Caffeine taste test for panic disorder: adenosine receptor supersensitivity.


:The present study introduces a novel measure of adenosine receptor sensitivity that is based on the action of specific receptor blockers (e.g., caffeine) to potentiate the ability to detect threshold quinine concentrations. The test is used to compare gustatory adenosinergic responses to caffeine challenges in normal controls and patients with panic disorder or posttraumatic stress disorder (PTSD). Panic disorder patients had an exaggerated response to the caffeine challenge that was not found in controls or PTSD patients, although the latter had higher anxiety scores on psychometric tests. The results are related to a model in which A1-adenosine receptors up-regulate in an attempt to modulate hyperactive excitatory neuronal systems.


Psychiatry Res


Psychiatry research


DeMet E,Stein MK,Tran C,Chicz-DeMet A,Sangdahl C,Nelson J




Has Abstract


1989-12-01 00:00:00














  • Genetic association analyses of neuregulin 1 gene polymorphism with endopheontype for sociality of Korean autism spectrum disorders family.

    abstract::To determine the genetic association between qualitative and quantitative traits of autism spectrum disorder (ASD) and neuregulin 1 (NRG1)-a schizophrenia candidate gene-we examined six single nucleotide polymorphisms (SNPs) in NRG1 using a family-based association test (FBAT) in Korean families with ASD. rs35753505 a...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Yoo HJ,Woo RS,Cho SC,Kim BN,Kim JW,Shin MS,Park TW,Son JW,Chung US,Park S,Park M,Kim SA

    更新日期:2015-06-30 00:00:00

  • Possible confusion between primary hypersomnia and adult attention-deficit/hyperactivity disorder.

    abstract::We explored the possibility of diagnostic confusion between hypersomnias of central origin (narcolepsy and idiopathic hypersomnia, IH) and the adult form of attention-deficit/hyperactivity disorder (ADHD). We included 67 patients with narcolepsy, 7 with IH and 61 with ADHD. All patients completed the Epworth Sleepines...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Oosterloo M,Lammers GJ,Overeem S,de Noord I,Kooij JJ

    更新日期:2006-08-30 00:00:00

  • Distractibility in schizophrenia.

    abstract::This study examined the effects of neuroleptic medication on the allocation of attentional resources to distracting stimuli in patients with schizophrenia. Twenty-five patients were tested twice (medication-free and after medication stabilization) on the Identical Pairs versions of the Continuous Performance Test unde...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Bergman A,O'Brien J,Osgood G,Cornblatt B

    更新日期:1995-07-28 00:00:00

  • Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study.

    abstract::The aim of the study was to describe diagnostic stability and psychosocial outcomes of subjects with early-onset schizophrenia (EOS). All the subjects who had been hospitalized in the Department of Psychiatry of the First Affiliated Hospital of Kunming Medical University between January 2011 and July 2015 with the dia...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kang C,Zhou H,Yang J,Yang R,Sun N,Wang S,Yang C,Han D,Srihari VH

    更新日期:2019-01-01 00:00:00

  • Incompleteness and not just right experiences in the explanation of Obsessive-Compulsive Disorder.

    abstract::In the past decade, not just right experiences (NJRE) and incompleteness (INC) have attracted renewed interest as putative motivators of symptoms in obsessive-compulsive disorder (OCD), beyond harm avoidance (HA). This study examines, in 267 non-clinical undergraduates and 47 OCD patients, the differential contributio...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Belloch A,Fornés G,Carrasco A,López-Solá C,Alonso P,Menchón JM

    更新日期:2016-02-28 00:00:00

  • The cognitive attentional syndrome: examining relations with mood and anxiety symptoms and distinctiveness from psychological inflexibility in a clinical sample.

    abstract::Wells's (2009) metacognitive theory suggests that inflexible and recurrent styles of thinking in response to negative thoughts, feelings, and beliefs underlie mood and anxiety symptoms. Wells termed such styles of thinking as the cognitive attentional syndrome (CAS). Using a clinical sample (N=132) of patients with ei...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Fergus TA,Valentiner DP,McGrath PB,Gier-Lonsway S,Jencius S

    更新日期:2013-11-30 00:00:00

  • Asymmetrical distribution of beta-endorphin in cerebral hemispheres of suicides: preliminary data.

