Effects of electroconvulsive shock on neuro-immune responses: Does neuro-damage occur?


:Electroconvulsive therapy (ECT) is one of the most effective treatments for treatment-resistant depression. However, this treatment may produce memory impairment. The mechanisms of the cognitive adverse effects are not known. Neuroimmune response is related to the cognitive deficits. By reviewing the available animal literature, we examined the glia activation, inflammatory cytokines, neuron oxidative stress responses, and neural morphological changes following electroconvulsive shock (ECS) treatment. The studies showed that ECS activates microglia, upregulates neuro-inflammatory cytokines, and increases oxidative stress responses. But these effects are rapid and may be transient. They normalize as ECS treatment continues, suggesting endogenous neuroprotection may be mobilized. The transient changes are well in line with the clinical observations that ECT usually does not cause significant long-lasting retrograde amnesia. The longitudinal studies will be particularly important to explore the dynamic changes of neuroplasticity following ECT (Jonckheere et al., 2018). Investigating the neuroplasticity changes in animals that suffered chronic stress may also be crucial to giving support to the translation of preclinical research.


Psychiatry Res


Psychiatry research


An X,Shi X




Has Abstract


2020-10-01 00:00:00












  • Thinking or doing? An examination of well-established suicide correlates within the ideation-to-action framework.

    abstract::Limited research has examined differences in well-established suicide correlates between individuals with various histories of suicidality within the ideation to action framework. We hypothesized that individuals without a history of elevated suicidality would exhibit lowest levels of suicide correlates (perceived bur...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Khazem LR,Anestis MD

    更新日期:2016-11-30 00:00:00

  • Deficits in probabilistic classification learning and liability for schizophrenia.

    abstract::Patients with schizophrenia show deficits in skill learning. We tested the hypothesis that impaired skill learning is associated with liability for schizophrenia by determining if it is present in non-affected siblings of patients. This study examined cognitive skill learning in adolescent siblings of patients with ch...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Wagshal D,Knowlton BJ,Cohen JR,Poldrack RA,Bookheimer SY,Bilder RM,Fernandez VG,Asarnow RF

    更新日期:2012-12-30 00:00:00

  • Decreased serum levels of adiponectin in adult attention deficit hyperactivity disorder.

    abstract::The main aim of this study was to investigate serum levels of adiponectin in adult patients with attention deficit hyperactivity disorder (ADHD). The second objective was to examine the effects of rare missense mutations in T-cadherin, an adiponectin receptor encoded by the ADHD candidate gene CDH13, on serum adiponec...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Mavroconstanti T,Halmøy A,Haavik J

    更新日期:2014-04-30 00:00:00

  • Plasma dopamine beta-hydroxylase activity in psychotic and non-psychotic post-traumatic stress disorder.

    abstract::Recognition and treatment of comorbid chronic psychotic symptoms in post-traumatic stress disorder (PTSD) has become of increasing clinical interest. Altered dopamine beta-hydroxylase (DBH) activity has been reported in mood disorders. Plasma DBH is reduced in major depression with psychosis and elevated in bipolar di...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Hamner MB,Gold PB

    更新日期:1998-02-27 00:00:00

  • Connections that moderate risk of non-suicidal self-injury among transgender and gender non-conforming youth.

    abstract::We examined associations between social connections and non-suicidal self-injury (NSSI) among transgender/gender non-conforming (TGNC) youth. Data came from the 2016 Minnesota Student Survey (N = 2168). Logistic regression analyses determined connectedness factors associated with any past-year NSSI and repetitive NSSI...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Taliaferro LA,McMorris BJ,Eisenberg ME

    更新日期:2018-10-01 00:00:00

  • Specific sensitivity of patients with panic attacks to carbon dioxide inhalation.

    abstract::One inhalation of 35% CO2 in oxygen was administered to 36 patients with anxiety disorders and 14 healthy controls. Eighteen patients had a diagnosis of panic disorder (PD) and 18 of obsessive-compulsive disorder (OCD). As a placebo control for CO2, compressed air was administered in a double-blind design. Immediately...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章


    authors: Griez E,de Loof C,Pols H,Zandbergen J,Lousberg H

    更新日期:1990-02-01 00:00:00

  • Facial emotion recognition in adolescents with nonsuicidal self-injury.

