Abstract:
:To explore changes in immune cell status with changes in the hypothalamic-pituitary (HP) axis in 20 patients with major depression as compared with 20 age-, sex-, and race-matched control subjects, we examined peripheral blood mononuclear cells (PBMC) for total T-cells (T3), total B-cells (B1), two T-cell subsets (T4 and T8), and natural killer cells (NKH1), and we measured the plasma level of cortisol, adrenocorticotropic hormone (ACTH), growth hormone (GH), and prolactin (PRL). The ratio of T4/T8 was increased in the patients. Within the group of control subjects only, increasing age correlated significantly with decreasing plasma PRL. Within the group of patients only, GH positively correlated significantly with T8 and NKH1, as did PRL with NKH1. No between-groups difference was found for T3, B1, T4, T8, NKH1, cortisol, ACTH, GH, or PRL.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Darko DF,Gillin JC,Risch SC,Bulloch K,Golshan S,Tasevska Z,Hamburger RNdoi
10.1016/0165-1781(88)90048-0subject
Has Abstractpub_date
1988-08-01 00:00:00pages
173-9issue
2eissn
0165-1781issn
1872-7123pii
0165-1781(88)90048-0journal_volume
25pub_type
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