Abstract:
:Active uptake of serotonin (5-hydroxytryptamine, 5-HT) by blood platelets of acute and chronic schizophrenic patients was compared with that of normal controls. Unlike previous reports, no significant difference in the kinetic parameters (Km and Vmax) of 5-HT uptake between schizophrenic patients and normal controls was observed, although a trend toward decreased Vmax in the acute schizophrenics was present. Since decreased Vmax of platelet 5-HT uptake has been found in patients with bipolar, unipolar, and schizoaffective depression, further study of the usefulness of platelet 5-HT uptake as a biological marker for major depressive illness is indicated. Abnormalities of 5-HT uptake do not appear to contribute significantly to the increased platelet 5-HT levels which have been reported in schizophrenic patients.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Arora RC,Meltzer HYdoi
10.1016/0165-1781(82)90022-1subject
Has Abstractpub_date
1982-06-01 00:00:00pages
327-33issue
3eissn
0165-1781issn
1872-7123pii
0165-1781(82)90022-1journal_volume
6pub_type
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journal_title:Psychiatry research
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journal_title:Psychiatry research
pub_type: 杂志文章
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journal_title:Psychiatry research
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journal_title:Psychiatry research
pub_type: 杂志文章
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journal_title:Psychiatry research
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00