Abstract：
:Four groups of children referred for attention disorders, learning disorders, or both were blindly titrated at statistically equivalent dosage levels of methylphenidate and improved more or less equivalently on several measures of attentiveness (cognitive style tests and reaction time). Methylphenidate dosage needs, which vary considerably, appear more strongly related to indices of nervous system sensitivity than clinical diagnosis. Interactions of stimulus intensity, reward level, and drug condition on reaction time (RT) lend credence to the theoretical constructs of augmentation-reduction and nervous system sensitivity. Order of treatment (placebo before drug or drug before placebo) had an unexpected effect on RT, suggesting that on a boring, frustrating task, methylphenidate may enhance performance less as a function of number of exposures to the experience.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Ackerman PT,Dykman RA,Holcomb PJ,McCray DSdoi
10.1016/0165-1781(92)90093-isubject
Has Abstractpub_date
1982-10-01 00:00:00pages
199-213issue
2eissn
0165-1781issn
1872-7123pii
0165-1781(92)90093-Ijournal_volume
7pub_type
临床试验,杂志文章abstract：:Resting state functional magnetic resonance imaging (fMRI) was used to measure whole brain functional connectivity within specific networks hypothesised to be more affected in dementia with Lewy bodies (DLB) (a disease characterised by prominent attentional deficits, spontaneous motor features of parkinsonism and depr...
journal_title：Psychiatry research
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journal_title：Psychiatry research
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journal_title：Psychiatry research
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