6-(18)F-DOPA PET study in patients with schizophrenia. Positron emission tomography.

Abstract:

:Presynaptic dopamine metabolism was studied in a group of patients with schizophrenia and in an age- and gender-matched normal control group using 6-[(18)F]fluoro-L-DOPA ((18)F-DOPA) and positron emission tomography (PET). Nineteen patients, nine drug-free, 10 on neuroleptics, and 13 normal control subjects underwent PET scans using (18)F-DOPA. The neuroleptic-treated patients were taking typical neuroleptics (N=4) or the atypical neuroleptic, clozapine (N=6). The ratio of specific/non-specific activity was calculated for eight cortical and subcortical regions of interest. Medication-free patients had a significant reduction in (18)F-DOPA uptake in the ventral striatum (P=0.04) and significantly increased uptake in the posterior cingulate (P=0.02) compared with normal control subjects. The 18F-DOPA PET technique proved to be useful and sensitive in detecting changes in dopamine metabolism in patients with schizophrenia in vivo. The results of this study provide evidence of an aberrant dopamine system in schizophrenia.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Elkashef AM,Doudet D,Bryant T,Cohen RM,Li SH,Wyatt RJ

doi

10.1016/s0925-4927(00)00064-0

subject

Has Abstract

pub_date

2000-11-20 00:00:00

pages

1-11

issue

1

eissn

0165-1781

issn

1872-7123

pii

S0925492700000640

journal_volume

100

pub_type

杂志文章
  • Personality traits related to monoamine oxidase activity in platelets.

    abstract::Platelet monoamine oxidase (MAO) activity and intellectual level were examined in a large series of 1,129 18-year-old boys, selected from the general population. Personality traits were determined by means of selected subscales from several personality inventories such as the Zuckerman Sensation Seeking Scale, the Eys...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(84)90134-3

    authors: von Knorring L,Oreland L,Winblad B

    更新日期:1984-05-01 00:00:00

  • White matter microstructure abnormalities and executive function in adolescents with prenatal cocaine exposure.

    abstract::Children with prenatal exposure to cocaine are at higher risk for negative behavioral function and attention difficulties, and have demonstrated brain diffusion abnormalities in frontal white matter regions. However, brain regions beyond frontal and callosal areas have not been investigated using diffusion tensor imag...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.pscychresns.2013.04.002

    authors: Lebel C,Warner T,Colby J,Soderberg L,Roussotte F,Behnke M,Davis Eyler F,Sowell ER

    更新日期:2013-08-30 00:00:00

  • Associations between trait anhedonia and emotional memory deficits in females with schizophrenia versus major depression.

    abstract::Individuals with schizophrenia (SZ) and individuals with major depressive disorder (MDD) demonstrate impaired emotional memory and decreased enjoyment of pleasant experiences (e.g., anhedonia). However, it is unclear whether these impairments reflect similar or different processes in the two diagnostic groups. This st...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2015.09.012

    authors: Olsen EK,Bjorkquist OA,Bodapati AS,Shankman SA,Herbener ES

    更新日期:2015-12-15 00:00:00

  • Olfactory identification deficits and associated response inhibition in obsessive-compulsive disorder: on the scent of the orbitofronto-striatal model.

    abstract::Olfactory identification ability implicates the integrity of the orbitofrontal cortex (OFC). The fronto-striatal circuits including the OFC have been involved in the neuropathology of Obsessive Compulsive Disorder (OCD). However, only a few studies have examined olfactory function in patients with OCD. The Brief Smell...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2013.05.032

    authors: Bersani G,Quartini A,Ratti F,Pagliuca G,Gallo A

    更新日期:2013-11-30 00:00:00

  • Reaction-time crossover in psychiatric outpatients.

    abstract::Simple reaction time (SRT) was measured in schizophrenic, bipolar affective disorder, and never-psychotic outpatients to determine the specificity of SRT crossover to schizophrenia. A crossover pattern like that reported in other studies was found among the schizophrenics, but the average curve was not different from ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(83)90084-7

    authors: Bohannon WE,Strauss ME

    更新日期:1983-05-01 00:00:00

  • Themes and trends in intentional self-poisoning: Perspectives from critical care toxicology.

    abstract::This research investigated the substances employed by and experiences of patients who come to acute treatment after self-poisoning. A retrospective search of the Toxicology Investigators Consortium Registry was performed to characterize a large cohort of patients. A detailed prospective study of one inpatient toxicolo...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2017.05.049

    authors: Rasimas JJ,Smolcic EE,Sinclair CM

    更新日期:2017-09-01 00:00:00

  • Social cognition and interaction training for major depression: A preliminary study.

