Desipramine subsensitizes nicotinic mechanism involved in regulating core temperature.

Abstract:

:Desipramine HCl, 10 mg/kg i.p. twice daily, produced subsensitivity to the hypothermic effects of nicotine, 1 mg/kg, after 1 and 2 weeks of treatment in male Sprague-Dawley rats, Phenelzine sulfate, fluoxetine HCl, and bright artificial light produced the same effect. The capacity of three chemically distinct classes of anti-depressants and bright artificial light (a treatment for seasonal depression) to produce this result suggests that effects on nicotinic mechanisms may be involved in the mechanism of action of these treatments.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Dilsauer SC,Hariharen M,Davidson RK

doi

10.1016/0165-1781(88)90164-3

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

105-8

issue

1

eissn

0165-1781

issn

1872-7123

pii

0165-1781(88)90164-3

journal_volume

25

pub_type

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