Abstract：
:In order to explore the neuropathology of the pre- and post-synaptic dopamine neurons of patients with major depression, we examined striatal D(2)/D(3) receptor uptake and dopamine transporter (DAT) availability simultaneously in drug-free depressed patients using a dual-isotope single photon emission computed tomography (SPECT) imaging technique. Ten unmedicated patients with unmediated depression and ten healthy controls were recruited. The striatal dopamine D(2)/D(3) receptor availability was measured using SPECT and [(123)I] IBZM, while DAT was measured using SPECT and [(99m)Tc] TRODAT-1. The symptom changes of the drug-free patients were reassessed after a 4-week antidepressant treatment. DAT binding in the patient group were significantly higher than in control group. That was not the case, however, for striatal D(2)/D(3) receptor availability. Pre-treatment striatal DAT availability correlated only marginally with changes in the Hamilton Depression Rating Scale after 4 weeks of treatment. Central dopamine functions may be altered in patients with major depression, particularly in the pre-synaptic sites.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Yang YK,Yeh TL,Yao WJ,Lee IH,Chen PS,Chiu NT,Lu RBdoi
10.1016/j.pscychresns.2007.08.008subject
Has Abstractpub_date
2008-04-15 00:00:00pages
230-5issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(07)00174-6journal_volume
162pub_type
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