Abstract：
:While cannabis is associated with positive syndrome schizophrenia (SZ), it is unclear whether cannabinoids are also related to negative symptoms such as affective blunting. We examined whether cannabis use is associated with schizotypy and utilized event-related potentials (ERPs) to assess affect processing. Cannabis users demonstrated increased P300 amplitudes for unpleasant trait words, and demonstrated higher positive syndrome schizotypy which correlated with levels of cannabis use. The cannabis group also exhibited lower negative syndrome schizotypy. The lack of blunted responses during the affect ERP and decreased negative subscale schizotypy scores provide evidence that the endocannabinoid theory of schizophrenia may be primarily relevant in relation to positive syndrome SZ.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Skosnik PD,Park S,Dobbs L,Gardner WLdoi
10.1016/j.psychres.2007.02.010subject
Has Abstractpub_date
2008-01-15 00:00:00pages
279-82issue
1-3eissn
0165-1781issn
1872-7123pii
S0165-1781(07)00040-6journal_volume
157pub_type
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