    abstract::Adolescents with nonsuicidal self-injury (NSSI) have been described as having considerable impairment in social interactions, and social difficulties are often a trigger for NSSI. However, little is known about how adolescents with NSSI disorder process facial expressions of emotion. We investigated the recognition of...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: In-Albon T,Ruf C,Schmid M

    更新日期:2015-08-30 00:00:00

  • Set-shifting abilities, mood and loss of control over eating in binge eating disorder: An experimental study.

    abstract::Executive functions play an important role in problem-solving and self-control. Set-shifting is an aspect of executive functioning and represents cognitive flexibility. The inability to control eating in Binge Eating Disorder (BED) may imply deficits in set-shifting which could be exacerbated by negative mood and depr...

    journal_title:Psychiatry research

    pub_type: 杂志文章,多中心研究


    authors: Dingemans AE,Visser H,Paul L,van Furth EF

    更新日期:2015-12-15 00:00:00

  • Differentiating adolescents at clinical high risk for psychosis from psychotic and non-psychotic patients with the Rorschach.

    abstract::This study was designed to assess cognitive functioning in a clinical sample of adolescents with heterogeneous psychiatric diagnoses, with a specific focus on patients at clinical high risk (CHR) for psychosis. The sample comprised 22 patients identified at CHR for psychosis, 67 psychotic and 187 non-psychotic, non-CH...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Ilonen T,Heinimaa M,Korkeila J,Svirskis T,Salokangas RK

    更新日期:2010-09-30 00:00:00

  • Perceptual grouping in disorganized schizophrenia.

    abstract::This study evaluated visual perceptual grouping in schizophrenia to test the hypothesis that the disorganization syndrome in schizophrenia is related to a deficit in cognitive coordination. Perceptual grouping was examined with three psychophysically well-controlled tasks in patients with disorganized schizophrenia (n...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Uhlhaas PJ,Phillips WA,Mitchell G,Silverstein SM

    更新日期:2006-12-07 00:00:00

  • Factors influencing the severity of behavioral phenotype in autism spectrum disorders: Implications for research.

    abstract::The phenotypic heterogeneity of Autism Spectrum Disorders (ASD) presents particular research challenges in the assessment of symptom severity, while the standardized Autism Diagnostic Observation Schedule (ADOS) scores present a severity metric, namely calibrated severity scores (CSS) that are relatively impervious to...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Zou M,Sun C,Wang J,Kang J,Xu Z,Ma Y,Chen L,Zhang X,Xia W,Wu L

    更新日期:2018-03-01 00:00:00

  • Examination of trait impulsivity on the response to a brief mindfulness intervention among college student drinkers.

    abstract::Mindfulness-based strategies show promise for targeting the construct of impulsivity and associated variables among problematic alcohol users. This study examined the moderating role of intervention (mindfulness vs relaxation vs control) on trait impulsivity and three outcomes examined post-intervention (negative affe...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Vinci C,Peltier M,Waldo K,Kinsaul J,Shah S,Coffey SF,Copeland AL

    更新日期:2016-08-30 00:00:00

  • The volumes of the fornix in schizophrenia and affective disorders: a post-mortem study.

    abstract::Structural and functional pathology of limbic structures including the hippocampus are frequently replicated in schizophrenia. Although the fornix is the main afferent system of the hippocampus to the septal nuclei and the hypothalamus (especially the mammillary bodies), relatively few studies have investigated struct...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Brisch R,Bernstein HG,Stauch R,Dobrowolny H,Krell D,Truebner K,Meyer-Lotz G,Bielau H,Steiner J,Kropf S,Gos T,Danos P,Bogerts B

    更新日期:2008-12-30 00:00:00

  • Folate and MMA predict cognitive impairment in elderly stroke survivors: A cross sectional study.

    abstract::Elderly stroke survivors are at risk of malnutrition and long-term cognitive impairment. Vitamin B-related metabolites, folate and methylmalonic acid, have been implicated in cognitive function. We conducted a study exploring the relationship between blood folate, methylmalonic acid and post-stroke cognitive impairmen...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Pascoe MC,Linden T

    更新日期:2016-09-30 00:00:00

  • Neuroleptic-induced defecation in rats as a model for neuroleptic dysphoria.

