Abstract:
:Several lines of evidence suggest that lactate metabolism may be altered in panic disorder. We recently reported exaggerated increases in serum lactate in panic patients following hyperventilation during glucose infusion. In the current study, lactate metabolism was stimulated by hyperventilation following glucose ingestion in 12 panic patients and 12 controls. The seven patients who panicked during hyperventilation exhibited larger increases in serum lactate levels than nonpanicking patients or controls. The lactate response was significantly correlated with peak ratings of anxiety and panic symptoms, but not correlated with insulin or cortisol levels, heart rate, pCO2, adiposity, exercise habits, or diet. Hyperventilation-induced panic appears to be associated with metabolic changes leading to elevated serum lactate.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Maddock RJ,Carter CS,Gietzen DWdoi
10.1016/0165-1781(91)90020-psubject
Has Abstractpub_date
1991-09-01 00:00:00pages
301-11issue
3eissn
0165-1781issn
1872-7123pii
0165-1781(91)90020-Pjournal_volume
38pub_type
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