Abstract：
:Structural neuroimaging studies of the amygdala and hippocampus in bipolar disorder have been largely inconsistent. This may be due in part to differences in the proportion of subjects taking lithium or experiencing an acute mood state, as both factors have recently been shown to influence gray matter structure. To avoid these problems, we evaluated euthymic subjects not currently taking lithium. Thirty-two subjects with bipolar type I disorder and 32 healthy subjects were scanned using magnetic resonance imaging. Subcortical regions were manually traced, and converted to three-dimensional meshes to evaluate the main effect of bipolar illness on radial distance. Statistical analyses found no evidence for a main effect of bipolar illness in either region, although exploratory analyses found a significant age by diagnosis interaction in the right amygdala, as well as positive associations between radial distance of the left amygdala and both prior hospitalizations for mania and current medication status. These findings suggest that, when not treated with lithium or in an acute mood state, patients with bipolar disorder exhibit no structural abnormalities of the amygdala or hippocampus. Future studies, nevertheless, that further elucidate the impact of age, course of illness, and medication on amygdala structure in bipolar disorder are warranted.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Foland-Ross LC,Thompson PM,Sugar CA,Narr KL,Penfold C,Vasquez RE,Townsend J,Fischer J,Saharan P,Bearden CE,Altshuler LLdoi
10.1016/j.pscychresns.2012.08.002subject
Has Abstractpub_date
2013-03-30 00:00:00pages
195-201issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(12)00186-2journal_volume
211pub_type
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