Abstract：
:Earlier neuroimaging studies of working memory (WM) have demonstrated that dorsolateral prefrontal cortex (DLPFC) activity increases as maintenance and load demand increases. However, few studies have carefully disambiguated these two WM processes at the behavioral and physiological levels. The objective of the present functional resonance imaging (fMRI) study was to map within prefrontal cortex locales that are selectively load sensitive, delay sensitive, or both. We studied 18 right-handed normal subjects with fMRI at 3 Tesla during a block design version of the Sternberg task. WM load was manipulated by varying the memory set size (3, 5, or 8 letters). The effect of memory maintenance was examined by employing two time delays (1 s and 6 s) between the letter set and probe stimuli. The DLPFC was strongly activated in load manipulation, whereas activation as a function of delay was restricted to the left premotor regions and Broca's areas. Moreover, regions of prefrontal cortex on the right (BA 46) were found to be exclusively affected by load. These results suggest the possibility that top-down modulation of attention or cognitive control at encoding and/or decisionmaking may be mediated by these areas.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Altamura M,Elvevåg B,Blasi G,Bertolino A,Callicott JH,Weinberger DR,Mattay VS,Goldberg TEdoi
10.1016/j.pscychresns.2006.08.002subject
Has Abstractpub_date
2007-02-28 00:00:00pages
103-14issue
2eissn
0165-1781issn
1872-7123pii
S0925-4927(06)00127-2journal_volume
154pub_type
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