Childhood trauma predicts multiple, high lethality suicide attempts in patients with schizophrenia.


:Childhood trauma has been shown to increase the risk of suicide attempts in individuals with schizophrenia. However, previous literature has been limited by considerable heterogeneity within the category of suicide attempters. Here we tested the predictive effect of childhood maltreatment on lifetime suicide attempt in a homogeneous sample of 650 patients with schizophrenia spectrum disorders. Childhood trauma was assessed using the Childhood Trauma Questionnaire-Short Form and suicide history was measured using subjective and objective validated scales as well as medical chart reviews. We refined our sample into two homogenous groups: 1) suicide attempters: patients who had attempted suicide multiple times, with highly lethal results (medical hospitalization required) (n = 24); and 2) non-ideators: patients who had no personal history of suicide attempt or ideation, or family history of attempt (n = 25). Binary logistic regression models revealed that total childhood trauma (β = 0.002; OR: 1.07; 95% CI: 1.00-1.14) and emotional abuse (β = 0.04; OR: 1.38; 95% CI: 1.08-1.77), but not other trauma subtypes, significantly predicted lifetime multiple, high lethality suicide attempts after adjusting for demographic and clinical covariates. Thus, childhood trauma is a weak, independent risk factor for extreme suicide attempts in patients with schizophrenia spectrum disorders.


Psychiatry Res


Psychiatry research


Alli S,Tasmim S,Adanty C,Graff A,Strauss J,Zai C,Gerretsen P,Borlido C,De Luca V




Has Abstract


2019-11-01 00:00:00












  • Noradrenergic and serotonergic input necessary for imipramine-induced changes in beta but not S2 receptor densities.

    abstract::Chronic imipramine administration decreases the density of serotonin S2 and beta-adrenergic receptors. The mode of action is not clear but might be assumed to be a result of imipramine interacting with its high affinity binding sites on presynaptic serotonin neurons. To investigate this possibility and the role of the...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Dumbrille-Ross A,Tang SW

    更新日期:1983-07-01 00:00:00

  • Between- and within-scanner variability in the CaliBrain study n-back cognitive task.

    abstract::Psychiatric neuroimaging techniques are likely to improve understanding of the brain in health and disease, but studies tend to be small, based in one imaging centre and of unclear generalisability. Multicentre studies have great appeal but face problems if functional magnetic resonance imaging (fMRI) data from differ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Gradin V,Gountouna VE,Waiter G,Ahearn TS,Brennan D,Condon B,Marshall I,McGonigle DJ,Murray AD,Whalley H,Cavanagh J,Hadley D,Lymer K,McIntosh A,Moorhead TW,Job D,Wardlaw J,Lawrie SM,Steele JD

    更新日期:2010-11-30 00:00:00

  • Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's disease.

    abstract::Dementia with Lewy bodies (DLB) is a common form of dementia, with fewer memory deficits, and more visuo-perceptual problems than Alzheimer's disease (AD). We hypothesized that there would be disease specific alterations revealed by diffusion tensor imaging with AD showing temporal lobe and DLB more parietal changes. ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Firbank MJ,Blamire AM,Krishnan MS,Teodorczuk A,English P,Gholkar A,Harrison RM,O'Brien JT

    更新日期:2007-07-15 00:00:00

  • Stroop performance in pathological gamblers.

    abstract::Pathological gambling is a relatively prevalent psychiatric disorder that typically leads to severe family, social, legal, and occupational problems and is associated with a high rate of suicide attempts. Understanding the neurobiological basis of pathological gambling is a current focus of research, and emerging data...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kertzman S,Lowengrub K,Aizer A,Nahum ZB,Kotler M,Dannon PN

    更新日期:2006-05-30 00:00:00

  • Shorter gaze duration for happy faces in current but not remitted depression: evidence from eye movements.

    abstract::Cognitive theories of depression propose that depressed individuals preferentially attend to negative information and that such cognitive biases constitute important vulnerability and maintenance factors for the disorder. Most studies examined this bias by registration of response latencies. The present study employed...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Isaac L,Vrijsen JN,Rinck M,Speckens A,Becker ES

    更新日期:2014-08-15 00:00:00

  • Impulsivity in depressed children and adolescents: a comparison between behavioral and neuropsychological data.