    abstract::The present work investigated the efficacy of social cognition and interaction training (SCIT) for patients with major depression. Thirty first-episode patients with major depression who received the SCIT plus the treatment-as-usual (i.e., SCIT + TAU group) were compared with twenty-nine patients who only received tre...

    journal_title:Psychiatry research

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.psychres.2018.11.008

    authors: Zhu S,Zhu K,Jiang D,Shi J

    更新日期:2018-12-01 00:00:00

  • Demographic and clinical differences between early- and late-onset bipolar disorders in a multicenter study in China.

    abstract::Little is known about the demographic and clinical differences between early-onset (EOB) and late-onset bipolar disorders (LOB) in Chinese patients. This multi-center study examined the demographic and clinical characteristics of EOB (≤21 years) and LOB (>21 years) in China. A consecutively recruited sample of 555 pat...

    journal_title:Psychiatry research

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.psychres.2016.10.063

    authors: Zhang L,Yang HC,Xu XF,Fang YR,Yu X,Tan QR,Li HC,Ungvari GS,Ng CH,Wang G,Xiang YT

    更新日期:2016-12-30 00:00:00

  • Prevention of memory impairment induced by post-traumatic stress disorder by cerebrolysin.

    abstract::Post-traumatic stress disorder (PTSD) may occur after exposure to stressful, fearful or troubling events. Until now, there is no curable medication for this disorder. Cerebrolysin is a neuropeptide, which has an important role in the treatment of vascular dementia. In this study, the probable protective effect of cere...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2018.10.008

    authors: Alzoubi KH,Al-Ibbini AM,Nuseir KQ

    更新日期:2018-12-01 00:00:00

  • Plasma dopamine beta-hydroxylase activity in psychotic and non-psychotic post-traumatic stress disorder.

    abstract::Recognition and treatment of comorbid chronic psychotic symptoms in post-traumatic stress disorder (PTSD) has become of increasing clinical interest. Altered dopamine beta-hydroxylase (DBH) activity has been reported in mood disorders. Plasma DBH is reduced in major depression with psychosis and elevated in bipolar di...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/s0165-1781(98)00002-x

    authors: Hamner MB,Gold PB

    更新日期:1998-02-27 00:00:00

  • The real-life effectiveness of psychosocial therapies on social autonomy in schizophrenia patients: Results from a nationwide cohort study in France.

    abstract::The objectives of the present study were to describe the prescribing patterns for psychosocial therapies in routine clinical practice and to assess the impact of psychoeducation on symptoms and social autonomy of patients with schizophrenia. We used data from the nationwide French ESPASS observational cohort study inc...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2016.10.048

    authors: Ali A,Carre A,Orri M,Urbach M,Barry C,Hassler C,Falissard B,Berthoz S,Nordon C

    更新日期:2017-01-01 00:00:00

  • Predicting the length of hospital stay of psychiatry patients using signal detection analysis.

    abstract::In Japan, the length of hospital stay (LOS) at psychiatric institutions often exceeds a year, and factors related to such stays have been identified. However, we do not know how multiple patient, hospital, and physician factors interact to determine LOS. Patient data were collected from a psychiatric hospital in Osaka...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2013.09.019

    authors: Badriah F,Abe T,Nabeshima Y,Ikeda K,Kuroda K,Hagihara A

    更新日期:2013-12-30 00:00:00

  • Parametric study of accuracy and response time in schizophrenic persons making visual or auditory discriminations.

    abstract::The inability to modulate processing time in conjunction with varying difficulty levels may be a core component of schizophrenia's cognitive deficit. In this study we used a parametric design to demonstrate this group's inability to increase and decrease response times in association with varying levels of task demand...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2004.04.003

    authors: Holcomb HH,Parwani A,McMahon RP,Medoff DR,Frey K,Lahti AC,Tamminga CA

    更新日期:2004-07-15 00:00:00

  • Validity and reliability of a scale to assess fatigue.

    abstract::A visual analogue scale to evaluate fatigue severity (VAS-F) was developed and tested in a sample of 75 healthy individuals and a sample of 57 patients undergoing medical evaluation for sleep disorders. The scale consists of 18 items related to fatigue and energy, has simple instructions, and is completed with minimal...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(91)90027-m

    authors: Lee KA,Hicks G,Nino-Murcia G

    更新日期:1991-03-01 00:00:00

  • Delusional themes in Body Dysmorphic Disorder (BDD): Comparisons with psychotic disorders and non-clinical Controls.

