Abstract：
:Few investigations have assessed the neuropsychological effects of psychotropic medications on schizophrenic patients. In this study, 44 clinically stable schizophrenic inpatients were administered a battery of neuropsychological tests, and their performance was correlated with dosage of neuroleptic medication and benztropine. Neuroleptic dose was correlated with poorer performance on tests of psychomotor speed and attention, and with the number of perserverative errors on the Wisconsin Card Sort. Anticholinergic dose was associated with poorer verbal learning, verbal fluency, and motor speed. Both medication dosages were associated with poorer verbal recognition memory, but this association was strongly influenced by the performance of individuals on the highest medication doses. The findings, which were independent of clinical state and intelligence, indicate that higher doses of neuroleptic and anticholinergic medications are associated with poorer neuropsychological functioning in schizophrenia.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Sweeney JA,Keilp JG,Haas GL,Hill J,Weiden PJdoi
10.1016/0165-1781(91)90065-wsubject
Has Abstractpub_date
1991-06-01 00:00:00pages
297-308issue
3eissn
0165-1781issn
1872-7123pii
0165-1781(91)90065-Wjournal_volume
37pub_type
杂志文章abstract：:This study aimed to determine whether (1) cognitive behavioural therapy with behavioural analysis for insomnia (CBTi-BA) is more effective for insomnia and co-morbid depressive symptoms than treatment as usual (TAU) and (2) whether CBTi-BA promotes earlier reduction of the daily dose of hypnotic medication in chronic ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.06.028
更新日期：2013-12-15 00:00:00
abstract：:The aim of this study was to investigate the blood lead level and parental marital status that might influence the development of attention-deficit/hyperactivity disorder (ADHD) symptoms in school-aged children. The participants in the survey included elementary school children, and they were followed up biennially. T...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.01.002
更新日期：2016-02-28 00:00:00
abstract：:Positron emission tomography with [18F]-fluoro-2-deoxy-D-glucose as tracer was used to investigate frontal glucose metabolism in 15 unmedicated schizophrenic patients and 15 healthy subjects under resting conditions. Although no difference in absolute frontal cerebral metabolic rates of glucose (CMRglu) were found bet...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(95)02672-k
更新日期：1995-09-29 00:00:00
abstract：:This school-based study aimed to investigate the prevalence of being at risk for depression, bullying behavior, and current smoking among Chinese adolescents in order to explore gender differences in the vulnerability of adolescents with these behaviors to develop a smoking habit. A total of 35,893 high school student...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.01.027
更新日期：2016-03-30 00:00:00
abstract：:Recent magnetic resonance imaging (MRI) studies using diffusion tensor imaging (DTI) have suggested reduced fractional anisotropy (FA) in the white matter (WM) of the brain in patients with schizophrenia. We tried to examine whether such reduction in FA exists and whether such changes in FA progress in an age-dependen...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2006.09.004
更新日期：2007-02-28 00:00:00
abstract：:Considering the lack of existing measures on attitudes toward personal recovery and the need to acknowledge the cultural milieu in recovery attitude assessment, the present study developed and validated the Attitudes towards Recovery Questionnaire (ARQ) in a sample of people in recovery of mental illness, family carer...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.05.047
更新日期：2018-09-01 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) is frequently associated with major depressive disorder, and antidepressants have been reported to ameliorate PTSD symptoms in some patients. The present study assessed the number and affinity of platelet imipramine binding sites, as a marker of the serotonin transporter complex, i...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(96)02760-6
更新日期：1996-07-31 00:00:00
abstract：:We investigated a 27-year old patient with paranoid schizophrenia. Brain activity related to visual hallucinations was found in higher visual areas corresponding to the content of the hallucinations (faces, bodies, scenes) and the hippocampus. We assume that the hippocampal activity is related to the retrieval of visu...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2007.09.004
更新日期：2007-12-15 00:00:00
abstract：:To date, there are no data on quality of life (QOL) and its correlates in homeless Chinese patients with psychiatric disorders. This study aimed to compare QOL between homeless and non-homeless patients with psychiatric disorders in China. A total of 278 homeless and 222 non-homeless patients matched in age and gender...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.01.016
更新日期：2017-03-01 00:00:00
abstract：:The aim of this study was to develop self-report and clinician-rated versions of an insight scale that would be easy to administer, sensitive to small changes, and inclusive of the core dimensions of clinical insight into psychosis. Ten-item self-report (VAGUS-SR) and five-item clinician-rated (VAGUS-CR) scales were d...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.08.005
更新日期：2014-12-30 00:00:00
abstract：:Alcohol misuse is associated with negative mental and physical health outcomes, which presents a public health concern in veterans. However, less is known regarding outcomes among veterans with low to moderate alcohol consumption. This study included veterans with military service in Iraq and/or Afghanistan (N = 1083)...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.09.067
更新日期：2018-01-01 00:00:00
abstract：:The Edinburgh High Risk Project is a longitudinal study of brain structure (and function) in subjects at high risk of developing schizophrenia in the next 5-10 years for genetic reasons. In this article we describe the methods of volumetric analysis of structural magnetic resonance images used in the study. We also co...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(99)00012-8
更新日期：1999-07-30 00:00:00
abstract：:This paper reports on a new family-centred, feedback-informed intervention focused on evaluating therapeutic outcomes and language changes across treatment for conduct disorder (CD). The study included 26 youth and families from a larger randomised, controlled trial (Ronan et al., in preparation). Outcome measures ref...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2016.11.035
更新日期：2017-05-01 00:00:00
