Abstract：
:We aim to replicate AKT1 gene variants studies using Malaysian samples. Seven AKT1 single nucleotide polymorphisms (SNPs) were studied in 417 patients and 429 controls. Haplotype showed significant association (p=0.036) with schizophrenia, especially in Malays and Indians. Meta-analysis of rs2494732 showed significant association worldwide (p=0.018) and in Asians (p=0.023).
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Loh HC,Chow TJ,Tang PY,Yong HSdoi
10.1016/j.psychres.2013.05.017subject
Has Abstractpub_date
2013-10-30 00:00:00pages
732-3issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(13)00276-Xjournal_volume
209pub_type
杂志文章,meta分析abstract：:We present psychometric properties and normative data by gender and educational level in scales related to schizotypy and affective disorders in a large population-based adult sample. As part of the 31-year follow-up survey of the Northern Finland 1966 Birth Cohort; Bipolar II scale (BIP2), Hypomanic Personality Scale...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.07.022
更新日期：2010-07-30 00:00:00
abstract：:The aim of this study is to investigate whether mismatch negativity (MMN) is associated with functional status or is a state-independent trait for schizophrenia. We assessed MMN in 26 patients with schizophrenia, 20 healthy subjects with high genetic loading, and 48 healthy controls. Repeated measures analysis of vari...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2014.02.012
更新日期：2014-04-30 00:00:00
abstract：:Social cognition refers to a set of cognitive abilities that allow us to perceive and interpret social stimuli. Social cognition is affected in schizophrenia and impairments have also been documented in unaffected relatives, suggesting that social cognition may be related to a genetic vulnerability to the disease. Thi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.07.055
更新日期：2014-12-15 00:00:00
abstract：:Timing is an essential function for the survival of many living organisms. Despite its significance, it is relatively under-researched, particularly in schizophrenia. We examined neurophysiological, neuropathological, imaging and genetic studies of both healthy subjects and subjects suffering from schizophrenia in rel...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2014.07.048
更新日期：2014-12-30 00:00:00
abstract：:Considerable evidence suggests that there is a relationship between pathologic aggressive behavior and low cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in both humans and non-human primates. The purpose of this investigation is to examine the relationship bet...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(99)00022-0
更新日期：1999-04-19 00:00:00
abstract：:We performed spectral analysis on the QRS complex of the electrocardiogram obtained using standard limb leads, sampled at 500 Hz with 12 bit precision in 20 normal subjects and 15 patients with panic disorder. We divided the frequency range of the QRS into two bands based on spectral patterns before and after the post...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(96)02998-8
更新日期：1997-02-07 00:00:00
abstract：:Executive dysfunctions have been consistently demonstrated in patients with schizophrenia. This study aimed to investigate deficits in specific executive functioning components, namely working memory and inhibition, in schizophrenia. In study 1, a set of neurocognitive function tests was administered to 41 patients wi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.07.014
更新日期：2010-10-30 00:00:00
abstract：:This report examines prognostic implications of neuropsychological deficit for clinical symptomatic improvement. Neuropsychological performance levels are related to the Brief Psychiatric Rating Scale thinking disturbance, paranoid disturbance, withdrawal/retardation, and anxiety/depression scales at hospital admissio...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(94)90072-8
更新日期：1994-06-01 00:00:00
abstract：:Schizophrenia patients show abnormalities in the processing of facial emotion. The amygdala is a central part of a brain network that is involved in the perception of facial emotions. Previous functional neuroimaging studies on the perception of facial emotion in schizophrenia have focused almost exclusively on contro...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2010.03.005
更新日期：2010-06-30 00:00:00
abstract：:Panic disorder is associated with an elevated risk of cardiovascular disease and sudden death. Individuals with panic disorder have been shown to have reduced variability in heart rate and increased variability in the QT interval on electrocardiogram (ECG), patterns predictive of sudden cardiac death in certain forms ...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/j.psychres.2003.10.002
更新日期：2004-01-30 00:00:00
abstract：:Increasing evidence implicates altered dopamine function in major affective illness. In the present study, growth hormone responses to the dopamine agonist apomorphine were not different for 14 male depressed patients and 16 healthy male volunteers. Baseline and post-apomorphine prolactin levels were lower for the dep...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(84)90113-6
更新日期：1984-09-01 00:00:00
abstract：:Dewan asserted 20 years ago that a bedside light could shorten and regularize the menstrual cycle among women with long and irregular menstrual patterns. To replicate this, seven volunteers slept with a 100-watt bulb by the bedside from days 13-17 of their menstrual cycles, while nine controls similarly used a dim red...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(90)90067-f
更新日期：1990-08-01 00:00:00
abstract：:Patients with borderline personality disorder (BPD) suffer from various impairments in emotional functioning such as affective instability, inappropriate anger and unstable relationships. These deficits may influence two fundamental motivational systems, the behavioral inhibition system (BIS) and behavioral activation...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.04.027
更新日期：2014-08-15 00:00:00
abstract：:Structural neuroimaging studies of the amygdala and hippocampus in bipolar disorder have been largely inconsistent. This may be due in part to differences in the proportion of subjects taking lithium or experiencing an acute mood state, as both factors have recently been shown to influence gray matter structure. To av...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.08.002
更新日期：2013-03-30 00:00:00
