Abstract：
:The present study introduces a novel measure of adenosine receptor sensitivity that is based on the action of specific receptor blockers (e.g., caffeine) to potentiate the ability to detect threshold quinine concentrations. The test is used to compare gustatory adenosinergic responses to caffeine challenges in normal controls and patients with panic disorder or posttraumatic stress disorder (PTSD). Panic disorder patients had an exaggerated response to the caffeine challenge that was not found in controls or PTSD patients, although the latter had higher anxiety scores on psychometric tests. The results are related to a model in which A1-adenosine receptors up-regulate in an attempt to modulate hyperactive excitatory neuronal systems.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
DeMet E,Stein MK,Tran C,Chicz-DeMet A,Sangdahl C,Nelson Jdoi
10.1016/0165-1781(89)90014-0subject
Has Abstractpub_date
1989-12-01 00:00:00pages
231-42issue
3eissn
0165-1781issn
1872-7123pii
0165-1781(89)90014-0journal_volume
30pub_type
杂志文章abstract：:The impact of stressful experiences during gestation or early life, leading to increased psychiatric disorders susceptibility, is currently well described in literature, however, few data are available on the association between obstetrical complications and later development of specific diagnoses or clinical features...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.05.014
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abstract：:Twenty-three patients meeting DSM-III criteria for agoraphobia with panic attacks and 14 age-, race-, and sex-matched nonanxious controls were tested in the laboratory and on a test walk in a shopping mall. The patients were tested before and after about 15 weeks of treatment with placebo and exposure therapy, imipram...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(88)90145-x
更新日期：1988-04-01 00:00:00
abstract：:Previous studies have identified global associations between sleep quality and suicidal ideation. However, little is known regarding the relationship between sleep quality and suicidal ideation among Chinese older adults. We examined the relationship between sleep quality and suicidal ideation in older adults in China...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.07.017
更新日期：2017-10-01 00:00:00
abstract：:Earlier neuroimaging studies of working memory (WM) have demonstrated that dorsolateral prefrontal cortex (DLPFC) activity increases as maintenance and load demand increases. However, few studies have carefully disambiguated these two WM processes at the behavioral and physiological levels. The objective of the presen...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2006.08.002
更新日期：2007-02-28 00:00:00
abstract：:In this study, we evaluated the efficacy of mindfulness-based stress reduction (MBSR) for young people with anxiety symptoms. We used many databases, including PubMed, PsycINFO, Web of Science, EMBASE, CINAHL and Cochrane Library (from inception to May 2019). We included randomized controlled trials (RCTs) comparing M...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2020.113002
更新日期：2020-07-01 00:00:00
abstract：:Correlations between normalized regional cerebral metabolic rates for glucose, determined by positron emission tomography with 18F-2-fluoro-2-deoxy-D-glucose, were used to investigate functional associations between pairs of brain regions in 18 adult patients with primary obsessive-compulsive disorder (OCD) of childho...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0925-4927(91)90014-h
更新日期：1991-12-01 00:00:00
abstract：:Recent studies show that higher-order appetitive neural circuitry may contribute to restricted eating in anorexia nervosa (AN) and overeating in bulimia nervosa (BN). The purpose of this study was to determine whether sensitization effects might underlie pathologic eating behavior when a taste stimulus is administered...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2015.10.010
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abstract：:Obstetric complications (OCs) are consistently implicated in the aetiology of schizophrenia. Information about OCs is often gathered retrospectively, from maternal interview. It has been suggested that mothers of people with schizophrenia may not be accurate in their recollection of obstetric events. We assessed the v...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.01.013
更新日期：2011-05-30 00:00:00
abstract：:Millions of people have been impacted by the novel coronavirus (COVID-19) pandemic worldwide. High infection rates and death tolls, combined with social distancing measures, may have unintended psychological consequences on individuals. The goal of this study was to examine the interrelations between COVID-19 exposure...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113699
更新日期：2020-12-30 00:00:00
abstract：:Using lexical content analysis (linguistic inquiry and word count), the hypotheses that social detachment and impaired cognitive processing are typical for alexithymia are investigated. Based on clinical interviews with 32 outpatients (mixed diagnoses), we found support for the hypotheses for the externally oriented t...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.06.032
更新日期：2011-11-30 00:00:00
abstract：:Deficient inhibitory neurotransmission of gamma-aminobutyric acid (GABA) has been implicated in the pathophysiology of schizophrenia based on postmortem studies. However, in vivo studies have shown predominantly negative or conflicting results. The goal of this study was to better characterize possible changes of the ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(99)00027-x
更新日期：1999-10-11 00:00:00
abstract：:While psychotherapies are of established value, they may, as active treatments, risk adverse outcomes. As there is no validated measure of potentially negative psychotherapeutic ingredients, we sought to develop such a measure for use in psychotherapy evaluation studies. Based on a review of the literature, a 103-item...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.11.026
更新日期：2013-04-30 00:00:00
abstract：:Clinical research across the developmental spectrum increasingly reveals the nuanced ways in which emotion and cognition can work to either support or derail rational (i.e., healthy or goal-consistent) decision making. However, psychological theories offer discrepant views on how these processes interact, and on wheth...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2019.01.048
