Abstract：
:Seventeen obsessive-compulsive disorder (OCD) patients and 25 normal control subjects submitted 24-hour urine samples for measurement of urinary free cortisol (UFC). Thirteen of the 17 OCD patients submitted a second 24-hour urine collection after a 10-week trial of either clomipramine (n = 6) or placebo (n = 7). At baseline, the OCD patients had significantly higher UFC levels than the control group. After 10 weeks of clomipramine or placebo, however, the UFC levels for both OCD groups decreased and were comparable with those of the control group. Obsessive-compulsive symptomatology, as assessed by the Yale-Brown and the NIMH Global Obsessive-Compulsive Scales, improved in the clomipramine group but did not improve in the placebo group. There was a relationship between UFC levels and depressive symptoms.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Gehris TL,Kathol RG,Black DW,Noyes R Jrdoi
10.1016/0165-1781(90)90081-fsubject
Has Abstractpub_date
1990-05-01 00:00:00pages
151-8issue
2eissn
0165-1781issn
1872-7123pii
0165-1781(90)90081-Fjournal_volume
32pub_type
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