Abstract：
:The primary goal of this study was to examine the biochemical abnormalities of late-life major depression by using 3-tesla (3-T) proton magnetic resonance spectroscopy ((1)H-MRS). The antidepressant effects on the biochemical abnormalities were investigated as well. Study participants were 27 elderly patients with major depressive disorders (among which 9 were on antidepressant medication) and 19 comparison elderly subjects. (1)H-MRS spectra were acquired from voxels that were placed in the left frontal white matter, left periventricular white matter, and left basal ganglia. Ratios of N-acetylaspartate (NAA), choline (Cho) and myo-inositol to creatine were calculated. Patients with late-life major depressive disorder had a significantly lower NAA/creatine ratio in the left frontal white matter, and higher Cho/creatine and myo-inositol/creatine ratios in the left basal ganglia when compared with the control subjects. The myo-inositol correlated with global cognitive function among the patients. The biochemical abnormalities in late-life major depressive disorder were found on the left side of the frontal white matter and the basal ganglia. Neuron degeneration in the frontal white matter and second messenger system dysfunction or glial dysfunction in the basal ganglia are suggested to be associated with late-life depression.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Chen CS,Chiang IC,Li CW,Lin WC,Lu CY,Hsieh TJ,Liu GC,Lin HF,Kuo YTdoi
10.1016/j.pscychresns.2009.01.003subject
Has Abstractpub_date
2009-06-30 00:00:00pages
210-4issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(09)00006-7journal_volume
172pub_type
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