Abstract：
:Considerable evidence suggests that there is a relationship between pathologic aggressive behavior and low cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in both humans and non-human primates. The purpose of this investigation is to examine the relationship between CSF concentrations of human newborn 5-HIAA and subsequent aggressive behavior observed at 30 months of age. Leftover portions of culture negative CSF drawn from febrile infants (age, birth to 3 months) were assayed for 5-HIAA. Family environment and child behavior were assessed at 30 months by parent report. Subjects with 5-HIAA levels below the median of the distribution had higher externalizing behavior scores at 30 months than did subjects whose 5-HIAA levels fell above the median (P = 0.02). While it is likely that serotonin mediates one component of genetic liability to antisocial outcome, the magnitude of that component may be less than what has been inferred from previously published reports.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Clarke RA,Murphy DL,Constantino JNdoi
10.1016/s0165-1781(99)00022-0subject
Has Abstractpub_date
1999-04-19 00:00:00pages
29-40issue
1eissn
0165-1781issn
1872-7123pii
S0165-1781(99)00022-0journal_volume
86pub_type
杂志文章abstract：:Major depressive disorder is associated with lower medial prefrontal cortex volumes. The role that gender might play in moderating this relationship and what particular medial prefrontal cortex subregion(s) might be implicated is unclear. Magnetic resonance imaging was used to assess dorsal, ventral, and anterior cing...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2015.06.005
更新日期：2015-08-30 00:00:00
abstract：:Delayed treatment seeking for people experiencing symptoms of mental illness is common despite available mental healthcare. Poor outcomes are associated with untreated mental illness and caregivers may eventually need to seek help on the service user's behalf. More attention has recently focused on the role of stigma ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.05.044
更新日期：2015-08-30 00:00:00
abstract：:In humans, there is an endogenous, near 24-h (i.e., circadian) variation in mood with the best mood occurring during the circadian day and the worst mood occurring during the circadian night. Only positive affect, and not negative affect, has been shown to contribute to this circadian rhythm. We discovered a sharp cir...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113337
更新日期：2020-11-01 00:00:00
abstract：:Past studies suggest that phenylthiocarbamide (PTC) taste status is related to vulnerability to depression, such that those sensitive to PTC are more vulnerable. We questioned this, reasoning that those insensitive to PTC may be more vulnerable (because they may have lower hedonic tone and higher risk for alcohol abus...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2003.12.020
更新日期：2004-04-15 00:00:00
abstract：:Two different initial dosing regimens with clomipramine (CMI) were used to compare early response indicators and dose strategies. Thirty-two inpatients with major depressive disorder were randomized in a double-blind protocol. The pulse-loading group received 150 and 200 mg of CMI on 2 consecutive evenings and then re...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0165-1781(94)90004-3
更新日期：1994-11-01 00:00:00
abstract：:A notable number of young adults struggle to control impulsive behavior, resulting in impairment and distress. Assessments of problematic sexual behavior (PSB) have noted clinical differences relative to other populations, but neurocognitive findings have varied. This analysis assesses the clinical presentation and ne...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.09.044
更新日期：2016-12-30 00:00:00
abstract：:Six schizophrenic patients had their urinary peptide levels measured before and after 5 weeks of treatment with neuroleptic medications. For two patients, levels were also measured after a reduction in the neuroleptic dose. Because of the heterogeneity of peptide peaks with the same bioactivity, the overall peptide le...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(95)02629-b
更新日期：1995-09-29 00:00:00
abstract：:In mental health services research, analyzing service utilization data often poses serious problems, given the presence of substantially skewed data distributions. This article presents a non-technical introduction to statistical methods specifically designed to handle the complexly distributed datasets that represent...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2007.07.003
更新日期：2008-08-15 00:00:00
abstract：:We conducted a retrospective chart-review study, examining predictors of the repetition of short-term self-harm (<1 month and <6 months) among the patients who were admitted to an emergency department in Japan following self-harm. A total of 405 patients were enrolled and were followed-up for a subsequent one year. Th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.08.077
更新日期：2017-12-01 00:00:00
abstract：:One of the leading biosocial theories of borderline personality disorder (BPD) suggests that individuals with BPD have biologically based abnormalities in emotion regulation contributing to more intense and rapid responses to emotional stimuli, in particular, invalidation [Linehan, M.M., 1993. Cognitive-Behavioral Tre...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.06.007
更新日期：2008-01-15 00:00:00
abstract：:The association between early childhood infections and the risk of schizophrenia is not clear, and this study aimed to investigate the association between childhood infections and the risk of schizophrenia in a population-based Australia male cohort. A population-based cohort of males born between 1980 and 1984 in Wes...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.06.007
更新日期：2012-12-30 00:00:00
abstract：:Twenty-two patients who met the Utah criteria for attention deficit disorder, residual type (hyperactivity, minimal brain dysfunction in adults) received an open trial of pargyline (Eutonyl). Of these 22 patients, 13 (59%) showed a moderate to marked therapeutic response. Clinically useful features of pargyline in the...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(83)90006-9
更新日期：1983-08-01 00:00:00
abstract：:Cognitive impairments in schizophrenia have been recognized as a prominent feature of the illness. Research is now focusing on determining a relationship between neurocognitive impairments, and social and functional outcome. Despite a number of comprehensive reviews on neurocognitive measures and reports on spatial wo...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2006.03.018
更新日期：2007-03-30 00:00:00
abstract：:Evaluating whether certain subtypes of Major Depressive Disorder (MDD) are more strongly associated with Substance Use Disorders (SUDs) may help clarify reasons for MDD-SUD relations. Therefore, this study compared DSM-IV-defined non-atypical/non-melancholic depression (undifferentiated depression; n=365), atypical de...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.10.014
