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Cortical thickness differences in the prefrontal cortex in children and adolescents with ADHD in relation to dopamine transporter (DAT1) genotype.

Abstract：

:Several lines of evidence suggest that the dopamine transporter gene (DAT1) plays a crucial role in attention deficit hyperactivity disorder (ADHD). Concretely, recent data indicate that the 10-repeat (10R) DAT1 allele may mediate neuropsychological functioning, response to methylphenidate, and even brain function and structure in children with ADHD. This study aimed to investigate the influence of 10R DAT1 on thickness of the prefrontal cortex in children and adolescents with ADHD. To this end, brain magnetic resonance images were acquired from 33 patients with homozygosity for the 10R allele and 30 patients with a single copy or no copy of the allele. The prefrontal cortex of each MRI scan was automatically parceled into regions of interest (ROIs) based on Brodmann areas (BA). The two groups were matched for age, gender, IQ, ADHD subtype, symptom severity, comorbidity and medication status. However, patients with two copies of the 10R allele exhibited significantly decreased cortical thickness in right BA 46 relative to patients with one or fewer copies of the allele. No other prefrontal ROI differed significantly between the two groups. Present findings suggest that cortical thickness of right lateral prefrontal cortex (BA 46) is influenced by the presence of the DAT1 10 repeat allele in children and adolescents with ADHD.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Fernández-Jaén A,López-Martín S,Albert J,Fernández-Mayoralas DM,Fernández-Perrone AL,de La Peña MJ,Calleja-Pérez B,Rodríguez MR,López-Arribas S,Muñoz-Jareño N

doi

10.1016/j.pscychresns.2015.07.005

subject

Has Abstract

pub_date

2015-09-30 00:00:00

pages

409-17

issue

3

eissn

0165-1781

issn

1872-7123

pii

S0925-4927(15)30029-9

journal_volume

233

pub_type

杂志文章

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