Abstract:
:The main goal in the treatment of major depressive disorder (MDD) is to achieve remission, defined as the resolution of symptoms and the return to normal levels of functionality. However, the clinical assessment of remission is usually merely based on scores of symptomatic rating scales. One of the most widely used scales to measure remission is the HAM-D(17), in which remission is defined as a score ≤ 7. Nevertheless, several studies have shown that this cutoff could be too high when also functioning is considered. This is a post-hoc analysis of a 6-month prospective study, performed over a sample of 292 Spanish patients with MDD, in order to find the optimal cutoff in the HAM-D(17) scale, considering normal levels of functionality, evaluated by the SOFAS; by means of plotting Receiver Operating Characteristics (ROC) curves. Our results show that a score of ≤ 5 maximized both sensitivity and specificity for identifying normal levels of functionality with respect to other scores, and thus agree with previous works, which suggest that a cutoff ≤ 7 might be too high to consider remission in patients with MDD, when normal levels of functioning are taken into account.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Romera I,Pérez V,Menchón JM,Polavieja P,Gilaberte Idoi
10.1016/j.psychres.2010.06.023subject
Has Abstractpub_date
2011-03-30 00:00:00pages
133-7issue
1eissn
0165-1781issn
1872-7123pii
S0165-1781(10)00365-3journal_volume
186pub_type
杂志文章,多中心研究abstract::In this longitudinal study we compared brain volume changes in first- and multiple-episode patients with schizophrenia to normal aging changes observed in healthy control subjects scanned at comparable times. Two to four years after an initial examination including MRI volumetry, we followed up 21 first episode patien...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2005.07.006
更新日期:2005-12-30 00:00:00
abstract::Only little is known about pathological personality traits in patients with Gilles de la Tourette syndrome (GTS). The aim of this study was to further investigate the prevalence of personality traits in adults with GTS. We used a variety of rating scales to assess not only personality traits, but also severity of tics...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.04.043
更新日期:2015-08-30 00:00:00
abstract::The cognitive significance of P300 abnormalities in schizophrenia and obsessive-compulsive disorder (OCD) was investigated. P300 was measured by an auditory oddball paradigm, in which a series of standard tones (1000 Hz) and target tones (1500 Hz) were presented. The subject's task was to count the number of the prese...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(03)00045-3
更新日期:2003-06-30 00:00:00
abstract::We analyzed the potential influence of family relationships and history of psychiatric disorders on the presentation and course of early psychotic disorders. We recruited 110 subjects aged 9-17 years with a first psychotic episode and 98 matched healthy controls, and followed them for 1 year. Data were collected throu...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2009.12.007
更新日期:2011-01-30 00:00:00
abstract::The antipsychotic effects of dopamine D2 receptor antagonists (neuroleptics) and the psychotomimetic effects of dopamine agonists suggest that a defect of the D2 receptor gene might be a factor in the etiology of schizophrenia. Fifteen families that contained several members suffering from schizophrenia were tested fo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(94)90111-2
更新日期:1994-08-01 00:00:00
abstract::Dissociative disorders are frequent comorbid conditions of other mental disorders. Yet, there is controversy about their clinical relevance, and little systematic research has been done on how they influence global functioning. Outpatients and day care patients (N=160) of several psychiatric units in Switzerland were ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.04.028
更新日期:2012-12-30 00:00:00
abstract::Perceived Criticism (PC) evolved in the context of Expressed Emotion (EE) research and, like EE, predicts the course of various psychiatric disorders. However, little is known about PC's validity. We examined (in Study 1) to what extent PC reflects the perceiver's current depressive and marital complaints, whether PC ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2008.09.007
更新日期:2009-12-30 00:00:00
abstract::Two measures of negative schizophrenic symptoms, the Scale for the Assessment of Negative Symptoms and the withdrawal-retardation subscale of the Brief Psychiatric Rating Scale, are found to be redundant when used together. Studies incorporating redundant measures have numerous disadvantages. Using multiple scales inc...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(87)90122-3
更新日期:1987-01-01 00:00:00
abstract::Glucocorticoids (GCs) have repeatedly been shown to impair hippocampus-mediated, declarative memory retrieval and prefrontal cortex-based working memory in healthy subjects. However, recent experimental studies indicated that patients with major depressive disorder (MDD) lack these impairing effects. These missing eff...
