Acute effects of ethanol on regional brain glucose metabolism and transport.

Abstract:

:To evaluate the effects of ethanol in the human brain, we tested six normal subjects and six alcoholics using positron emission tomography and 2-deoxy-2-[18F]-fluoro-D-glucose (FDG) under baseline conditions and 24 hours later after ethanol administration (1 g/kg). Ethanol inhibited cortical and cerebellar glucose metabolism with relative sparing of the basal ganglia and corpus callosum. This inhibition was more pronounced in the alcoholics than in the controls. Measurement of the constants for glucose transport and utilization showed that decreased glucose metabolism was due to a reduction in glucose phosphorylation and not to a change of glucose transport into the tissue. The pattern of regional metabolic inhibition by alcohol paralleled the distribution of benzodiazepine receptors in the human brain.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Volkow ND,Hitzemann R,Wolf AP,Logan J,Fowler JS,Christman D,Dewey SL,Schlyer D,Burr G,Vitkun S

doi

10.1016/0925-4927(90)90007-s

subject

Has Abstract,Author List Incomplete

pub_date

1990-04-01 00:00:00

pages

39-48

issue

1

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(06)80006-5

journal_volume

35

pub_type

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