当前位置： SCI文献检索 > PSYCHIATRY RESEARCH期刊下所有文献 > Platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with a first episode of psychosis.

Platelet serotonin and serum cholesterol concentrations in suicidal and non-suicidal male patients with a first episode of psychosis.

Abstract：

:Suicidal behavior is a major health risk in psychiatric disorders, especially in schizophrenia, wherein up to 10% patients will commit suicide. However, the neurobiology of suicide is still unclear. Suicidality has been related to decreased central serotonergic (5-hydroxytryptamine, 5-HT) function and reduced cholesterol levels. Platelet 5-HT has been used as a peripheral marker of the central serotonergic synaptosomes. The aim of this study was to evaluate serum cholesterol and platelet 5-HT concentrations in suicidal and non-suicidal men in the first episode of psychosis and in healthy male controls. Venous blood samples were collected within 24 h of admission, and serum cholesterol and platelet 5-HT were determined enzymatically and fluorimetrically. Platelet 5-HT and serum cholesterol concentrations were significantly lower in suicidal than in non-suicidal patients in the first episode of psychosis, and also lower than in healthy controls. Our results suggest that lower concentrations of serum cholesterol and platelet 5-HT in patients with a first episode of psychosis might be useful biological markers of suicidality.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Marcinko D,Pivac N,Martinac M,Jakovljević M,Mihaljević-Peles A,Muck-Seler D

doi

10.1016/j.psychres.2006.08.012

subject

Has Abstract

pub_date

2007-02-28 00:00:00

pages

105-8

issue

1

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(06)00261-7

journal_volume

150

pub_type

杂志文章

相关文献

PSYCHIATRY RESEARCH文献大全
  • Time perception networks and cognition in schizophrenia: a review and a proposal.

    abstract：:Timing is an essential function for the survival of many living organisms. Despite its significance, it is relatively under-researched, particularly in schizophrenia. We examined neurophysiological, neuropathological, imaging and genetic studies of both healthy subjects and subjects suffering from schizophrenia in rel...

    journal_title：Psychiatry research

    pub_type： 杂志文章,评审

    doi：10.1016/j.psychres.2014.07.048

    authors： Gómez J,Jesús Marín-Méndez J,Molero P,Atakan Z,Ortuño F

    更新日期：2014-12-30 00:00:00

  • Validation of the Investigator's Assessment Questionnaire, a new clinical tool for relative assessment of response to antipsychotics in patients with schizophrenia and schizoaffective disorder.

    abstract：:The success of long-term therapy in schizophrenia is contingent upon real-world effectiveness or improvements in several domains, including efficacy, safety and tolerability. This report describes the Investigator's Assessment Questionnaire (IAQ), a new 10-item instrument designed to assess relative effectiveness (eff...

    journal_title：Psychiatry research

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.psychres.2005.05.006

    authors： Tandon R,Devellis RF,Han J,Li H,Frangou S,Dursun S,Beuzen JN,Carson W,Corey-Lisle PK,Falissard B,Jody DN,Kujawa MJ,L'italien G,Marcus RN,McQuade RD,Ray S,Van Peborgh P,IAQ Validation Study Group.

    更新日期：2005-09-15 00:00:00

  • Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia.

    abstract：:Attentional and executive impairments have been found both in patients with schizophrenia and in their unaffected first-degree relatives, suggesting that they might be considered as familial vulnerability markers. Several studies have shown that the performance of bipolar patients does not significantly differ from th...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/s0165-1781(03)00252-x

    authors： Zalla T,Joyce C,Szöke A,Schürhoff F,Pillon B,Komano O,Perez-Diaz F,Bellivier F,Alter C,Dubois B,Rouillon F,Houde O,Leboyer M

    更新日期：2004-01-01 00:00:00

  • Neural correlates of episodic and semantic memory retrieval in borderline personality disorder: an fMRI study.

    abstract：:Verbal memory impairment in borderline personality disorder (BPD) is still a matter of debate. In this study we combine investigations of both, memory retrieval as well as underlying neural circuits in BPD. Functional magnetic resonance imaging (fMRI) was used to study regional brain activation in 18 right-handed fema...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.pscychresns.2008.02.006

    authors： Mensebach C,Beblo T,Driessen M,Wingenfeld K,Mertens M,Rullkoetter N,Lange W,Markowitsch HJ,Ollech I,Saveedra AS,Rau H,Woermann FG

    更新日期：2009-02-28 00:00:00

  • Depression and social anxiety in help-seeking patients with an ultra-high risk for developing psychosis.

    abstract：:Knowledge on associations between ultra-high risk (UHR) for developing psychosis and on non-psychotic psychopathology in help-seeking populations is limited with respect to differences between male and female patients. The present study tests the hypothesis that both social anxiety and depression are highly prevalent ...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2013.01.012

    authors： Rietdijk J,Ising HK,Dragt S,Klaassen R,Nieman D,Wunderink L,Cuijpers P,Linszen D,van der Gaag M

