Caffeine taste test for panic disorder: adenosine receptor supersensitivity.

Abstract:

:The present study introduces a novel measure of adenosine receptor sensitivity that is based on the action of specific receptor blockers (e.g., caffeine) to potentiate the ability to detect threshold quinine concentrations. The test is used to compare gustatory adenosinergic responses to caffeine challenges in normal controls and patients with panic disorder or posttraumatic stress disorder (PTSD). Panic disorder patients had an exaggerated response to the caffeine challenge that was not found in controls or PTSD patients, although the latter had higher anxiety scores on psychometric tests. The results are related to a model in which A1-adenosine receptors up-regulate in an attempt to modulate hyperactive excitatory neuronal systems.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

DeMet E,Stein MK,Tran C,Chicz-DeMet A,Sangdahl C,Nelson J

doi

10.1016/0165-1781(89)90014-0

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

231-42

issue

3

eissn

0165-1781

issn

1872-7123

pii

0165-1781(89)90014-0

journal_volume

30

pub_type

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