abstract：:Despite findings indicating that anxiety disorders are more likely to co-occur with each other than occur in isolation, little research has explored precise areas of overlap and differentiation among comorbid pairs of anxiety disorders. Furthermore, many studies comparing phenomena across anxiety disorders define comp...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.11.017
更新日期：2015-01-30 00:00:00
abstract：:Abnormalities in the neurohypophyseal system have been reported in depression. This study aimed to investigate serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment on these levels. Serum oxytocin levels were measured before and after treatment with antidepressant dru...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/j.psychres.2008.06.034
更新日期：2009-10-30 00:00:00
abstract：:Numerous studies have documented a significant association between symptom severity and cognitive functioning in bipolar disorder (BD). These findings advanced speculations about a potential link between the physiological stress associated with illness severity and cognitive dysfunction. To explore this hypothesis, th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.07.059
更新日期：2014-12-30 00:00:00
abstract：:The Unified Biosocial Theory of Personality developed by Cloninger has been applied in different cultures. Distribution by age and sex of the Temperament and Character Inventory (TCI) dimensions were assessed cross-culturally for samples in Spain and the USA. Three non-clinical samples were included: i) 404 participan...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.07.021
更新日期：2011-04-30 00:00:00
abstract：:Electroconvulsive therapy (ECT) is one of the most effective treatments for treatment-resistant depression. However, this treatment may produce memory impairment. The mechanisms of the cognitive adverse effects are not known. Neuroimmune response is related to the cognitive deficits. By reviewing the available animal ...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2020.113289
更新日期：2020-10-01 00:00:00
abstract：:Lactate is a product of glycolysis by astrocytes and can be generated as a primary metabolic energy source by neurons. Lactate plays multifunctional role in human brain energy metabolism and cognitive function. However, no direct evidence demonstrated the link between lactate and cognition in normal condition. In the ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.05.017
更新日期：2017-09-01 00:00:00
abstract：:Our study aimed to evaluate the presence of antibodies related to gluten intolerance in patients with mood disorders. A total of 60 patients with a diagnosis of bipolar disorder or depressive disorder were recruited. Fourty-eight subjects randomly selected among unrelated family members were included as controls. Celi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.12.008
更新日期：2018-02-01 00:00:00
abstract：:High affinity 3H-paroxetine binding was studied in human frontal cortex and hippocampus obtained from normal controls and alcoholics. On the basis of Scatchard analyses, a significant decrease in the maximal number of binding sites (Bmax) was found in the hippocampus of alcoholics (n = 8) as compared with that of cont...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90019-l
更新日期：1991-09-01 00:00:00
abstract：:Obsessive-compulsive disorder (OCD) has been linked to a dysfunction of brain corticostriatal networks, although functional imaging studies of OCD rarely apply network-sensitive analysis methods. In this study, we compared a univariate and a multivariate analysis of PET data in OCD patients and healthy subjects; the l...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2006.03.002
更新日期：2006-10-30 00:00:00
abstract：:Few studies have examined whether there is a relationship between social anhedonia and prediction of future events and the role of beliefs about pleasure and emotional experience. In this study, 513 college students were recruited to complete a set of self-reported questionnaires, including the Revised Social Anhedoni...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.03.070
更新日期：2018-06-01 00:00:00
abstract：:Cognitive impairments in schizophrenia have been recognized as a prominent feature of the illness. Research is now focusing on determining a relationship between neurocognitive impairments, and social and functional outcome. Despite a number of comprehensive reviews on neurocognitive measures and reports on spatial wo...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2006.03.018
更新日期：2007-03-30 00:00:00
abstract：:Reliable quantitative ratings of chronic medical illness burden have proved to be difficult in geropsychiatric practice and research. Thus, the purpose of the study was to demonstrate the feasibility and reliability of a modified version of the Cumulative Illness Rating Scale (CIRS; Linn et al., 1968) in providing qua...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(92)90005-n
更新日期：1992-03-01 00:00:00
abstract：:Emotion has been conceptualized as a dimensional construct, while the number of dimensions - two or three - has been debated. Research has consistently identified two dimensions - valence and arousal - though ample evidence exists that three dimensions are necessary to describe emotion. One proposed third dimension, i...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2013.11.007
更新日期：2014-02-28 00:00:00
abstract：:Treatment of bipolar disorder often results in patients taking several drugs in an attempt to alleviate residual depressive symptoms, which can lead to an accumulation of side effects. New treatments for bipolar depression that do not increase the side effect burden are needed. One nonpharmacological treatment with fe...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2012.01.015
更新日期：2012-03-30 00:00:00
abstract：:Comparative studies are needed to determine whether the cognitive impairments found in various psychiatric disorders are specific to those disorders, or are a more universal consequence of mental illness. This study compares the patterns of cognitive dysfunction in two conditions characterized by working memory dysfun...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.04.001
更新日期：2008-05-30 00:00:00
abstract：:Impairments in source monitoring have been widely reported in schizophrenia, with patients typically misattributing self-generated items to external sources. Some studies have reported that patients with more severe positive symptoms (notably hallucinations) exhibit a greater impairment on these tasks, although findin...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.02.018
更新日期：2008-06-30 00:00:00