    更新日期：2013-10-30 00:00:00

  • The effect of discrimination on depression and anxiety symptoms and the buffering role of social capital among female domestic workers in Macao, China.

    abstract：:Foreign migrant domestic workers experience an increased burden of mental disorders. Discrimination contributes to this burden. Social resources may buffer migrants from the effects of this discrimination. The present study explored the relationship between discrimination and common mental disorder (CMD) symptoms, anx...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2018.11.050

    authors： Hall BJ,Pangan CAC,Chan EWW,Huang RL

    更新日期：2019-01-01 00:00:00

  • The role of premorbid personality and social cognition in suicidal behaviour in first-episode psychosis: A one-year follow-up study.

    abstract：BACKGROUND:High suicide attempt (SA) rates have been reported in first-episode psychosis (FEP) patients, particularly during the first year after the illness onset. Despite previous studies establishing several risk factors for suicidal behaviour in FEP, premorbid personality and social cognition have not been sufficie...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2017.05.050

    authors： Canal-Rivero M,Lopez-Moriñigo JD,Barrigón ML,Perona-Garcelán S,Jimenez-Casado C,David AS,Obiols-Llandrich JE,Ruiz-Veguilla M

    更新日期：2017-10-01 00:00:00

  • Low HVA and normal 5HIAA CSF levels in drug-free schizophrenic patients compared to healthy volunteers: correlations to symptomatology and family history.

    abstract：:Cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5HIAA) were determined in 40 drug-free schizophrenic patients and 21 healthy volunteers by a mass fragmentographic method. Twenty-one of the schizophrenic patients were first admissions who had never received neuroleptics. Sign...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/0165-1781(85)90095-2

    authors： Lindström LH

    更新日期：1985-04-01 00:00:00

  • Association between gene variants and response to buprenorphine maintenance treatment.

    abstract：:A variety of studies were addressed to differentiate responders and non-responders to substitution treatment among heroin dependent patients, without conclusive findings. In particular, preliminary pharmacogenetic findings have been reported to predict treatment effectiveness in mental health and substance use disorde...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2013.11.001

    authors： Gerra G,Somaini L,Leonardi C,Cortese E,Maremmani I,Manfredini M,Donnini C

    更新日期：2014-01-30 00:00:00

  • Respiratory panic disorder subtype: acute and long-term response to nortriptyline, a noradrenergic tricyclic antidepressant.

    abstract：:The goal of the study was to describe with prospective methodology the therapeutic response to nortriptyline in the respiratory panic disorder (PD) subtype versus the non-respiratory subtype. A total of 118 PD outpatients (DSM-IV) were previously divided into respiratory (n=77) and non-respiratory (n=41) subtypes and ...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/s0165-1781(03)00132-x

    authors： Nardi AE,Nascimento I,Valença AM,Lopes FL,Mezzasalma MA,Zin WA,Versiani M

    更新日期：2003-10-15 00:00:00

  • Psychiatrists׳ fear of death is associated with negative emotions toward borderline personality disorder patients.

    abstract：:This study examines the relationship between psychiatrists׳ fear of death and negative emotions toward patients with borderline personality disorder (BPD). A survey (N=120) demonstrated that fear of death is associated with stronger negative attitudes toward BPD patients, after controlling for attitudes toward suicide...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2015.06.010

    authors： Bodner E,Shrira A,Hermesh H,Ben-Ezra M,Iancu I

    更新日期：2015-08-30 00:00:00

  • Can sleep disturbance in depression predict repetitive transcranial magnetic stimulation (rTMS) treatment response?

    abstract：:Treatment for depression is not effective in all patients and it is therefore important to identify factors that can be used to tailor treatments. One potential factor is insomnia. Several repetitive transcranial magnetic stimulation (rTMS) studies have reported on this symptom, however, they did not take into account...

    journal_title：Psychiatry research

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.psychres.2013.04.028

    authors： Lowe A,Rajaratnam SM,Hoy K,Taffe J,Fitzgerald PB

    更新日期：2013-11-30 00:00:00

  • Is a gin and tonic more like gin or tonic? A comparison of comorbid and non-comorbid anxiety disorder diagnostic pairs.

    abstract：:Despite findings indicating that anxiety disorders are more likely to co-occur with each other than occur in isolation, little research has explored precise areas of overlap and differentiation among comorbid pairs of anxiety disorders. Furthermore, many studies comparing phenomena across anxiety disorders define comp...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2014.11.017

    authors： Norton PJ,Chase TE

    更新日期：2015-01-30 00:00:00

  • Serotonin uptake by blood platelets of schizophrenic patients.