abstract：:Medication non adherence in schizophrenia is a major cause of relapse and hospitalization and remains for clinicians an important challenge. This study investigates the associations between insight, therapeutic alliance, perceived trauma related to psychiatric treatment and medication adherence in patients with schizo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.07.063
更新日期：2017-11-01 00:00:00
abstract：:The aim of this study was to examine insomnia symptoms, behavioral problems, and suicidality among adolescents of insomniac parents (IP) and non-insomniac parents (NIP). A family survey of sleep and health was conducted among 1090 adolescents and their parents in Jinan, China. Adolescents completed a sleep and health ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.05.023
更新日期：2015-08-30 00:00:00
abstract：:The objective of the study was to scrutinize in detail the changes that occur in left ventricle (LV) systolic and diastolic functions using echocardiography in patients with at least 5 years of history and 40 healthy volunteers matching the patients in age and gender, who were enrolled in a cross-sectional study. All ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.04.025
更新日期：2016-06-30 00:00:00
abstract：:Schizophrenia is a highly heritable psychiatric disorder often associated with dopamine-related genetic variations. Thus, we performed a case-control study in 1504 Han Chinese population to evaluate the association of DRD1, DRD2 and DRD3 polymorphisms with schizophrenia. No statistically significant difference in alle...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.08.052
更新日期：2016-11-30 00:00:00
abstract：:Repetitive transcranial magnetic stimulation (rTMS) is currently undergoing active investigation for use in the treatment of major depression. Recent research has indicated that current methods used to localize the site of stimulation in dorsolateral prefrontal cortex (DLPFC) are significantly inaccurate. However, lit...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.pscychresns.2006.04.006
更新日期：2006-11-22 00:00:00
abstract：:Childhood trauma exposure has been associated with a clinically relevant mixed phenotype of psychopathology composed of depressive, anxiety, and psychosis symptoms, across healthy and clinical samples. Altered stress-reactivity after exposure to childhood trauma may be a plausible underlying mechanism explaining this ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.12.012
更新日期：2018-02-01 00:00:00
abstract：:In order to measure the intrafamilial correlation for age at onset and to examine gender resemblance among bipolar siblings, we assessed a sample of 130 bipolar patients belonging to 59 multiple affected sibships. To study the intrafamilial resemblance for age at onset and gender, we used the intraclass correlation an...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(98)00087-0
更新日期：1998-11-16 00:00:00
abstract：:Several lines of evidence suggest that the dopamine transporter gene (DAT1) plays a crucial role in attention deficit hyperactivity disorder (ADHD). Concretely, recent data indicate that the 10-repeat (10R) DAT1 allele may mediate neuropsychological functioning, response to methylphenidate, and even brain function and...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2015.07.005
更新日期：2015-09-30 00:00:00
abstract：:Two studies have shown that increasing the consultation of the word "suicide" in the Google search engine was associated with a subsequent increase in the prevalence of suicide attempts. The main goal of this article was to explore the trends generated by a key-word search associated with suicide, depression and bipol...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.04.022
更新日期：2015-08-30 00:00:00
abstract：:The aim of the present study was the validation of the Acquired Capability for Suicide Scale-Fearlessness about Death (ACSS-FAD) in a large population sample to further establish its reliability and validity, and to provide norm values. We assessed the ACSS-FAD, measures of depression, history of suicidal behavior, an...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.01.052
更新日期：2016-04-30 00:00:00
abstract：:Patients with depression exhibit high rates of alexithymia, representing a major public health concern. We sought to examine relationships between depression severity and alexithymia as assessed by the Toronto Alexithymia Scale (TAS-20) and the TAS-20 subscales of difficulty identifying feelings (DIF), difficulty desc...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.psychres.2015.02.006
更新日期：2015-05-30 00:00:00
abstract：:Event-related potentials in two auditory target detection paradigms and two auditory paradigms without overt tasks were studied in 22 schizophrenic, 21 depressed, and 28 matched control subjects meeting Research Diagnostic Criteria. In the target detection paradigms, schizophrenics showed a pattern of reduced N120 amp...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(81)90023-8
更新日期：1981-04-01 00:00:00
abstract：:Growing evidence supports a continuum model of psychosis, with mild psychotic symptoms being frequently experienced by the general population. Moreover, believing in the continuum model correlates with less stigmatization of schizophrenia. This study explores whether continuum beliefs are a valid construct and develop...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.04.085
更新日期：2016-07-30 00:00:00
abstract：:Previous work suggests that iomazenil (formerly known as Ro 16-0154) is a useful ligand for static imaging of the benzodiazepine (BZ) receptor with single photon emission computed tomography (SPECT). The present study evaluated the feasibility of dynamic SPECT imaging of cerebral radioactivity following intravenous [1...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(92)90001-k
更新日期：1992-08-01 00:00:00
abstract：:N-Acetyl-aspartate (NAA), a marker of neuronal integrity, has been found to be reduced in frontal regions in schizophrenia. However, the impact of antipsychotic drug type on NAA has not been carefully evaluated. We studied outpatients with schizophrenia/schizoaffective disorders chronically treated with haloperidol or...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(01)00102-0
更新日期：2001-10-01 00:00:00
abstract：:The study identifies the correlation between the quality of life (QoL) among outpatients with schizophrenia and clinical outcomes. A cross-sectional study design was used with 157 people with schizophrenia treated in outpatient clinics. Demographic, clinical and psychosocial variables were examined for their influence...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.09.062
更新日期：2019-01-01 00:00:00
abstract：:Suicide rates vary among racel- and age-defined groups, yet little is known about how suicide risk factors differentially impact individual groups. This study assessed differential associations of socioeconomic status among age- and race-defined groups of suicide victims. A database containing demographic information ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.02.003
更新日期：2009-05-30 00:00:00
