Abstract:
:To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Volkow ND,Hitzemann R,Wolf AP,Logan J,Fowler JS,Christman D,Dewey SL,Schlyer D,Burr G,Vitkun Sdoi
10.1016/0925-4927(90)90007-ssubject
Has Abstract,Author List Incompletepub_date
1990-04-01 00:00:00pages
39-48issue
1eissn
0165-1781issn
1872-7123pii
S0165-1781(06)80006-5journal_volume
35pub_type
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