    abstract::Two groups of 32 rats were challenged in a well-habituated environment with haloperidol (0.5 mg/kg), haloperidol (0.1 mg/kg), domperidone (0.1 mg/kg), or saline to study the effect of these drugs on defecation--an index of emotionality--and voluntary movements in the 2 hours after the injection. The haloperidol-treate...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Sachdev P,Loneragan C,Westbrook F

    更新日期:1993-04-01 00:00:00

  • Investigation of shared genetic effects for psychotic and obsessive symptoms in young adult twins.

    abstract::Genetic and environmental architecture of psychotic and obsessive symptoms are not completely elucidated. This study estimated for these symptoms (i) the genetic and environmental components, (ii) the within-individual association, and (iii) the extent to which this association originates from common genetic and envir...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Fagnani C,Bellani M,Tansella M,Balestrieri M,Toccaceli V,Patriarca V,Stazi MA,Brambilla P

    更新日期:2011-07-30 00:00:00

  • Neurobiological effects of lumbar puncture stress in psychiatric patients and healthy volunteers.

    abstract::Several existing laboratory-based stress paradigms have significant shortcomings for assessing neurobiological correlates of stress in healthy volunteers and severely ill psychiatric patients. We have examined neuroendocrine effects of stress associated with the lumbar puncture (LP) procedure in drug-free depressed an...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Breier A,Wolkowitz OM,Doran AR,Bellar S,Pickar D

    更新日期:1988-08-01 00:00:00

  • Evidence for reduced somatosensory lateralisation and focalisation in schizophrenia.

    abstract::Neuroimaging studies indicate diminished lateralisation of cerebral activity during motor tasks and language processing in schizophrenia. Some evidence also indicates that decreased lateralisation is accompanied by more diffuse intra-hemispheric activation, suggesting that diminished lateralisation might be part of a ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: White TP,Francis ST,Joseph V,O'Regan E,Head KE,Liddle PF

    更新日期:2009-10-30 00:00:00

  • Anxiety, depression, impulsivity and substance misuse in violent and non-violent adolescent boys in detention in China.

    abstract::The present investigation aims to identify the factors which differentiate violent from non-violent juvenile offenders, with a particular emphasis on the association between internalizing psychiatric morbidity (i.e. anxiety and depression), impulsivity, substance misuse, and violence. A total of 323 incarcerated male ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Zhou J,Witt K,Zhang Y,Chen C,Qiu C,Cao L,Wang X

    更新日期:2014-05-30 00:00:00

  • Heart rate and respiratory response to doxapram in patients with panic disorder.

    abstract::Panic disorder (PD) is characterized by anticipatory anxiety and panic, both causing physiological arousal. We investigated the differential responses between anticipatory anxiety and panic in PD and healthy controls (HC). Subjects (15 PD and 30 HC) received an injection of a respiratory stimulant, doxapram, with a hi...

    journal_title:Psychiatry research

    pub_type: 杂志文章,随机对照试验


    authors: Martinez JM,Garakani A,Aaronson CJ,Gorman JM

    更新日期:2015-05-30 00:00:00

  • Catechol-O-methyltransferase Val158Met polymorphism affects therapeutic response to mood stabilizer in symptomatic manic patients.

    abstract::Catechol-O-methyltransferase (COMT) is a candidate gene for the pathogenesis of some psychiatric disorders. The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical aspects of bipolar disorder including symptomatology and therapeutic response. This study comprised 144 unrela...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Lee HY,Kim YK

    更新日期:2010-01-30 00:00:00

  • Association between schizophrenia and Toxoplasma gondii infection in Algeria.

    abstract::Toxoplasmosis has been previously associated with an increased risk of having schizophrenia in several epidemiological studies. The aim of this prospective study was to examine for the first time a possible association between positive serology to Toxoplasma gondii (T. gondii) and schizophrenia in the Algerian populat...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kezai AM,Lecoeur C,Hot D,Bounechada M,Alouani ML,Marion S

    更新日期:2020-09-01 00:00:00

  • Testing a new interpersonal model of disordered eating between Australian and East-Asian women: The relationships between theory of mind, maladaptive schemas, and appearance-based rejection sensitivity.

