Early childhood infections and risk of schizophrenia.

Abstract:

:The association between early childhood infections and the risk of schizophrenia is not clear, and this study aimed to investigate the association between childhood infections and the risk of schizophrenia in a population-based Australia male cohort. A population-based cohort of males born between 1980 and 1984 in Western Australia was identified using birth registry records and followed-up until December 31st, 2009 or death using linked health data available through the Western Australian Data Linkage System. The associations between hospitalized infections occurring during 0-3yr of age and risk of schizophrenia were assessed with stratified analysis and multivariate logistic regression models. Analysis was further repeated to assess the effect of hospitalized intestinal infections (gastroenteritis) and respiratory infections. It was observed that male participants with two or more hospitalizations for infections before the age of three had an 80% higher risk of schizophrenia, and these findings remained when the analysis was limited to intestinal infections and acute respiratory infections. These findings support the hypothesis that infections during early childhood may lead to the onset of schizophrenia in later life.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Liang W,Chikritzhs T

doi

10.1016/j.psychres.2012.06.007

subject

Has Abstract

pub_date

2012-12-30 00:00:00

pages

214-7

issue

2-3

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(12)00318-6

journal_volume

200

pub_type

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