更新日期：2008-10-30 00:00:00
abstract：:Because some evidence favors the hyperarousal model of insomnia, we sought to learn more about the dynamics of this phenomenon during sleep. Polysomnographic data from 30 normative subjects and 86 untreated primary insomnia sufferers recruited from the database of the sleep laboratory were studied for whole nights and...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.03.045
更新日期：2017-07-01 00:00:00
abstract：:This study examined the impact of bombing on posttraumatic stress disorder (PTSD) and psychiatric co-morbidity over time, whether this relationship was mediated by shattered world assumptions and altered self-capacities, and whether the mediational effects were moderated by attachment style and crisis support among Ir...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.01.001
更新日期：2019-03-01 00:00:00
abstract：:To investigate the effect of the count of traumatizing event (TE) types on post-trauma mental health, several studies have compared posttraumatic stress disorder (PTSD) severity between individuals experiencing one versus multiple TE types. However, the validity of these studies depends on the establishment of measure...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.03.065
更新日期：2018-06-01 00:00:00
abstract：:The neurotrophin, brain-derived neurotrophic factor (BDNF), characterises a probable neurobiochemical explanation of maldevelopments in schizophrenia and is a candidate biomarker of the illness. A paucity of studies examining neurobiochemical predictors of remission in schizophrenia exists. In this study, we seek to e...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.07.079
更新日期：2014-12-15 00:00:00
abstract：:Individuals who differ markedly by sleep chronotype, i.e., morning-type or evening-type also differ on a number of psychological, behavioral, and biological variables. Among several other psychological functions, dissociation may also lead to disruption and alteration of consciousness, which may facilitate dream-like ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.06.059
更新日期：2017-10-01 00:00:00
abstract：:Imaging studies in patients with Type II alcohol dependence have revealed significant reductions in dopamine (DA) D2 receptor availability. Here we assessed the effects of alcohol detoxification in DA D2 receptors in alcoholic subjects. We evaluated 14 patients with Type II alcohol dependence tested within 6 weeks of ...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/s0925-4927(02)00087-2
更新日期：2002-12-30 00:00:00
abstract：:A meta-analysis study reported serum brain-derived neurotrophic factor (BDNF) levels as a potential biomarker for schizophrenia. However, at the time, commercially available human ELISA kits were unable to distinguish between pro-BDNF (precursor BDNF) and mature BDNF, because of limited antibody specificity. Here, we ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.12.009
更新日期：2014-02-28 00:00:00
abstract：:Both personality traits and autonomic functioning show as gender differences, but their relationship is not well understood. Medically unexplained symptoms are related to personality features and can be assessed by autonomic measurement. The patterns are hypothesised to identify gender differences. We recruited 30 mal...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.01.031
更新日期：2013-10-30 00:00:00
abstract：:In recent years, empirical studies have shown that the inability to tolerate distress is associated with a wide range of negative outcomes including eating addiction, drug abuse, alcohol use, and antisocial behavior in adults. However, few studies have examined family correlates of this ability in children. Also, past...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.06.008
更新日期：2018-09-01 00:00:00
abstract：:There is a need for theoretically-based research on the motivational processes linked to the adoption and maintenance of an active lifestyle in people with affective disorders. Within the Self-Determination Theory (SDT) framework, we investigated the SDT tenets in people with major depressive disorder or bipolar disor...
journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究
doi：10.1016/j.psychres.2015.04.021
更新日期：2015-07-30 00:00:00
abstract：:Research on the sub-clinical condition of schizotypy suggests that it is associated with mixed handedness. To date, however, this research has focussed on undergraduate populations. If the association between schizotypy and mixed-handedness is the result of an underlying neurological trait, it is important to demonstr...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.11.019
更新日期：2011-05-15 00:00:00
abstract：:In order to investigate electroencephalographic (EEG) biomarkers of auditory processing for schizophrenia, we studied a group with a well known high-risk profile: patients with 22q11.2 deletion syndrome (22q11 DS) have a 30% risk of developing schizophrenia during adulthood. We performed high-density EEG source imagin...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.09.002
更新日期：2013-05-30 00:00:00
abstract：:Sleep quantity and risky behaviours are important health issues in adolescents. This cross-sectional study aimed to examine the association between short and long nocturnal sleep durations and a variety of adolescent risky behaviours, including suicidality, violence, regular alcohol consumption, illicit drug use, trua...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.02.016
更新日期：2010-08-30 00:00:00
abstract：:A set of face stimuli called the NimStim Set of Facial Expressions is described. The goal in creating this set was to provide facial expressions that untrained individuals, characteristic of research participants, would recognize. This set is large in number, multiracial, and available to the scientific community onli...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.05.006
更新日期：2009-08-15 00:00:00
abstract：:New methods for using ketamine in patients with propofol-electroconvulsive therapy-resistant depression (ECT-RD) are needed in the clinic. This study aimed to investigate the therapeutic efficacy of ketamine plus ECT in ECT-RD patients, along with the treatment-induced brain alterations. A total of 28 ECT-RD patients ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.112907
更新日期：2020-05-01 00:00:00
abstract：:Social separation is a risk factor for major depressions that can be modeled in nonhuman primates. Changes in central monoamine neurotransmission are also likely to be involved in major depression. This study examined the relationship between separation-induced depressive-like behavior and central monoamine neurotrans...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(84)90004-0
更新日期：1984-04-01 00:00:00
