and obsessive-compulsive disorder (OCD) share obsessive-compulsive phenomena. The aims of this study were to compare the OC symptom distribution between GTS and OCD and to investigate whether a subdivision of these phenomena into obsessions, compulsions and 'impulsions' is useful i...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(01)00219-0
更新日期：2001-03-25 00:00:00
abstract：:Motivation deficits within Schizophrenia Spectrum Disorders (SSDs) are associated with abnormal striatal dopamine responses during reward processing. Eye blink rate (EBR) has been used as a proxy for striatal dopamine; however, it is unclear whether EBR is sensitive to individual differences in amotivation. Amotivatio...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113490
更新日期：2020-12-01 00:00:00
abstract：:Major depressive disorder (MDD) had been associated with brain-derived neurotrophic factor (BDNF). Studies had shown that patients with MDD were associated with lower BDNF protein levels, which could be reversed by antidepressant treatment. BDNF expression had also been affected by a number of microRNAs (miRNA). BDNF ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.09.025
更新日期：2018-12-01 00:00:00
abstract：:Event schemas, the conceptualization of past experience, in schizophrenic patients were examined based upon script theory. Forty schizophrenic patients and 40 age- and education-matched normal control subjects participated in this study. This experiment consisted of three tasks. In the recall task, subjects recalled a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(99)00051-7
更新日期：1999-10-11 00:00:00
abstract：:Dopamine agonists impair and antagonists normalize prepulse inhibition (PPI) of startle and gating of the P50 event-related potential (ERP), but the within-subject effect of treatment on impaired gating in schizophrenia has not been studied. We report the first results of a longitudinal study using PPI of ERPs as a me...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(98)00053-5
更新日期：1999-02-22 00:00:00
abstract：:Psychiatric symptoms have been reported for individuals who experience chronic exposure to low levels of organic solvents. However, it is not known what proportion of such individuals experience psychiatric disorder; which specific disorders may be characteristic of this population; or whether bioaccumulation of lead ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(00)00217-1
更新日期：2000-12-27 00:00:00
abstract：:The atypical antipsychotic clozapine reduces alcohol drinking in patients with schizophrenia. We have proposed that clozapine׳s ability to decrease alcohol drinking relates to its weak blockade of the dopamine D2 receptor and potent blockade of the norepinephrine α-2 receptor, as well as its ability to elevate plasma ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.04.038
更新日期：2014-08-30 00:00:00
abstract：:The ability to appropriately recognize the facial expression of emotions is essential for the development of adaptive functioning. Studies suggest that maltreated children are hypersensitive to expression of anger. However, the neural mechanism of emotional face processing in young adults with a history of childhood m...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.03.024
更新日期：2019-05-01 00:00:00
abstract：:Although emotional dysfunction is presumed to be a central part of the deficit syndrome in schizophrenia, it has not yet been empirically investigated in deficit and non-deficit patients. Emotional responding was examined in 19 male deficit patients, 22 non-deficit patients, and 20 non-patient controls. Patients parti...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(99)00083-9
更新日期：1999-11-29 00:00:00
