Abstract：
:This study tests the hypothesis that adolescents with major depression exhibit abnormalities in cerebral asymmetry previously found among adults. Perceptual asymmetry was assessed through tests of verbal and non-verbal dichotic listening in four groups - 48 adolescents with major depression, 22 adolescent comparisons with no history of Axis I disorders, 149 adults with major depression, and 57 comparison adults with no history of Axis I disorders. Data from adults have been previously reported. In both age groups, subjects with major depression were further divided based on the presence or absence of an anxiety disorder. Procedures used to collect perceptual asymmetry data in adolescents and adults were identical. In both age groups, depressed and healthy subjects showed perceptual asymmetry in expected directions for verbal and non-verbal dichotic tasks. Depressed and comparison subjects differed in performance on the Fused-Word Test, though these differences varied as a function of anxiety and developmental level. Relative to comparisons, both adolescents and adults with major depression exhibited an increased right ear/left hemisphere advantage for fused words. Adults but not adolescents with comorbid major depressive and anxiety disorders exhibited a reduced right ear/left hemisphere advantage for fused words. These findings suggest similarities and differences across development in the relationship between cerebral laterality and psychopathology. Further studies using longitudinal and family-based designs, as well as various measures of regional brain activity, are needed to enhance understanding of associations between cerebral laterality and psychopathology across development.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Pine DS,Kentgen LM,Bruder GE,Leite P,Bearman K,Ma Y,Klein RGdoi
10.1016/s0165-1781(00)00101-3subject
Has Abstractpub_date
2000-03-06 00:00:00pages
135-44issue
2eissn
0165-1781issn
1872-7123pii
S0165-1781(00)00101-3journal_volume
93pub_type
杂志文章abstract：:Thirty-five schizophrenic patients in the early stages of illness, 26 of their healthy siblings, and 35 normal control subjects performed the Continuous Performance Test, Identical Pairs version (CPT-IP). Both schizophrenic patients and their siblings were significantly impaired in their attentional performance compar...
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abstract：:Attention-deficit hyperactivity disorder is a common finding in school children. Because it was suggested to be related to frontal lobe dysfunction, we hypothesized that brain activation would be altered during an event-related color-word matching Stroop task in comparison to a healthy control group. Twelve medication...
journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章,评审
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
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journal_title：Psychiatry research
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更新日期：2012-07-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,meta分析,评审
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更新日期：2012-03-31 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：1992-03-01 00:00:00
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journal_title：Psychiatry research
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更新日期：2015-08-30 00:00:00
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journal_title：Psychiatry research
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更新日期：2013-12-30 00:00:00
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pub_type： 杂志文章,随机对照试验
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更新日期：2015-12-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
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更新日期：2018-12-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2008-10-30 00:00:00
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更新日期：2011-01-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2011-06-30 00:00:00
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pub_type： 杂志文章
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更新日期：1988-07-01 00:00:00
abstract：:A clear measure of eye movement disorder (EMD) that reliably separated schizophrenic individuals from others would both give insight into the brain control of the disorder and provide an aid in diagnosis. In the present study, a detailed analysis was carried out of the interactions between the pursuit and saccadic com...
journal_title：Psychiatry research
pub_type： 杂志文章
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