    abstract::The prevailing nosological classification of body dysmorphic disorder (BDD) encompasses an optional specifier "with absent insight/delusional beliefs" for patients who hold high conviction of the veracity of their disorder-specific beliefs. Yet limited research has examined the explicit nature of delusional beliefs in...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2019.112694

    authors: Rossell SL,Labuschagne I,Castle DJ,Toh WL

    更新日期:2020-02-01 00:00:00

  • Emotion recognition, 'theory of mind,' and social behavior in schizophrenia.

    abstract::Several studies have demonstrated that patients with schizophrenia are impaired in recognizing emotions from facial expressions and in appreciating other people's mental states--the latter commonly referred to as 'theory of mind.' The question as to how social cognitive skills relate to patients' actual social behavio...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2004.10.007

    authors: Brüne M

    更新日期:2005-02-28 00:00:00

  • Platelet glutathione peroxidase and monoamine oxidase activity in schizophrenics with CT scan abnormalities: relation to psychosocial variables.

    abstract::We have previously reported that the activity in platelets of the important antioxidant enzyme glutathione peroxidase (GPx) is inversely correlated with computed tomographic (CT) measures of brain atrophy in a population of patients with chronic schizophrenia, suggesting that low GPx may be a vulnerability factor in t...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(90)90103-c

    authors: Buckman TD,Kling A,Sutphin MS,Steinberg A,Eiduson S

    更新日期:1990-01-01 00:00:00

  • Psychomotor performance and fitness to drive: the influence of psychiatric disease and its pharmacological treatment.

    abstract::Both psychiatric disorders and psychiatric drug treatments produce changes of psychomotor performance which can disturb and/or interfere with the ability to drive safely. We studied the influence of current psychiatric drug treatments on psychomotor functions and on driving performance of 77 consecutive psychiatric ou...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2009.02.013

    authors: De Las Cuevas C,Ramallo Y,Sanz EJ

    更新日期:2010-04-30 00:00:00

  • Effectiveness of electroconvulsive therapy in patients with treatment resistant schizophrenia: A retrospective study.

    abstract::This study aimed to evaluate the effectiveness of electroconvulsive therapy (ECT) among patients with treatment resistant schizophrenia (TRS). Records of patients who had received ECT were reviewed to identify patients with TRS who were administered ECT in combination with clozapine. Socio-demographic, clinical data a...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2017.01.042

    authors: Grover S,Chakrabarti S,Hazari N,Avasthi A

    更新日期:2017-03-01 00:00:00

  • Relationship between PTSD and pathological personality traits in context of disasters.

    abstract::One of the recurrent outcomes after a stressor event as a disaster is post-traumatic stress disorder (PTSD), which appears to be mediated, in part, by emotional, behavioral, and psychological responses, arising from the belief system associated with the traumatic experience. Studies suggest that personality traits are...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2016.04.099

    authors: Reis AM,de Francisco Carvalho L,Elhai JD

    更新日期:2016-07-30 00:00:00

  • Risk indicators for post-traumatic stress disorder in adolescents exposed to the 5.12 Wenchuan earthquake in China.

    abstract::In Chinese adolescents exposed to the Wenchuan earthquake, we used the Children's Revised Impact of Event Scale (CRIES) as the screening tool, and Post-traumatic Cognitions Inventory (PTCI) and the Social Support Rating Scale (SSRS) were used to assess the cognitive status and their social supports, to evaluate the pr...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2010.12.016

    authors: Ma X,Liu X,Hu X,Qiu C,Wang Y,Huang Y,Wang Q,Zhang W,Li T

    更新日期:2011-10-30 00:00:00

  • Dissociation, memory commission errors, and heightened autonomic reactivity.

    abstract::If dissociative symptoms are manifestations of a psychological defense mechanism, one would expect people who have such symptoms to react with lower levels of physiological arousal and with memory omissions to emotionally provocative material. The current study tested this assumption in a sample of undergraduates. Six...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2006.04.016

    authors: Giesbrecht T,Geraerts E,Merckelbach H

    更新日期:2007-04-15 00:00:00

  • Factors related to different reasons for antipsychotic drug discontinuation in the treatment of schizophrenia: a naturalistic 18-month follow-up study.

