Abstract：
:Although psychometrically-defined executive function deficits (EFDs) and ecologically valid functional outcomes have been documented among youth with bipolar I (BP-I) disorder, little is known about their association. We hypothesized that EFDs would be associated with significant ecologically valid impairments beyond those predicted by having BP-I disorder. Youth with BP-I disorder were ascertained from psychiatric clinics and community sources. We defined EFDs as having at least two out of eight EF measures impaired from a battery of six tests. Significantly more youth with BP-I disorder had EFDs than controls (45% versus 17%). Comparisons were made between controls without EFDs (N=81), controls with EFDs (N=17), BP-I youth without EFDs (N=76), and BP-I youth with EFDs (N=62). EFDs were associated with an increased risk for placement in a special class and a decrease in academic achievement (WRAT-3 reading and arithmetic). EFDs in BP-I subjects were associated with an increased risk for speech/language disorder (as assessed in the K-SADS-E) relative to BP-I subjects without EFDs. Youth with BP-I disorder and EFDs are at high risk for significant impairments in academic functioning.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Biederman J,Petty CR,Wozniak J,Wilens TE,Fried R,Doyle A,Henin A,Bateman C,Evans M,Faraone SVdoi
10.1016/j.psychres.2010.08.029subject
Has Abstractpub_date
2011-03-30 00:00:00pages
58-64issue
1eissn
0165-1781issn
1872-7123pii
S0165-1781(10)00537-8journal_volume
186pub_type
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