Abstract:
:This study detected the differences in gene expression and DNA methylation of CpG sites in CXCL1 gene and further investigated their associations with clinical symptoms in deficit schizophrenia (DS) and non-deficit schizophrenia (NDS). Pyrosequencing and RT-qPCR were separately used to determine DNA methylation and mRNA expression of CXCL1 gene. Both DNA methylation and expression were significantly different among DS, NDS and healthy control (HC) groups. Correlation analysis revealed that CXCL1 gene expression was associated with the negative syndrome in NDS patients, while no association in DS patients was observed. All together, these results suggest that DS may be a specific subgroup of schizophrenia with the characteristic abnormality of peripheral CXCL1 DNA methylation and gene expression.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Zhou C,Chen J,Tang X,Feng X,Yu M,Sha W,Wang X,Zhang X,Yi H,Zhang Xdoi
10.1016/j.psychres.2018.06.067subject
Has Abstractpub_date
2018-10-01 00:00:00pages
82-86eissn
0165-1781issn
1872-7123pii
S0165-1781(18)30511-0journal_volume
268pub_type
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