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The VA augmentation and switching treatments for improving depression outcomes (VAST-D) study: Rationale and design considerations.

Abstract：

:Because two-thirds of patients with Major Depressive Disorder do not achieve remission with their first antidepressant, we designed a trial of three "next-step" strategies: switching to another antidepressant (bupropion-SR) or augmenting the current antidepressant with either another antidepressant (bupropion-SR) or with an atypical antipsychotic (aripiprazole). The study will compare 12-week remission rates and, among those who have at least a partial response, relapse rates for up to 6 months of additional treatment. We review seven key efficacy/effectiveness design decisions in this mixed "efficacy-effectiveness" trial.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Mohamed S,Johnson GR,Vertrees JE,Guarino PD,Weingart K,Young IT,Yoon J,Gleason TC,Kirkwood KA,Kilbourne AM,Gerrity M,Marder S,Biswas K,Hicks P,Davis LL,Chen P,Kelada A,Huang GD,Lawrence DD,LeGwin M,Zisook S

doi

10.1016/j.psychres.2015.08.005

subject

Has Abstract

pub_date

2015-10-30 00:00:00

pages

760-70

issue

3

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(15)00556-9

journal_volume

229

pub_type

杂志文章,随机对照试验

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