    abstract::Impulsivity at the neuropsychological and behavioral levels was investigated in a sample of drug-naive depressed children and adolescents. The performance of 21 patients with a current diagnosis of mood disorder was compared with that of 21 normal controls on tests of executive functions related to impulsivity (Matchi...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Cataldo MG,Nobile M,Lorusso ML,Battaglia M,Molteni M

    更新日期:2005-09-15 00:00:00

  • Ability to use the wait-and-see strategy in pathological gamblers.

    abstract::Pathological gamblers (PGs) perform differently on neurocognitive tests than do healthy controls (HC). The aim of this study was to assess "waiting ability" - a major components of inhibition control-using a modified Stop Signal Task (SST) in a population of male PGs (N=55), and HCs (N=53). Results indicated no differ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kertzman S,Vainder M,Visne T,Aizer A,Kotler M,Dannon PN

    更新日期:2015-12-15 00:00:00

  • Internalized mental illness stigma and subjective well-being: The mediating role of psychological well-being.

    abstract::This study examines the relationships between internalized stigma, psychological well-being, and subjective well-being in a sample of people with mental illness. We conducted a cross-sectional study with 213 outpatients from the Spanish public social care network. The results showed that (a) internalized stigma was si...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Pérez-Garín D,Molero F,Bos AE

    更新日期:2015-08-30 00:00:00

  • The psychological impact of the COVID-19 epidemic on college students in China.

    abstract::A COVID-19 epidemic has been spreading in China and other parts of the world since December 2019. The epidemic has brought not only the risk of death from infection but also unbearable psychological pressure. We sampled college students from Changzhi medical college by using cluster sampling. They responded to a quest...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Cao W,Fang Z,Hou G,Han M,Xu X,Dong J,Zheng J

    更新日期:2020-05-01 00:00:00

  • The role of anxiety sensitivity in the experience of menstrual-related symptoms reported via daily diary.

    abstract::The current study examined the interactive effects of Anxiety Sensitivity (AS) and menstrual cycle phase in the experience of menstrual-related symptoms. Participants were 55 community women who completed prospective tracking of menstrual-related symptoms across at least one full menstrual cycle using the Daily Record...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Nillni YI,Rohan KJ,Mahon JN,Pineles SL,Zvolensky MJ

    更新日期:2013-12-15 00:00:00

  • Associations between trait anhedonia and emotional memory deficits in females with schizophrenia versus major depression.

    abstract::Individuals with schizophrenia (SZ) and individuals with major depressive disorder (MDD) demonstrate impaired emotional memory and decreased enjoyment of pleasant experiences (e.g., anhedonia). However, it is unclear whether these impairments reflect similar or different processes in the two diagnostic groups. This st...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Olsen EK,Bjorkquist OA,Bodapati AS,Shankman SA,Herbener ES

    更新日期:2015-12-15 00:00:00

  • Serum prolactin levels following intramuscular chlorpromazine: two- and three-hour response as predictors of six-hour response.

    abstract::Neuroendocrine studies that examine the changes in serum prolactin levels following intramuscular (im) neuroleptics have usually monitored prolactin levels before and for 90 minutes to 3 hours after neuroleptic injection. Recent studies have suggested that this may be an inadequate period of time. In the present study...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Busch DA,Fang VS,Meltzer HY

    更新日期:1979-10-01 00:00:00

  • Experimental and quasi-experimental designs in implementation research.

    abstract::Implementation science is focused on maximizing the adoption, appropriate use, and sustainability of effective clinical practices in real world clinical settings. Many implementation science questions can be feasibly answered by fully experimental designs, typically in the form of randomized controlled trials (RCTs). ...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审


    authors: Miller CJ,Smith SN,Pugatch M

    更新日期:2020-01-01 00:00:00

  • Assertive outreach for "difficult to engage" patients: A useful tool for a subgroup of patients in specialized early psychosis intervention programs.

    abstract:PURPOSE:Most specialized Early Psychosis (EP) programs include assertive outreach (AO) principles, either for all patients or as an intensive case management (ICM) subprogram in selected situations. The objective of this study is to examine prevalence, characteristics and outcomes of patients who needed additional ICM ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Alameda L,Golay P,Baumann P,Morandi S,Ferrari C,Conus P,Bonsack C