journal_title:Psychiatry research
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.psychres.2012.12.019
更新日期:2013-10-30 00:00:00
abstract::We examined associations between social connections and non-suicidal self-injury (NSSI) among transgender/gender non-conforming (TGNC) youth. Data came from the 2016 Minnesota Student Survey (N = 2168). Logistic regression analyses determined connectedness factors associated with any past-year NSSI and repetitive NSSI...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.06.068
更新日期:2018-10-01 00:00:00
abstract::A novel magnetic resonance imaging method was used to determine whether it is feasible to detect early signs of cortical atrophy among individuals who are at high risk for developing schizophrenia. Fifteen individuals at high-risk for schizophrenia and 15 of their first degree relatives diagnosed with schizophrenia we...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2006.04.010
更新日期:2006-11-22 00:00:00
abstract::Presynaptic dopamine metabolism was studied in a group of patients with schizophrenia and in an age- and gender-matched normal control group using 6-[(18)F]fluoro-L-DOPA ((18)F-DOPA) and positron emission tomography (PET). Nineteen patients, nine drug-free, 10 on neuroleptics, and 13 normal control subjects underwent ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(00)00064-0
更新日期:2000-11-20 00:00:00
abstract::We investigated the blood levels of mixed-lineage leukemia 1 (MLL1) mRNA and BDNF (brain derived neurotrophic factor) exon IV promoter on histone Histone 3 lysine 4 trimethylation (H3K4me3) in peripheral blood of patients with schizophrenia and controls. Over one year, 36 patients with schizophrenia and 32 controls we...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2016.06.010
更新日期:2016-09-30 00:00:00
abstract::Depression is associated with cognitive impairment and suicidality. The independent association between cognitive impairment and suicidality is less clear. We examined the relationship between suicidal ideation and cognitive impairment in a sample of 50 veterans with depressive disorder diagnoses. Using zero-inflated ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.112833
更新日期:2020-01-30 00:00:00
abstract::Schema theory and therapy may be an additional therapeutic approach to identify and treat chronic psychological problems, namely early maladaptive schemas (EMSs), in patients with obsessive-compulsive disorder (OCD) and panic disorder (PAD). In the current study, we investigated the characteristics in EMSs between pat...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2015.11.015
更新日期:2015-12-30 00:00:00
abstract::This report describes a computer program for applying a new statistical method for determining levels of agreement, or reliability, when multiple examiners evaluate a single subject. The statistics that are performed include the following: an overall level of agreement, expressed as a percentage, that takes into accou...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0165-1781(97)00093-0
更新日期:1997-08-29 00:00:00
abstract::Little is known about the relationship between precollege school bullying and murder-related psychological behaviors. The present study aims to examine that relationship in Chinese college students using a cross-sectional study. Self-report data were collected from 4034 college students in Anhui Province using a propo...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2019.112593
更新日期:2019-12-01 00:00:00
abstract::The aim of this exploratory study was to investigate facial affect in adolescent females with anorexia nervosa (AN). Evoked facial affect was recorded whilst AN and control participants (n=34) viewed emotional films. Significantly less facial affect was found in AN adolescents, despite reporting no differences in subj...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.07.057
更新日期:2014-12-15 00:00:00
abstract::Neurobiological abnormalities in various brain regions, including the orbitofrontal cortex, basal ganglia, and thalamus, have been found in patients with obsessive-compulsive disorder (OCD), and impairment in white matter connectivity in these regions has recently been suggested. To investigate structural connectivity...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.pscychresns.2010.12.003
更新日期:2011-06-30 00:00:00
