Abstract：
:Motivation deficits within Schizophrenia Spectrum Disorders (SSDs) are associated with abnormal striatal dopamine responses during reward processing. Eye blink rate (EBR) has been used as a proxy for striatal dopamine; however, it is unclear whether EBR is sensitive to individual differences in amotivation. Amotivation (clinician-rated and self-reported) and EBR during an effort-based reward task were assessed in 28 outpatients with SSDs. EBR was lower during more "active" task phases relative to rest periods. Higher EBR during reward anticipation was associated with lower self-reported, but not clinician-rated, motivation. These preliminary results support a task-engagement, rather than striatal dopamine, account of EBR.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
McGovern JE,Masucci MD,Le TP,Cohen ASdoi
10.1016/j.psychres.2020.113490subject
Has Abstractpub_date
2020-12-01 00:00:00pages
113490eissn
0165-1781issn
1872-7123pii
S0165-1781(20)33151-6journal_volume
294pub_type
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