Abstract：
:Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα and mRNA levels from patients with schizophrenia, with additional BMI interactions, characterizing dysregulation of genes relating to metabolic-inflammation in schizophrenia.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Chase KA,Rosen C,Gin H,Bjorkquist O,Feiner B,Marvin R,Conrin S,Sharma RPdoi
10.1016/j.psychres.2014.11.007subject
Has Abstractpub_date
2015-01-30 00:00:00pages
208-211issue
1-2eissn
0165-1781issn
1872-7123pii
S0165-1781(14)00859-2journal_volume
225pub_type
杂志文章abstract：:The success of long-term therapy in schizophrenia is contingent upon real-world effectiveness or improvements in several domains, including efficacy, safety and tolerability. This report describes the Investigator's Assessment Questionnaire (IAQ), a new 10-item instrument designed to assess relative effectiveness (eff...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.psychres.2005.05.006
更新日期：2005-09-15 00:00:00
abstract：:Research suggests that those with antisocial tendencies are larger than controls, but studies have not assessed this association in antisocial personality disorder (APD) or its hypothesized sub-types (i.e. adolescence-limited, late-onset). Height, weight, body mass index, bulk, and psychosocial adversity were assessed...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(01)00344-4
更新日期：2001-12-31 00:00:00
abstract：:We developed a physical exercise intervention aimed at improving multiple determinants of physical performance in severe mental illness. A sample of 12 (9M, 3F) overweight or obese community-dwelling patients with schizophrenia (n=9) and bipolar disorder (n=3) completed an eight-week, high-velocity circuit resistance ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.07.007
更新日期：2015-09-30 00:00:00
abstract：:This study examined the effects of bright light therapy (BLT) on the incidence of delirium in post-operative patients admitted to a surgical intensive care unit (SICU) and delineates risk and protective factors. We included 62 patients in a single-blind, randomized controlled study. The intervention group was treated ...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2017.12.046
更新日期：2018-03-01 00:00:00
abstract：:The relationship between sleep architecture and attentional performance was evaluated in neuroleptic-naive patients with schizophrenia and healthy controls. Participants were recorded in a sleep laboratory for two consecutive nights after which selective and sustained attention performance was tested. In both groups o...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.11.005
更新日期：2007-01-15 00:00:00
abstract：:Neuropsychological performance was examined in a sample of 100 children between the ages of 6 and 18 years who met DSM-III-R criteria for Tourette's syndrome. Neuropsychological test scores were converted to age-corrected t scores based on published normative data. Ratings of Tourette's symptoms were also obtained. Th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90150-4
更新日期：1990-07-01 00:00:00
abstract：:Light falling on the retina is converted into an electrical signal which stimulates serotonin synthesis. Previous studies described an increase of plasma and CNS serotonin levels after bright light exposure. Ghrelin and leptin are peptide hormones which are involved in the regulation of hunger/satiety and are related ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.05.068
更新日期：2015-10-30 00:00:00
abstract：:Dewan asserted 20 years ago that a bedside light could shorten and regularize the menstrual cycle among women with long and irregular menstrual patterns. To replicate this, seven volunteers slept with a 100-watt bulb by the bedside from days 13-17 of their menstrual cycles, while nine controls similarly used a dim red...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(90)90067-f
更新日期：1990-08-01 00:00:00
abstract：:Cognitive deficits have been found to be more prevalent in psychotic than in other disorders. Longitudinal research has shown that these deficits were generally already existent before onset of illness and are therefore not necessarily attributable to neurodegenerative processes. This study investigated whether both l...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.05.035
更新日期：2013-11-30 00:00:00
abstract：:The current study was a systematic review examining probable posttraumatic stress disorder (PTSD) in first responders following man-made mass violence. A systematic literature search yielded 20 studies that fit the inclusion criteria. The prevalence rates of probable PTSD across all 20 studies ranged from 1.3% to 22.0...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2015.06.015
更新日期：2015-09-30 00:00:00
abstract：:Because two-thirds of patients with Major Depressive Disorder do not achieve remission with their first antidepressant, we designed a trial of three "next-step" strategies: switching to another antidepressant (bupropion-SR) or augmenting the current antidepressant with either another antidepressant (bupropion-SR) or w...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2015.08.005
更新日期：2015-10-30 00:00:00
abstract：:Tourette syndrome (TS) is a heritable disorder characterized by tics that are decreased in some patients by treatment with alpha adrenergic agonists and dopamine receptor blockers. Thus, this study examines the relationship between catecholamine gene expression in blood and tic severity. TS diagnosis was confirmed usi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.04.034
更新日期：2012-12-30 00:00:00
abstract：:Patients with schizophrenia exhibit reduced levels of both prepulse inhibition of the startle reflex (PPI) and condition-test suppression of the P50 event-related potential. This study investigated the extent to which PPI and P50 suppression, which exhibit similar parametric sensitivities, are intrinsically auditory p...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.11.002
更新日期：2006-08-30 00:00:00
abstract：:Hypersomnia is common in psychiatric disorders, yet there are few self-report measures that adequately characterize this sleep disturbance. The objective of this study was to validate the Hypersomnia Severity Index (HSI), a tool designed to measure severity, distress and impairment of hypersomnia in psychiatric popula...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.112547
更新日期：2019-11-01 00:00:00