    abstract::The assessment of beta-endorphin levels in several symmetrical brain regions of seven suicides and seven sudden death controls reveals a decreased concentration in the left temporal cortex, the left frontal cortex, and the left caudate nucleus of suicides compared to controls. Moreover, the comparisons of beta-endorph...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Scarone S,Gambini O,Calabrese G,Sacerdote P,Bruni M,Carucci M,Panerai AE

    更新日期:1990-05-01 00:00:00

  • Rating scales in research: the case of negative symptoms.

    abstract::Two measures of negative schizophrenic symptoms, the Scale for the Assessment of Negative Symptoms and the withdrawal-retardation subscale of the Brief Psychiatric Rating Scale, are found to be redundant when used together. Studies incorporating redundant measures have numerous disadvantages. Using multiple scales inc...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Thiemann S,Csernansky JG,Berger PA

    更新日期:1987-01-01 00:00:00

  • A variable number of tandem repeats in the serotonin transporter gene does not affect the antidepressant response to fluvoxamine.

    abstract::A variable number of tandem repeats (VNTR) in the second intron of the serotonin transporter gene (STin2) has been studied in association with the susceptibility to affective disorders. Recently, it was reported that selective serotonin reuptake inhibitors were more effective in patients with major depressive disorder...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Ito K,Yoshida K,Sato K,Takahashi H,Kamata M,Higuchi H,Shimizu T,Itoh K,Inoue K,Tezuka T,Suzuki T,Ohkubo T,Sugawara K,Otani K

    更新日期:2002-08-30 00:00:00

  • Lifetime PTSD and quality of life among alcohol-dependent men: impact of childhood emotional abuse and dissociation.

    abstract::The aim of this study was to investigate the impact of lifetime posttraumatic stress disorder (PTSD), dissociation and a history of childhood trauma on quality of life (QoL) among men with alcohol dependency. A consecutive series of alcohol-dependent men (N=156) admitted to an inpatient treatment unit were screened us...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Evren C,Sar V,Dalbudak E,Cetin R,Durkaya M,Evren B,Celik S

    更新日期:2011-03-30 00:00:00

  • Behavioural studies of spatial working memory dysfunction in schizophrenia: a quantitative literature review.

    abstract::Cognitive impairments in schizophrenia have been recognized as a prominent feature of the illness. Research is now focusing on determining a relationship between neurocognitive impairments, and social and functional outcome. Despite a number of comprehensive reviews on neurocognitive measures and reports on spatial wo...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审


    authors: Piskulic D,Olver JS,Norman TR,Maruff P

    更新日期:2007-03-30 00:00:00

  • Epidemiological data on anorexia nervosa in Japan.

    abstract::An epidemiological survey on anorexia nervosa was performed in Japanese hospitals in 1985 and 1992 using a questionnaire. The reported number of patients with anorexia nervosa was 2391 from 732 institutions. From these data, the total number of anorexia nervosa patients treated in 1985 in Japanese hospitals was estima...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kuboki T,Nomura S,Ide M,Suematsu H,Araki S

    更新日期:1996-04-16 00:00:00

  • Decreased urinary peptide excretion in schizophrenic patients after neuroleptic treatment.

    abstract::Six schizophrenic patients had their urinary peptide levels measured before and after 5 weeks of treatment with neuroleptic medications. For two patients, levels were also measured after a reduction in the neuroleptic dose. Because of the heterogeneity of peptide peaks with the same bioactivity, the overall peptide le...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Reichelt KL,Teigland-Gjerstad B

    更新日期:1995-09-29 00:00:00

  • Course of adherence to medication and quality of life in people with schizophrenia.

    abstract::This study examined the relationship over time of adherence to anti-psychotic medication and quality of life in people with schizophrenia, taking into account effects of mediating variables. Data on on adherence, quality of life, attitude towards medication, side effects, symptom severity, and level of functioning at ...

    journal_title:Psychiatry research

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Puschner B,Angermeyer MC,Leese M,Thornicroft G,Schene A,Kikkert M,Burti L,Tansella M,Becker T

    更新日期:2009-02-28 00:00:00

  • Reinforcement learning deficits in people with schizophrenia persist after extended trials.

