Serotonin uptake by blood platelets of schizophrenic patients.

Abstract:

:Active uptake of serotonin (5-hydroxytryptamine, 5-HT) by blood platelets of acute and chronic schizophrenic patients was compared with that of normal controls. Unlike previous reports, no significant difference in the kinetic parameters (Km and Vmax) of 5-HT uptake between schizophrenic patients and normal controls was observed, although a trend toward decreased Vmax in the acute schizophrenics was present. Since decreased Vmax of platelet 5-HT uptake has been found in patients with bipolar, unipolar, and schizoaffective depression, further study of the usefulness of platelet 5-HT uptake as a biological marker for major depressive illness is indicated. Abnormalities of 5-HT uptake do not appear to contribute significantly to the increased platelet 5-HT levels which have been reported in schizophrenic patients.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Arora RC,Meltzer HY

doi

10.1016/0165-1781(82)90022-1

subject

Has Abstract

pub_date

1982-06-01 00:00:00

pages

327-33

issue

3

eissn

0165-1781

issn

1872-7123

pii

0165-1781(82)90022-1

journal_volume

6

pub_type

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