更新日期：2019-03-01 00:00:00
abstract：:Suicidal behavior is a major health risk in psychiatric disorders, especially in schizophrenia, wherein up to 10% patients will commit suicide. However, the neurobiology of suicide is still unclear. Suicidality has been related to decreased central serotonergic (5-hydroxytryptamine, 5-HT) function and reduced choleste...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.08.012
更新日期：2007-02-28 00:00:00
abstract：:Social separation is a risk factor for major depressions that can be modeled in nonhuman primates. Changes in central monoamine neurotransmission are also likely to be involved in major depression. This study examined the relationship between separation-induced depressive-like behavior and central monoamine neurotrans...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(84)90004-0
更新日期：1984-04-01 00:00:00
abstract：:The interplay between Callous Unemotional Traits (CU) and Moral Disengagement (MD) was examined in a sample of 90 adolescents with Disruptive Behavior Disorders. Using a person-centered approach, three CU and MD configurations were identified, attesting the strong relationship between these two moral dimensions. Howev...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.043
更新日期：2017-12-01 00:00:00
abstract：:Deficit and non-deficit subtypes were examined for their concordance in 83 sibling pairs of 109 schizophrenic patients belonging to 46 multiply affected families. Using a sib-pair method, we have found that the distribution of deficit and non-deficit syndromes in sibling pairs of schizophrenic patients differed signif...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(01)00248-7
更新日期：2001-05-10 00:00:00
abstract：:Family, adoption, and twin studies have demonstrated the involvement of genetic factors in the etiology of major affective disorders. In an attempt to identify the involved genes, several linkage and association studies have focused on the gene coding for tyrosine hydroxylase, the rate-limiting enzyme in catecholamine...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(96)02888-0
更新日期：1996-09-27 00:00:00
abstract：:In this longitudinal study we compared brain volume changes in first- and multiple-episode patients with schizophrenia to normal aging changes observed in healthy control subjects scanned at comparable times. Two to four years after an initial examination including MRI volumetry, we followed up 21 first episode patien...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2005.07.006
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.11.001
更新日期：2019-01-01 00:00:00
abstract：:Prior studies found small effects of chronic smoking on spatial and color vision, but they were inconclusive. This study tries to: (1) replicate and extend these previous findings, and (2) rule in that this relationship is pronounced by tobacco addiction. Data were recorded in 71 healthy controls (M = 33.5 years; SD =...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.11.024
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(90)90103-c
更新日期：1990-01-01 00:00:00
abstract：:Depression rates are increasing among minors. Internet is central to the lives of many minors, and many of them look online for depression information. This report describes minors who attempted to screen themselves for depression in a worldwide online study. Google Ads were used to recruit individuals to a multilingu...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113250
更新日期：2020-09-01 00:00:00
abstract：:This study examined care pathways, program engagement, and key outcomes associated with a sub-acute inpatient stay in a 20-bed stand-alone Intermediate Stay Mental Health Unit (ISMHU; NSW, Australia). A 6-week evidenced-based tailored intervention program was offered, utilizing a recovery-oriented model of care. Servi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.112889
更新日期：2020-02-20 00:00:00
abstract：:Thirteen medication-free chronic schizophrenic patients and 11 normal control subjects were administered a trial by trial version of the Stroop Color Naming Task which evaluated separately the processes of interference and facilitation. There was no difference between the groups in the amount of interference to naming...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(92)90105-c
更新日期：1992-02-01 00:00:00
abstract：:This report presents the simultaneous pattern of cerebral blood flow and cerebral glucose metabolism in two patients with a major depressive disorder who were undergoing continuation ECT. The regional cerebral blood flow and regional cerebral metabolic rate of these patients were imaged using double isotope 18F-FDG an...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(03)00077-5
更新日期：2003-11-30 00:00:00
abstract：:Few investigations have assessed the neuropsychological effects of psychotropic medications on schizophrenic patients. In this study, 44 clinically stable schizophrenic inpatients were administered a battery of neuropsychological tests, and their performance was correlated with dosage of neuroleptic medication and ben...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90065-w
更新日期：1991-06-01 00:00:00
abstract：:Psychopathy is a cluster of personality traits associated with high rates of aggression. While research on psychopathic traits largely focuses on neurobiological factors implicated in aggression, other research suggests that contextual factors, such as social exclusion, also contribute to promoting aggression. Yet, th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.07.024
更新日期：2018-10-01 00:00:00
abstract：:Although Adjustment Disorder as a diagnostic category is widely used in clinical practice it is critically discussed that it has not been conceptualized as a category with unique symptoms. Hence, the conceptualization of Adjustment Disorder is subject to substantive change in ICD-11 including core symptoms and additio...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.07.010
更新日期：2015-10-30 00:00:00
abstract：:Social anhedonia is a promising indicator for the vulnerability towards developing schizophrenia-spectrum disorders and is an important determinant of the social impairment associated with these disorders. It is unknown if social anhedonia is associated with true deficits in experiential reactions or if lower social f...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.07.050
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