Abstract：
:Two groups of 30 patients with obsessive-compulsive disorder and 30 age- and sex-matched healthy control subjects were given a growth hormone-releasing hormone (GHRH) stimulation test to determine: (1) whether the downstream function of the somatotropic axis (growth hormone = GH, somatomedin-C = SMD-C) was impaired; (2) what might be the central alteration responsible for such impairment; and (3) whether alterations might be linked to the etiopathogenesis of the disease. Basal values of GH and SMD-C were the same in patients and control subjects, but GH responses to GHRH stimulation were significantly lower in patients than in control subjects. The absence of a pathology of basal GH and SMD-C concentrations indicates that the blunted GH responses to GHRH stimulation are not due to a negative feedback mechanism and suggests that a central neurotransmitter-neuropeptide pathology might be involved in the phenomenon.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Brambilla F,Bellodi L,Perna G,Arancio C,Bertani Adoi
10.1016/s0165-1781(98)00124-3subject
Has Abstractpub_date
1998-12-14 00:00:00pages
293-9issue
3eissn
0165-1781issn
1872-7123pii
S0165178198001243journal_volume
81pub_type
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