    更新日期:2016-05-30 00:00:00

  • Postpartum stress and infant outcome: A review of current literature.

    abstract::Postpartum stress has been shown to have an association with infant growth, nutrition, bonding, temperament and ultimately childhood mental wellbeing. When persistent, recurring or chronic, it can negatively impact infant outcome, including the subscales of mental wellbeing such as growth, development, feeding, attach...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审


    authors: Oyetunji A,Chandra P

    更新日期:2020-02-01 00:00:00

  • A latent class analysis of DSM-IV pathological gambling criteria in a nationally representative British sample.

    abstract::This study identified empirically derived subtypes of gamblers based on the Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) diagnostic criteria for pathological gambling disorder (PGD). Data from the gamblers (n=5644) who participated in the 2007 British Gambling Prevalence Survey (BGPS) were analyse...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: McBride O,Adamson G,Shevlin M

    更新日期:2010-07-30 00:00:00

  • Spontaneous eye blink rate in winter seasonal affective disorder.

    abstract::We investigated spontaneous eye-blink rates in 19 drug-free patients with winter seasonal affective disorder (SAD) and 18 normal control subjects. At baseline, there were no significant differences between the two groups (mean +/- SD blink rate: 15/minute +/- 8 vs. 15/minute +/- 7). Light therapy (10,000 lux: 1 hour e...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章


    authors: Barbato G,Moul DE,Schwartz P,Rosenthal NE,Oren DA

    更新日期:1993-04-01 00:00:00

  • The spark that might have ignited the fire: The association of cognitive and psychological factors with state anxiety in light of the Syrian-Israeli incident.

    abstract::The current study aimed to explore Israelis' state anxiety due to a Syrian-Israeli incident that occurred on February 10, 2018, when an Israeli F-16 fighter jet was shot down by Syrian air defense forces. In line with the "looming vulnerability" model which emphasizes the importance of the dynamic nature of psychologi...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Hamama-Raz Y,Mahat-Shamir M,Ring L,Pitcho-Prelorentzos S,Ben-Ezra M

    更新日期:2018-12-01 00:00:00

  • Hemispheric asymmetry of primary auditory cortex and Heschl's gyrus in schizophrenia and nonpsychiatric brains.

    abstract::Heschl's gyrus (HG) is reported to have a normal left>right hemispheric volume asymmetry, and reduced asymmetry in schizophrenia. Primary auditory cortex (A1) occupies the caudal-medial surface of HG, but it is unclear if A1 has normal asymmetry, or whether its asymmetry is altered in schizophrenia. To address these i...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Smiley JF,Hackett TA,Preuss TM,Bleiwas C,Figarsky K,Mann JJ,Rosoklija G,Javitt DC,Dwork AJ

    更新日期:2013-12-30 00:00:00

  • Assessment of tryptophan metabolism and signs of depression in individuals with carbohydrate malabsorption.

    abstract::This prospective cross-sectional study aimed to investigate the potential association between primary-adult lactose malabsorption, fructose malabsorption, tryptophan (TRP) metabolism and the presence of depressive signs. Overall 251 patients, who were referred for lactase gene C/T-13910 polymorphism genotyping and fru...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Enko D,Wagner H,Kriegshäuser G,Brandmayr W,Halwachs-Baumann G,Schnedl WJ,Zelzer S,Mangge H,Meinitzer A

    更新日期:2018-04-01 00:00:00

  • Investigation of the Montreal Cognitive Assessment (MoCA) as a cognitive screener in severe mental illness.

    abstract::This study examined the Montreal Cognitive Assessment (MoCA) as a neurocognitive screener and its relationship with functional outcomes in a sample of outpatients diagnosed with severe mental illness (SMI). The MoCA, Brief Assessment of Cognition in Schizophrenia (BACS), UCSD Performance-Based Skills Assessment Test-2...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Musso MW,Cohen AS,Auster TL,McGovern JE

    更新日期:2014-12-15 00:00:00

  • T-helper types 1, 2, and 3 cytokine interactions in symptomatic manic patients.

