Abstract:
:Dementia with Lewy bodies (DLB) is a common form of dementia, with fewer memory deficits, and more visuo-perceptual problems than Alzheimer's disease (AD). We hypothesized that there would be disease specific alterations revealed by diffusion tensor imaging with AD showing temporal lobe and DLB more parietal changes. We recruited 15 people with AD, 16 with DLB, and 15 healthy control subjects of similar age. They were scanned on a 1.5 T MRI system with diffusion tensor FLAIR imaging. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps were calculated, and data were analysed using pre-defined regions of interest (ROI) and also with SPM. We found a significant decrease in the FA map in a ROI in the parietal lobe (precuneus) of the DLB group. Using SPM we found increased ADC in the left temporal lobe of AD subjects compared to controls. There were no other significant differences between groups. We conclude that there are subtle changes visible with diffusion imaging in DLB and AD which may reflect disrupted connectivity and underlie observed perfusion changes in these disorders.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Firbank MJ,Blamire AM,Krishnan MS,Teodorczuk A,English P,Gholkar A,Harrison RM,O'Brien JTdoi
10.1016/j.pscychresns.2007.01.001subject
Has Abstractpub_date
2007-07-15 00:00:00pages
135-45issue
2eissn
0165-1781issn
1872-7123pii
S0925-4927(07)00016-9journal_volume
155pub_type
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