Abstract：
:Posttraumatic stress disorder (PTSD) is a severe psychiatric disorder prevalent in combat veterans. Previous neuroimaging studies have demonstrated that patients with PTSD exhibit abnormal responses to non-threatening visual and auditory stimuli, but have not examined somatosensory processing. Thirty male combat veterans, 16 with PTSD and 14 without, completed a tactile stimulation task during a 306-sensor magnetoencephalography (MEG) recording. Significant oscillatory neural responses were imaged using a beamforming approach. Participants also completed clinical assessments of PTSD, combat exposure, and depression. We found that veterans with PTSD exhibited significantly reduced activity during early (0-125 ms) tactile processing compared with combat controls. Specifically, veterans with PTSD had weaker activity in the left postcentral gyrus, left superior parietal area, and right prefrontal cortex in response to nonthreatening tactile stimulation relative to veterans without PTSD. The magnitude of activity in these brain regions was inversely correlated with symptom severity, indicating that those with the most severe PTSD had the most abnormal neural responses. Our findings are consistent with a resource allocation view of perceptual processing in PTSD, which directs attention away from nonthreatening sensory information.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Badura-Brack AS,Becker KM,McDermott TJ,Ryan TJ,Becker MM,Hearley AR,Heinrichs-Graham E,Wilson TWdoi
10.1016/j.pscychresns.2015.06.012subject
Has Abstractpub_date
2015-08-30 00:00:00pages
194-200issue
2eissn
0165-1781issn
1872-7123pii
S0925-4927(15)30023-8journal_volume
233pub_type
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