    abstract::Previous research suggests that people with schizophrenia have difficulty learning from positive feedback and when learning needs to occur rapidly. However, they seem to have relatively intact learning from negative feedback when learning occurs gradually. Participants are typically given a limited amount of acquisiti...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Cicero DC,Martin EA,Becker TM,Kerns JG

    更新日期:2014-12-30 00:00:00

  • Effects of mindfulness-based stress reduction on anxiety symptoms in young people: A systematic review and meta-analysis.

    abstract::In this study, we evaluated the efficacy of mindfulness-based stress reduction (MBSR) for young people with anxiety symptoms. We used many databases, including PubMed, PsycINFO, Web of Science, EMBASE, CINAHL and Cochrane Library (from inception to May 2019). We included randomized controlled trials (RCTs) comparing M...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审


    authors: Zhou X,Guo J,Lu G,Chen C,Xie Z,Liu J,Zhang C

    更新日期:2020-07-01 00:00:00

  • Outcomes, moderators, and mediators of empathic-emotion recognition training for complex conduct problems in childhood.

    abstract::Impairments in emotion recognition skills are a trans-diagnostic indicator of early mental health problems and may be responsive to intervention. We report on a randomized controlled trial of "Emotion-recognition-training" (ERT) versus treatment-as-usual (TAU) with N=195 mixed diagnostic children (mean age 10.52 years...

    journal_title:Psychiatry research

    pub_type: 杂志文章,随机对照试验


    authors: Dadds MR,Cauchi AJ,Wimalaweera S,Hawes DJ,Brennan J

    更新日期:2012-10-30 00:00:00

  • The role of premorbid personality and social cognition in suicidal behaviour in first-episode psychosis: A one-year follow-up study.

    abstract:BACKGROUND:High suicide attempt (SA) rates have been reported in first-episode psychosis (FEP) patients, particularly during the first year after the illness onset. Despite previous studies establishing several risk factors for suicidal behaviour in FEP, premorbid personality and social cognition have not been sufficie...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Canal-Rivero M,Lopez-Moriñigo JD,Barrigón ML,Perona-Garcelán S,Jimenez-Casado C,David AS,Obiols-Llandrich JE,Ruiz-Veguilla M

    更新日期:2017-10-01 00:00:00

  • Assessment of the frequency criterion for the diagnosis of non-suicidal self-injury disorder in female adolescents with conduct disorder.

    abstract::Recent studies suggest a higher threshold number of self-injuries during the past year than the one proposed in the DSM-5 criteria for non-suicidal self-injury disorder (NSSID). Therefore, we aimed to test a validity of the frequency criterion in girls with conduct disorder (CD) based on psychopathology and the level ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Szewczuk-Bogusławska M,Kaczmarek-Fojtar M,Moustafa AA,Mahlberg J,Frydecka D,Oleszkowicz A,Bąk O,Misiak B

    更新日期:2018-09-01 00:00:00

  • Applying computerized adaptive testing to the CES-D scale: a simulation study.

    abstract::In this paper we studied the appropriateness of developing an adaptive version of the Center of Epidemiological Studies-Depression (CES-D, Radloff, 1977) scale. Computerized Adaptive Testing (CAT) involves the computerized administration of a test in which each item is dynamically selected from a pool of items until a...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Smits N,Cuijpers P,van Straten A

    更新日期:2011-06-30 00:00:00

  • Urinary free cortisol levels in obsessive-compulsive disorder.

    abstract::Seventeen obsessive-compulsive disorder (OCD) patients and 25 normal control subjects submitted 24-hour urine samples for measurement of urinary free cortisol (UFC). Thirteen of the 17 OCD patients submitted a second 24-hour urine collection after a 10-week trial of either clomipramine (n = 6) or placebo (n = 7). At b...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章


    authors: Gehris TL,Kathol RG,Black DW,Noyes R Jr

    更新日期:1990-05-01 00:00:00

  • Tardive dyskinesia in schizophrenic patients: correlation with negative symptoms.

    abstract::The relationship between severity of tardive dyskinesia (TD) and the prominence of negative symptoms was assessed in 25 right-handed, medicated schizophrenic patients. TD was quantified using ultrasound detectors and frequency measurement techniques as well as with observer rating scales. Electromechanical studies rev...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Bartzokis G,Hill MA,Altshuler L,Cummings JL,Wirshing W,May PR