abstract：:The antipsychotic effects of dopamine D2 receptor antagonists (neuroleptics) and the psychotomimetic effects of dopamine agonists suggest that a defect of the D2 receptor gene might be a factor in the etiology of schizophrenia. Fifteen families that contained several members suffering from schizophrenia were tested fo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(94)90111-2
更新日期：1994-08-01 00:00:00
abstract：:Diminished neural responses to punitive stimulus related to high level of pain avoidance may be biomarkers in distinguishing patients with history of suicide attempts from those without such histories. Outpatients with Major Depression Disorder (MDD, n=44) and healthy controls (HCs, n=28) were administered the Beck De...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113507
更新日期：2020-12-01 00:00:00
abstract：:Considerable disagreement exists about the neuroanatomical basis of conceptual-semantic impairments observed in a subgroup of patients with Alzheimer's disease (AD) at mild to moderate stages of the disease. Several studies of groups of patients have shown correlations between focal hypometabolism or hypoperfusion in ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2004.07.006
更新日期：2004-12-15 00:00:00
abstract：:Ten long-term abstinent alcoholics (mean abstinence = 7.7 years) were compared with 13 recently detoxified substance-dependent inpatients (mean abstinence = 25 days) and 8 nonalcoholic control subjects on global end regional measures of cortical cerebral blood flow (CBF), and on neuropsychological measures. CBF was as...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(96)02769-2
更新日期：1996-07-31 00:00:00
abstract：:This study examined the impact of bombing on posttraumatic stress disorder (PTSD) and psychiatric co-morbidity over time, whether this relationship was mediated by shattered world assumptions and altered self-capacities, and whether the mediational effects were moderated by attachment style and crisis support among Ir...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.01.001
更新日期：2019-03-01 00:00:00
abstract：:Childhood trauma exposure has been associated with a clinically relevant mixed phenotype of psychopathology composed of depressive, anxiety, and psychosis symptoms, across healthy and clinical samples. Altered stress-reactivity after exposure to childhood trauma may be a plausible underlying mechanism explaining this ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.12.012
更新日期：2018-02-01 00:00:00
abstract：:The current study aims to further evaluate the psychometric properties of the Maryland Assessment of Recovery in Serious Mental Illness (MARS), a relatively new instrument designed to assess personal recovery status in individuals with serious mental illness. Two hundred and fifty individuals with serious mental illne...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.03.031
更新日期：2016-05-30 00:00:00
abstract：:It has been reported that the balance between T-helper type 1 (Th1) cytokines and T-helper type 2 (Th2) cytokines plays a role in psychiatric disorders such as bipolar disorder. The T-helper type 3 (Th3) cytokine, which transforming growth factor beta-1 (TGF-beta1), has been shown to modulate the production of Th1 and...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2004.08.005
更新日期：2004-12-30 00:00:00
abstract：:Only few studies addressing the biological background of adjustment disorder (AD) exist. We examined the psychophysiological correlates indicative of autonomic regulation in AD. Heart rate variability (HRV), skin conductance, skin temperature, electromyography, and respiration were measured during serial stress tasks ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.12.065
更新日期：2018-03-01 00:00:00
abstract：:The aim of the present study was to investigate whether healthy first-degree relatives of schizophrenia patients show reduced sensitivity performance, higher intra-individual variability (IIV) in reaction time (RT), and a steeper decline in sensitivity over time in a sustained attention task. Healthy first-degree rela...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.12.012
更新日期：2010-05-15 00:00:00
abstract：:The goal of this study was to assess integrity of the cingulum bundle in patients diagnosed with first episode schizophrenia, chronic schizophrenia, and matched controls as well as to determine the relationship between diffusion measures of cingulum bundle integrity and severity of patients' delusions of reference. Pa...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.08.002
更新日期：2014-11-30 00:00:00
abstract：:Although social skills training (SST) is an effective approach for improving social skills for schizophrenia, the motivational deficit attenuates its efficacy. Virtual reality (VR) applications have allowed individuals with mental disabilities to enhance their motivation for rehabilitation. We compared SST using VR ro...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2011.04.003
更新日期：2011-09-30 00:00:00
abstract：:Preliminary data are presented on levels of plasma cortisol, dopamine (DA), epinephrine (EPI), and norepinephrine (NE) before and after dexamethasone in 22 depressed patients (of whom 4 were psychotic). Platelet monoamine oxidase (MAO) activity, determined in 19 of the depressed patients, was significantly higher in t...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(87)90007-2
更新日期：1987-02-01 00:00:00
abstract：:Since abnormalities in distal upper limb development are among the minor physical anomalies associated with schizophrenia we attempted to determine whether patients with schizophrenia can be identified on the basis of specific morphologic and dermatoglyphic features of the hand. Photographs and prints of the hands of ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.08.026
更新日期：2013-12-30 00:00:00
abstract：:Major depression (MD) is a common psychiatric disorder and one of its most serious symptoms is suicidal ideation. Six polymorphisms in four genes related to the serotonin system, including the HTTLPR and HTTVNTR in the SLC6A4 gene, rs6295 in the HTR1A gene, rs11568817 and rs130058 in the HTR1B gene, and rs6313 in the ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.12.006
更新日期：2009-12-30 00:00:00
abstract：:Conduct disorder (CD) symptom counts in preadolescent boys, and antisocial personality disorder (ASP) and childhood conduct disorder symptom counts in their parents, were used as dimensional measures of behavioral deviation. A significant correlation was found for CD and ASP symptom counts between the two parents and ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90003-y
更新日期：1993-01-01 00:00:00