    abstract：:Active uptake of serotonin (5-hydroxytryptamine, 5-HT) by blood platelets of acute and chronic schizophrenic patients was compared with that of normal controls. Unlike previous reports, no significant difference in the kinetic parameters (Km and Vmax) of 5-HT uptake between schizophrenic patients and normal controls w...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/0165-1781(82)90022-1

    authors： Arora RC,Meltzer HY

    更新日期：1982-06-01 00:00:00

  • Exploring parental mentalization in postnatal phase with a self-report questionnaire (PRFQ): Factor structure, gender differences and association with sociodemographic factors. The Finn Brain Birth Cohort Study.

    abstract：:The objective was to explore the preliminary functioning of a self-report questionnaire designed to assess parental reflective functioning (PRFQ, Luyten et al., 2009, unpublished manual) during early postnatal phase and with a large population-based sample. Parental reflective functioning (PRF) refers to parental capa...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2017.09.020

    authors： Pajulo M,Tolvanen M,Pyykkönen N,Karlsson L,Mayes L,Karlsson H

    更新日期：2018-04-01 00:00:00

  • Night light alters menstrual cycles.

    abstract：:Dewan asserted 20 years ago that a bedside light could shorten and regularize the menstrual cycle among women with long and irregular menstrual patterns. To replicate this, seven volunteers slept with a 100-watt bulb by the bedside from days 13-17 of their menstrual cycles, while nine controls similarly used a dim red...

    journal_title：Psychiatry research

    pub_type： 临床试验,杂志文章

    doi：10.1016/0165-1781(90)90067-f

    authors： Lin MC,Kripke DF,Parry BL,Berga SL

    更新日期：1990-08-01 00:00:00

  • Assertive outreach for "difficult to engage" patients: A useful tool for a subgroup of patients in specialized early psychosis intervention programs.

    abstract：PURPOSE:Most specialized Early Psychosis (EP) programs include assertive outreach (AO) principles, either for all patients or as an intensive case management (ICM) subprogram in selected situations. The objective of this study is to examine prevalence, characteristics and outcomes of patients who needed additional ICM ...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2016.03.010

    authors： Alameda L,Golay P,Baumann P,Morandi S,Ferrari C,Conus P,Bonsack C

    更新日期：2016-05-30 00:00:00

  • Anxiety sensitivity and mindful attention in terms of anxiety and depressive symptoms and disorders among Latinos in primary care.

    abstract：:The present investigation examined the interactive effects of anxiety sensitivity and mindful attention in relation to anxiety and depressive symptoms and psychopathology among 145 adult Latinos (85.5% female; Mage=39.9, SD=10.8 and 98.6% used Spanish as their first language) who attended a community-based primary hea...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2015.07.026

    authors： Zvolensky MJ,Bakhshaie J,Garza M,Paulus DJ,Valdivieso J,Lam H,Bogiaizian D,Robles Z,Schmidt NB,Vujanovic A

    更新日期：2015-09-30 00:00:00

  • An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder.

    abstract：:The pathophysiology of pediatric bipolar disorder (PBD) impacts both affective and cognitive brain systems. Understanding disturbances in the neural circuits subserving these abilities is critical for characterizing developmental aberrations associated with the disorder and developing improved treatments. Our objectiv...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.pscychresns.2007.10.003

    authors： Pavuluri MN,O'Connor MM,Harral EM,Sweeney JA

    更新日期：2008-04-15 00:00:00

  • Low brain serotonin transporter binding in major depressive disorder.

    abstract：:We examined midbrain, medial temporal lobe, and basal ganglia serotonin transporter (SERT) distribution volume ratio (DVR) values in subjects with major depressive disorder versus healthy volunteers using a selective SERT radioligand and single photon emission computed tomography (SPECT). We hypothesized that the DVR ...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.pscychresns.2011.12.015

    authors： Newberg AB,Amsterdam JD,Wintering N,Shults J

    更新日期：2012-05-31 00:00:00

  • The association of MHPG to dexamethasone suppression test status.

    abstract：:The results of the dexamethasone suppression test (DST) were compared to levels of 24-hour 3-methoxy-4-hydroxyphenylglycol (MHPG) in 60 patients with unipolar depression. DST nonsuppressors had significantly higher levels of MHPG than did DST suppressors. The possible implications of this finding are discussed. ...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/0165-1781(88)90065-0

    authors： Garvey MJ,Hollon S,Evans M,DeRubeis RJ,Tuason VB

    更新日期：1988-05-01 00:00:00

  • Pregnancy, delivery and postpartum in women with schizophrenia or schizoaffective disorder in Finland: a national register-based comparative study.