abstract::There is increasing evidence that obsessive-compulsive disorder (OCD) is mediated by genetic factors. Although the precise mechanism of inheritance is unclear, recent evidence has pointed towards the involvement of the serotonergic and dopaminergic systems in the disorder's development. Furthermore, early-onset OCD ap...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2004.05.007
更新日期:2004-09-30 00:00:00
abstract::Evaluating whether certain subtypes of Major Depressive Disorder (MDD) are more strongly associated with Substance Use Disorders (SUDs) may help clarify reasons for MDD-SUD relations. Therefore, this study compared DSM-IV-defined non-atypical/non-melancholic depression (undifferentiated depression; n=365), atypical de...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2007.10.014
更新日期:2008-10-30 00:00:00
abstract::Family environmental variables are risk factors for recurrent courses of mood disorder in adolescents. The present study examined the association between parental expressed emotion (EE)-critical, hostile and/or emotionally overinvolved attitudes toward a concurrently ill offspring-and suicidal ideation in adolescents ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2014.02.013
更新日期:2014-05-15 00:00:00
abstract::Recent investigations suggest that serotonergic mechanisms modulate dimensions of personality, in particular decreases in Anger-Hostility and increases in Affiliation. None of these studies, however, demonstrated a specific serotonergic effect on personality, as other neurotransmitter systems have not been assessed fo...
journal_title:Psychiatry research
pub_type: 临床试验,杂志文章
doi:10.1016/s0165-1781(99)00041-4
更新日期:1999-06-30 00:00:00
abstract::Performance on neuropsychological tasks was compared in 15 subjects with obsessive-compulsive disorder (OCD) and 15 age- and sex-matched psychiatrically screened control subjects. The tasks chosen are known from studies in other patient groups to demonstrate lateralized abnormalities of visual and limited capacity att...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/0165-1781(93)90104-o
更新日期:1993-11-01 00:00:00
abstract::This study assessed how well longitudinally taken cognitive and functional scales from people with mild cognitive impairment (MCI) predict conversion to Alzheimer's disease (AD). Participants were individuals with baseline MCI from the Alzheimer's Disease Neuroimaging Initiative. Scales included the Alzheimer Disease ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2020.113201
更新日期:2020-09-01 00:00:00
abstract::Up to 90% of individuals with schizophrenia suffer from nicotine dependence. Both schizophrenia and nicotine consumption have strong genetic components, which may overlap. The relationship between schizophrenia and nicotine dependence remains unclear, due in part to confounding factors. Studies of the relationship bet...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2012.07.054
更新日期:2012-12-30 00:00:00
abstract::Implementation science has been recognized as a potential catalyst for health system reform, in part, because of its contribution of well-grounded conceptual theories, often encapsulated in frameworks. Well-designed frameworks provide a semantic structure, a common language by which to guide systematic approaches to s...
journal_title:Psychiatry research
pub_type: 杂志文章,评审
doi:10.1016/j.psychres.2019.06.036
更新日期:2020-01-01 00:00:00
abstract::Behavioral and biochemical studies in animals indicate that central dopaminergic neurotransmission may be modulated by sex steroids. This may be the mechanism underlying the suggested association between estrogen and schizophrenia. The aim was to examine if different levels of sex steroids during the menstrual cycle a...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/s0925-4927(98)00021-3
更新日期:1998-07-15 00:00:00
abstract::Post-traumatic stress disorder (PTSD) may occur after exposure to stressful, fearful or troubling events. Until now, there is no curable medication for this disorder. Cerebrolysin is a neuropeptide, which has an important role in the treatment of vascular dementia. In this study, the probable protective effect of cere...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2018.10.008
更新日期:2018-12-01 00:00:00
abstract::While considerable data support the relationship between childhood trauma and adult personality pathology in general, there is little research investigating the specific relationships between different types of childhood maltreatment and adult personality disorders. The present study tested a model incorporating five ...
journal_title:Psychiatry research
pub_type: 杂志文章
doi:10.1016/j.psychres.2013.10.036
更新日期:2014-01-30 00:00:00