    abstract::It has been reported that the balance between T-helper type 1 (Th1) cytokines and T-helper type 2 (Th2) cytokines plays a role in psychiatric disorders such as bipolar disorder. The T-helper type 3 (Th3) cytokine, which transforming growth factor beta-1 (TGF-beta1), has been shown to modulate the production of Th1 and...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kim YK,Myint AM,Lee BH,Han CS,Lee SW,Leonard BE,Steinbusch HW

    更新日期:2004-12-30 00:00:00

  • Child loss and psychosis onset: evidence for traumatic experience as an etiological factor in psychosis.

    abstract::Previous research suggests that trauma may contribute to psychosis onset. In this study, we examine the effect of parental loss of a child on the onset of psychotic experience using data from the National Comorbidity Survey Replication, hypothesizing that child loss will precede the onset of psychosis and will be asso...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Devylder JE,Wang JS,Oh HY,Lukens EP

    更新日期:2013-01-30 00:00:00

  • Age at onset and gender resemblance in bipolar siblings.

    abstract::In order to measure the intrafamilial correlation for age at onset and to examine gender resemblance among bipolar siblings, we assessed a sample of 130 bipolar patients belonging to 59 multiple affected sibships. To study the intrafamilial resemblance for age at onset and gender, we used the intraclass correlation an...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Leboyer M,Bellivier F,McKeon P,Albus M,Borrman M,Perez-Diaz F,Mynett-Johnson L,Feingold J,Maier W

    更新日期:1998-11-16 00:00:00

  • No association between bipolar affective disorder and a serotonin receptor (5-HT2A) polymorphism.

    abstract::The serotonergic system is implicated in the pathogenesis of affective disorders. In particular, the role of the postsynaptic 5-hydroxytryptamine (serotonin) type 2 receptor (5-HT2) has been documented by several studies. The 5-HT2A receptor gene located on chromosome 13 (13q14-21) can be considered a candidate gene f...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Mahieu B,Souery D,Lipp O,Mendelbaum K,Verheyen G,De Maertelaer V,Van Broeckhoven C,Mendlewicz J

    更新日期:1997-05-05 00:00:00

  • Lowered omega3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients.

    abstract::Depression is associated with a lowered degree of esterification of serum cholesterol, an increased C20:4omega6/C20:5omega3 ratio and decreases in omega3 fractions in fatty acids (FAs) or in the red blood cell membrane. The aims of the present study were to examine: (i) serum phospholipid and cholesteryl ester composi...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章


    authors: Maes M,Christophe A,Delanghe J,Altamura C,Neels H,Meltzer HY

    更新日期:1999-03-22 00:00:00

  • Explicit self-esteem mediates the relationship between implicit self-esteem and memory biases in major depression.

    abstract::This study examines the relationships between explicit and implicit self-esteem and self-referent memory biases in depression. We specifically tested the hypothesis that implicit self-esteem would influence depression-related memory biases via its association with explicit self-esteem. Self-esteem was assessed in pati...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Romero N,Sanchez A,Vázquez C,Valiente C

    更新日期:2016-08-30 00:00:00

  • Low HVA and normal 5HIAA CSF levels in drug-free schizophrenic patients compared to healthy volunteers: correlations to symptomatology and family history.

    abstract::Cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5HIAA) were determined in 40 drug-free schizophrenic patients and 21 healthy volunteers by a mass fragmentographic method. Twenty-one of the schizophrenic patients were first admissions who had never received neuroleptics. Sign...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Lindström LH

    更新日期:1985-04-01 00:00:00

  • Emotional blunting following left basal ganglia stroke: the role of depression and fronto-limbic functional alterations.

    abstract::Disorders of the basal ganglia (BG) alter perception and experience of emotions. Left hemisphere BG (LBG) stroke is also associated with depression. The interplay between depression and alterations in emotional processing following LBG stroke was examined. Evoked affective responses to emotion-laden pictorial stimuli ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Paradiso S,Ostedgaard K,Vaidya J,Ponto LB,Robinson R

    更新日期:2013-02-28 00:00:00

  • Cognitive style in bipolar disorder sub-types.

    abstract::Clearer understanding of psychological processes and mechanisms such as cognitive style inform more targeted psychological treatments for mood disorders. Studies to date have focused on bipolar I disorder or combined bipolar sub-types, precluding identification of any distinctive cognitive style profiles. We examined ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Fletcher K,Parker G,Manicavasagar V

    更新日期:2013-04-30 00:00:00