    abstract：:As part of anational Finnish study on reproductive health of women with severe mental disorders, we compared pregnancy- and delivery-, and postpartum-related outcomes between women with schizophrenia (n = 3444) and those with schizoaffective disorder (n = 985), focusing on their singleton pregnancies after illness ons...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2020.113504

    authors： Simoila L,Isometsä E,Gissler M,Suvisaari J,Sailas E,Halmesmäki E,Lindberg N

    更新日期：2020-12-01 00:00:00

  • Evidence for perturbed metabolic patterns in bipolar disorder subjects associated with lithium responsiveness.

    abstract：:Bipolar disorder (BD) is multifactorial mood disorder characterized by alternating episodes of hyperactive mania and severe depression. Lithium is one of the most preferred drug used as mood stabilizer in treating BD. In this study, we examined the changes in plasma metabolome in BD subjects in the context of lithium ...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2019.01.031

    authors： Joshi MB,Pai S,Balakrishnan A,Bhat M,Kotambail A,Sharma P,Satyamoorthy K

    更新日期：2019-03-01 00:00:00

  • Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging study.

    abstract：:The subgenual prefrontal cortex (SGPFC) plays an important role in emotional processing. We carried out a magnetic resonance imaging (MRI) study comparing the volume of the SGPFC in child and adolescent bipolar patients and healthy controls. The sample consisted of 15 children and adolescents who met DSM-IV criteria f...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.pscychresns.2004.11.004

    authors： Sanches M,Sassi RB,Axelson D,Nicoletti M,Brambilla P,Hatch JP,Keshavan MS,Ryan ND,Birmaher B,Soares JC

    更新日期：2005-01-30 00:00:00

  • Disordered eating behaviors in adolescents and adults living in the same household in metropolitan area of Rio de Janeiro, Brazil.

    abstract：OBJECTIVE:To examine the prevalence of disordered eating behaviors among adolescents and adults living in the same household. METHODS:We conducted a population-based cross-sectional study developed with a probabilistic sample of 511 adolescents and 1254 adults living in the metropolitan area of Rio de Janeiro, Brazil....

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2013.06.021

    authors： Ferreira JE,de Souza PR Jr,da Costa RS,Sichieri R,da Veiga GV

    更新日期：2013-12-15 00:00:00

  • Platelet serotonin uptake: methods and strain differences.

    abstract：:The pharmacokinetic properties of platelets make these vascular elements a potential and convenient model for serotoninergic neurons. Because we encountered several difficulties in preliminary platelet serotonin (5HT) uptake assays, we explored the influence of several assay factors on the parameters obtained. We foun...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/0165-1781(87)90051-5

    authors： Codd EE,Walker RF

    更新日期：1987-09-01 00:00:00

  • Explicit self-esteem mediates the relationship between implicit self-esteem and memory biases in major depression.

    abstract：:This study examines the relationships between explicit and implicit self-esteem and self-referent memory biases in depression. We specifically tested the hypothesis that implicit self-esteem would influence depression-related memory biases via its association with explicit self-esteem. Self-esteem was assessed in pati...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2016.06.003

    authors： Romero N,Sanchez A,Vázquez C,Valiente C

    更新日期：2016-08-30 00:00:00

  • Psychobiological response to an anger induction task in schizophrenia: The key role of anxiety.

    abstract：:In this study an anger induction laboratory task was applied to men with schizophrenia, and resulted in significant changes in different psychophysiological parameters that were measured in a pre-post design. We observed a significantly greater self-reported anger mood and negative affection, lower self-reported posit...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2018.12.044

    authors： Gadea M,Herrero N,Picó A,Espert R,Salvador A,Sanjuán J

    更新日期：2019-01-01 00:00:00

  • Development and validation of Attitudes towards Recovery Questionnaire across Chinese people in recovery, their family carers, and service providers in Hong Kong.

    abstract：:Considering the lack of existing measures on attitudes toward personal recovery and the need to acknowledge the cultural milieu in recovery attitude assessment, the present study developed and validated the Attitudes towards Recovery Questionnaire (ARQ) in a sample of people in recovery of mental illness, family carer...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2018.05.047

    authors： Mak WWS,Chan RCH,Yau SSW

    更新日期：2018-09-01 00:00:00

  • Neurological soft signs in Chinese adolescents with antisocial personality traits.

    abstract：:The current study was designed to explore the specific relationship between neurologic soft signs (NSSs) and characteristics of antisocial personality traits in adolescents, and to investigate particular NSSs linked to certain brain regions in adolescents with antisocial personality traits. The research was conducted ...

    journal_title：Psychiatry research

    pub_type： 杂志文章

    doi：10.1016/j.psychres.2016.04.023

    authors： Wang X,Cai L,Li L,Yang Y,Yao S,Zhu X

    更新日期：2016-09-30 00:00:00