    abstract::The current study tested a new interpersonal model of disordered eating behaviours, whereby maladaptive schemas and theory of mind decoding (ToM-decoding) were related with disordered eating attitudes (body dissatisfaction) and behaviours (binging/purging and food restriction) through the mediating variable appearance...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kimball H,Fuller-Tyszkiewicz M,De Paoli T,McKinlay A,Krug I

    更新日期:2019-05-01 00:00:00

  • The association between alexithymia as assessed by the 20-item Toronto Alexithymia Scale and depression: A meta-analysis.

    abstract::Patients with depression exhibit high rates of alexithymia, representing a major public health concern. We sought to examine relationships between depression severity and alexithymia as assessed by the Toronto Alexithymia Scale (TAS-20) and the TAS-20 subscales of difficulty identifying feelings (DIF), difficulty desc...

    journal_title:Psychiatry research

    pub_type: 杂志文章,meta分析,评审


    authors: Li S,Zhang B,Guo Y,Zhang J

    更新日期:2015-05-30 00:00:00

  • Associations between neuropsychiatric and health status outcomes in individuals with probable mTBI.

    abstract::Mild traumatic brain injury (mTBI) is a common occurrence, and may impact distal outcomes in a subgroup of individuals. Improved characterization of health outcomes and identification of factors associated with poor outcomes is needed to better understand the impact of mTBI, particularly in those with co-occurring pos...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Bomyea J,Flashman LA,Zafonte R,Andaluz N,Coimbra R,George MS,Grant GA,Marx CE,McAllister TW,Shutter L,Lang AJ,Stein MB

    更新日期:2019-02-01 00:00:00

  • Adverse life events and the onset of anxiety disorders.

    abstract::This study tested the hypothesis that adverse events are associated with increased risk of onset of anxiety disorders. Data from Waves 1 (N = 43,093; 2001-2002) and 2 (N = 34,653; 2004-2005) of the National Epidemiological Survey on Alcohol and Related Conditions (NESARC) were used to assess whether adverse events at ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Miloyan B,Joseph Bienvenu O,Brilot B,Eaton WW

    更新日期:2018-01-01 00:00:00

  • Investigation of automatic avoidance in displaced individuals with chronic Posttraumatic Stress Disorder (PTSD).

    abstract::Avoidance of trauma-related stimuli is a key feature of Posttraumatic Stress Disorder (PTSD). However, avoidance has almost exclusively been investigated with explicit measures targeting more strategic aspects of behavior. The aim of the present study was to examine automatic avoidance in older individuals displaced a...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Wittekind CE,Behmer F,Muhtz C,Fritzsche A,Moritz S,Jelinek L

    更新日期:2015-08-30 00:00:00

  • The use of narrative sampling in the assessment of social cognition: the Narrative of Emotions Task (NET).

    abstract::Social cognitive deficits in schizophrenia are well documented and related to functional outcome. Current social cognition measures are often not psychometrically validated, too heterogeneous for standardization, and focus principally on one domain of social cognition rather than the simultaneous activation of multipl...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Buck B,Ludwig K,Meyer PS,Penn DL

    更新日期:2014-07-30 00:00:00

  • Posttraumatic stress disorder may be associated with impaired fear inhibition: relation to symptom severity.

    abstract::One of the central problems in posttraumatic stress disorder (PTSD) is the inability to suppress fear even under safe conditions. The neural underpinnings of fear are clinically relevant but poorly understood. This study assessed fear potentiation and fear inhibition using fear-potentiated startle in a conditional dis...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Jovanovic T,Norrholm SD,Fennell JE,Keyes M,Fiallos AM,Myers KM,Davis M,Duncan EJ

    更新日期:2009-05-15 00:00:00

  • Hippocampal activation during processing of previously seen visual stimulus pairs.

    abstract::Activity in the hippocampus is modulated by novelty detection, and by the processing of conjunctions between two stimuli. We investigated whether the hippocampus is activated by discrimination of stimulus-stimulus relationships in novel versus familiar pairs of visual stimuli in 15 healthy subjects using functional ma...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Ongür D,Zalesak M,Weiss AP,Ditman T,Titone D,Heckers S

    更新日期:2005-08-30 00:00:00