Abstract：
:The object of this study was to determine the reproducibility of the measurement of plasma catecholamine metabolites in normal control subjects and to assess the influence of factors such as time of day, diet, activity, blood pressure, and mood on the variance of these measures. Plasma free homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and vanillylmandelic acid (VMA) were simultaneously measured by high performance liquid chromatography with electrochemical detection. Samples were collected from 15 doctors and nurses at 8 a.m. and at noon on 2 separate days. After the fasting 8 a.m. sample, the subjects ate a regular hospital breakfast. Activity in their usual tasks on an inpatient psychiatric unit was monitored electronically by an activity meter. Levels of each metabolite were not significantly different between days at the respective assay times and were highly correlated for individuals. MHPG showed a significant increase from morning to noon, while HVA showed a significant decrease. Activity, dietary intake of tyrosine and tyramine, blood pressure, pulse, scores on the Profile of Mood States, age, and sex were not related to plasma levels. The results demonstrate that measures of dopamine and norepinephrine metabolites have significant reliability in normal subjects in a setting used for research studies with psychiatric patients.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Baker NJ,Adler LE,Waldo M,Gerhardt G,Drebing C,Cox B,Berry S,Phillips W,Freedman Rdoi
10.1016/0165-1781(88)90001-7subject
Has Abstractpub_date
1988-02-01 00:00:00pages
119-30issue
2eissn
0165-1781issn
1872-7123pii
0165-1781(88)90001-7journal_volume
23pub_type
杂志文章abstract：:Both psychiatric disorders and psychiatric drug treatments produce changes of psychomotor performance which can disturb and/or interfere with the ability to drive safely. We studied the influence of current psychiatric drug treatments on psychomotor functions and on driving performance of 77 consecutive psychiatric ou...
journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(93)90003-y
更新日期：1993-01-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,meta分析,评审
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abstract：:Predicting the outcome of antidepressant treatment by pre-treatment features would be of great usefulness for clinicians as up to 50% of major depressives may not have a satisfactory response in spite of adequate trials of antidepressant drugs. In the present article we compared a linear multivariate model of predicto...
journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
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pub_type： 临床试验,杂志文章
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journal_title：Psychiatry research
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pub_type： 临床试验,杂志文章
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更新日期：1990-08-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
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doi：10.1016/j.psychres.2017.08.007
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journal_title：Psychiatry research
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更新日期：2018-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2013-01-30 00:00:00
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pub_type： 杂志文章,评审
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pub_type： 杂志文章
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pub_type： 杂志文章
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