    abstract::In recent years, measurement of the effectiveness of antipsychotic therapy in schizophrenia has received increasing attention from clinicians and researchers. Several studies have used time to antipsychotic discontinuation for any reason as a global index of antipsychotic effectiveness because it reflects both the phy...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2012.07.006

    authors: Vita A,Barlati S,Deste G,Corsini P,De Peri L,Sacchetti E

    更新日期:2012-12-30 00:00:00

  • Preliminary effects of bupropion and the promoter region (HTTLPR) serotonin transporter (SLC6A4) polymorphism on smoking behavior in schizophrenia.

    abstract::In the current study, we investigated how individual variants in the serotonin promoter gene, previously associated with smoking cessation and linked to anxiety-related personality traits, were associated with individual differences in responsiveness to bupropion and cognitive behavioral therapy (CBT) in a clinical po...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.psychres.2008.12.015

    authors: Bloch B,Reshef A,Cohen T,Tafla A,Gathas S,Israel S,Gritsenko I,Kremer I,Ebstein RP

    更新日期:2010-01-30 00:00:00

  • Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients.

    abstract::Depression is associated with a lowered degree of esterification of serum cholesterol, an increased C20:4omega6/C20:5omega3 ratio and decreases in omega3 fractions in fatty acids (FAs) or in the red blood cell membrane. The aims of the present study were to examine: (i) serum phospholipid and cholesteryl ester composi...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0165-1781(99)00014-1

    authors: Maes M,Christophe A,Delanghe J,Altamura C,Neels H,Meltzer HY

    更新日期:1999-03-22 00:00:00

  • PTSD, social anxiety disorder, and trauma: An examination of the influence of trauma type on comorbidity using a nationally representative sample.

    abstract::Posttraumatic stress disorder (PTSD) and social anxiety disorder (SAD) are highly comorbid (Collimore et al., 2010). Trauma may present a shared environmental factor contributing to the development of comorbidity; however, existent research has been hampered by use of restrictive samples and limitations in the range o...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2016.10.036

    authors: McMillan KA,Asmundson GJG

    更新日期:2016-12-30 00:00:00

  • Mindfulness-based cognitive therapy for bipolar disorder: A systematic review and meta-analysis.

    abstract:BACKGROUND:Mindfulness-based cognitive therapy (MBCT) is an increasingly popular treatment for major depression and anxiety disorder, but has shown inconsistent efficacy for bipolar disorder (BD). Therefore, we conducted a meta-analysis to assess the general efficacy of MBCT for BD. METHODS:Ten studies were identified...

    journal_title:Psychiatry research

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.psychres.2020.113116

    authors: Xuan R,Li X,Qiao Y,Guo Q,Liu X,Deng W,Hu Q,Wang K,Zhang L

    更新日期:2020-08-01 00:00:00

  • An investigation of the effect of social reciprocity, social anxiety, and letter fluency on communicative behaviors in adults with autism spectrum disorder.

    abstract::In recent years, research focusing on childhood has reported that communication difficulties in autism spectrum disorder (ASD) are related to the social reciprocity difficulties inherent to ASD, as well as severe social anxiety and decreased verbal fluency. However, there have been no reports regarding these correlati...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2020.113503

    authors: Kimura Y,Fujioka T,Jung M,Fujisawa TX,Tomoda A,Kosaka H

    更新日期:2020-12-01 00:00:00

  • Preliminary validation of a set of content analysis scales applicable to verbal samples for measuring the magnitude of psychological states in children.

    abstract::Scores on 17 psychological dimensions of the Gottschalk-Gleser content analysis scales were obtained from 5-minute speech samples of 37 white children hospitalized on the psychiatric service of a general hospital. These content analysis scores were compared to identical scores obtained from a normative sample of 109 w...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(79)90030-1

    authors: Gottschalk LA,Uliana RL,Hoigaard JC

    更新日期:1979-07-01 00:00:00

  • Quality of life in Chinese patients with schizophrenia: A meta-analysis.

    abstract::The impact of schizophrenia on quality of life (QOL) is significantly influenced by sociocultural factors. This meta-analysis systematically compared QOL between patients with schizophrenia and healthy controls in China. PubMed, PsycINFO, Embase, Chinese National Knowledge Infrastructure (CNKI), SinoMed and WanFang da...

    journal_title:Psychiatry research

    pub_type: 杂志文章,meta分析

    doi:10.1016/j.psychres.2018.07.003

    authors: Lu L,Zeng LN,Zong QQ,Rao WW,Ng CH,Ungvari GS,Li J,An FR,Xiang YT

    更新日期:2018-10-01 00:00:00