    更新日期:1989-05-01 00:00:00

  • Evidence of gray matter reduction and dysfunction in chromosome 22q11.2 deletion syndrome.

    abstract::Chromosome 22q11.2 deletion syndrome (22q11DS) is associated with cognitive deficits and morphometric brain abnormalities in childhood and a markedly elevated risk of schizophrenia in adolescence/early adulthood. Determining the relationship between neurocognition and neuroimaging findings would yield crucial informat...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Shashi V,Kwapil TR,Kaczorowski J,Berry MN,Santos CS,Howard TD,Goradia D,Prasad K,Vaibhav D,Rajarethinam R,Spence E,Keshavan MS

    更新日期:2010-01-30 00:00:00

  • The psychometrics of the Hospital Anxiety and Depression Scale supports a shorter -12 item- version.

    abstract::The diagnosis of patients suffering from both anxiety and depression is complex due to mixed effects of the two disorders. This complexity has hardened the task to find an adapted treatment for these patients. Consequently, several instruments, known as depression anxiety scales, have been developed and are now used i...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Maatoug R,Gorwood P

    更新日期:2019-04-01 00:00:00

  • Neuropsychological prognosis and clinical recovery.

    abstract::This report examines prognostic implications of neuropsychological deficit for clinical symptomatic improvement. Neuropsychological performance levels are related to the Brief Psychiatric Rating Scale thinking disturbance, paranoid disturbance, withdrawal/retardation, and anxiety/depression scales at hospital admissio...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Silverstein ML,Harrow M,Bryson GJ

    更新日期:1994-06-01 00:00:00

  • Using implicit association tests for the assessment of implicit personality self-concepts of extraversion and neuroticism in schizophrenia.

    abstract::There is evidence from research based on self-report personality measures that schizophrenia patients tend to be lower in extraversion and higher in neuroticism than healthy individuals. Self-report personality measures assess aspects of the explicit self-concept. The Implicit Association Test (IAT) has been developed...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Suslow T,Lindner C,Kugel H,Egloff B,Schmukle SC

    更新日期:2014-08-30 00:00:00

  • Relevance of treated cocaine users' retrospective memory of first cocaine use.

    abstract::Little is known regarding between-subject variability in the subjective effects of first cocaine use. This study retrospectively assesses the subjective effects of first cocaine use in 160 current treatment-seeking cocaine use disorder patients. Subjective effects of first cocaine use were evaluated with an ad-hoc que...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Karsinti E,Piani K,Zerdazi EH,Maskos U,Faure P,Romo L,Bellivier F,Brousse G,Lépine JP,Bloch V,Vorspan F

    更新日期:2018-06-01 00:00:00

  • Clinical course of psychiatric disorders in patients with cervical dystonia.

    abstract::We assessed the course of psychiatric disorders in 23 cervical dystonia patients by using the structured clinical interview for DSM-IV and different rating scales. Patients were studied on two occasions 5 years apart. There were no differences in psychiatric disorders and severity of psychiatric symptoms between the t...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Berardelli I,Ferrazzano G,Pasquini M,Biondi M,Berardelli A,Fabbrini G

    更新日期:2015-09-30 00:00:00

  • The relationship between personality disorder traits and reactive versus proactive motivation for aggression.

    abstract::There is a strong link between personality disorders (PDs) and aggression. This is reflected in high prevalence rates of PD diagnoses in forensic samples, and in several diagnostic criteria of PDs directly referring to elevated levels of aggression. Aggression can stem from two distinct types of motivation; reactive o...

    journal_title:Psychiatry research

    pub_type: 杂志文章,多中心研究


    authors: Lobbestael J,Cima M,Lemmens A

    更新日期:2015-09-30 00:00:00

  • High-dose naloxone affects task performance in normal subjects.

    abstract::Increasing intravenous doses of naloxone (0.3 mg/kg, 1 mg/kg, and 2 mg/kg) were administered to normal subjects. Naloxone at 2 mg/kg, but not at lower doses, impaired aspects of memory as measured by a verbal learning task which assessed the direct free recall and recognition of presented versus non-presented words of...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Cohen RM,Cohen MR,Weingartner H,Pickar D,Murphy DL

    更新日期:1983-02-01 00:00:00