Hippocampal FXR plays a role in the pathogenesis of depression: A preliminary study based on lentiviral gene modulation.


:As a well-known bile acid receptor, the role of Farnesoid X receptor (FXR) in the digestive system and cardiovascular system has been widely explored. However, there are very few studies involving FXR in the central nervous system. In this study, we explored the role of FXR in the pathogenesis of depression, a serious and worldwide neuropsychiatric disease. It was found that chronic unpredictable mild stress (CUMS) fully enhanced the protein and mRNA expressions of FXR in hippocampus, but not medial prefrontal cortex (mPFC). Overexpression of hippocampal FXR induced notable depressive-like behaviors and decreased expression of brain-derived neurotrophic factor (BDNF) in naïve rats, while knockdown of hippocampal FXR fully prevented the effects of CUMS on rat behaviors and hippocampal BDNF expression. Taken together, our research extends the knowledge of FXR's role in the central nervous system, and may provide a potential and novel therapeutic target for treating depression.


Psychiatry Res


Psychiatry research


Chen WG,Zheng JX,Xu X,Hu YM,Ma YM




Has Abstract


2018-06-01 00:00:00












  • Caffeine taste test for panic disorder: adenosine receptor supersensitivity.

    abstract::The present study introduces a novel measure of adenosine receptor sensitivity that is based on the action of specific receptor blockers (e.g., caffeine) to potentiate the ability to detect threshold quinine concentrations. The test is used to compare gustatory adenosinergic responses to caffeine challenges in normal ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: DeMet E,Stein MK,Tran C,Chicz-DeMet A,Sangdahl C,Nelson J

    更新日期:1989-12-01 00:00:00

  • Behavioural studies of spatial working memory dysfunction in schizophrenia: a quantitative literature review.

    abstract::Cognitive impairments in schizophrenia have been recognized as a prominent feature of the illness. Research is now focusing on determining a relationship between neurocognitive impairments, and social and functional outcome. Despite a number of comprehensive reviews on neurocognitive measures and reports on spatial wo...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审


    authors: Piskulic D,Olver JS,Norman TR,Maruff P

    更新日期:2007-03-30 00:00:00

  • Decreased default-mode network homogeneity in unaffected siblings of schizophrenia patients at rest.

    abstract::The dysconnectivity hypothesis proposes that abnormal resting state connectivity within the default-mode network (DMN) plays a key role in schizophrenia. Little is known, however, about alterations of the network homogeneity (NH) of the DMN in unaffected siblings of patients with schizophrenia. Unaffected siblings hav...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Guo W,Liu F,Yao D,Jiang J,Su Q,Zhang Z,Zhang J,Yu L,Zhai J,Xiao C

    更新日期:2014-12-30 00:00:00

  • A pilot study to investigate the induction and manipulation of learned helplessness in healthy adults.

    abstract::Eliminating the controllability of a noxious stimulus may induce a learned helplessness (LH) that resembles aspects of depression and post-traumatic stress disorder (PTSD). This study examined whether repetitive transcranial magnetic stimulation (rTMS) of the left dorsolateral prefrontal cortex (DLPFC) promotes resili...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Taylor JJ,Neitzke DJ,Khouri G,Borckardt JJ,Acierno R,Tuerk PW,Schmidt M,George MS

    更新日期:2014-11-30 00:00:00

  • The associations among childhood maltreatment, "male depression" and suicide risk in psychiatric patients.

    abstract::In the current cross-sectional study, we aimed to investigate the presence and severity of "male" depressive symptoms and suicidal behaviors in psychiatric patients with and without a history of child abuse and neglect, as measured by the Childhood Trauma Questionnaire (CTQ), as well as to explore the associations amo...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Pompili M,Innamorati M,Lamis DA,Erbuto D,Venturini P,Ricci F,Serafini G,Amore M,Girardi P

    更新日期:2014-12-15 00:00:00

  • Semantic priming in major depressive state.

    abstract::We studied semantic priming in 20 major depressive subjects. The methodology used was a visual lexical decision task. Semantic priming is the facilitation of target word recognition (shortening of response time) by the prior presentation of a semantically related context (a prime word). It relies on semantic processin...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Georgieff N,Dominey PF,Michel F,Marie-cardine M,Dalery J

    更新日期:1998-03-20 00:00:00

  • Auditory event-related potentials in schizophrenia and depression.

    abstract::Event-related potentials in two auditory target detection paradigms and two auditory paradigms without overt tasks were studied in 22 schizophrenic, 21 depressed, and 28 matched control subjects meeting Research Diagnostic Criteria. In the target detection paradigms, schizophrenics showed a pattern of reduced N120 amp...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Roth WT,Pfefferbaum A,Kelly AF,Berger PA,Kopell BS

    更新日期:1981-04-01 00:00:00

  • Could autonomous motivation hold the key to successfully implementing lifestyle changes in affective disorders? A multicentre cross sectional study.

    abstract::There is a need for theoretically-based research on the motivational processes linked to the adoption and maintenance of an active lifestyle in people with affective disorders. Within the Self-Determination Theory (SDT) framework, we investigated the SDT tenets in people with major depressive disorder or bipolar disor...

    journal_title:Psychiatry research

    pub_type: 杂志文章,多中心研究


    authors: Vancampfort D,Madou T,Moens H,De Backer T,Vanhalst P,Helon C,Naert P,Rosenbaum S,Stubbs B,Probst M

    更新日期:2015-07-30 00:00:00

  • Risk indicators for post-traumatic stress disorder in adolescents exposed to the 5.12 Wenchuan earthquake in China.

    abstract::In Chinese adolescents exposed to the Wenchuan earthquake, we used the Children's Revised Impact of Event Scale (CRIES) as the screening tool, and Post-traumatic Cognitions Inventory (PTCI) and the Social Support Rating Scale (SSRS) were used to assess the cognitive status and their social supports, to evaluate the pr...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Ma X,Liu X,Hu X,Qiu C,Wang Y,Huang Y,Wang Q,Zhang W,Li T

    更新日期:2011-10-30 00:00:00

  • Cortisol levels before and after cognitive behavioural therapy in patients with eating disorders reporting childhood abuse: A follow-up study.

    abstract::The etiopathogenesis of eating disorders (EDs) is complex and still not well understood. Biological, psychological and environmental factors (e.g. childhood abuse) have all been considered to be involved in the onset and the persistence of EDs. The hypothalamic-pituitary-adrenal (HPA) axis is a relevant biological fac...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Lelli L,Castellini G,Cassioli E,Monteleone AM,Ricca V

    更新日期:2019-05-01 00:00:00

  • Early signs of worry: psychosis risk symptom visual distortions are independently associated with suicidal ideation.

    abstract::Previous studies have shown an association between suicidal behavior and schizophrenia. However, little is known about this association in those with psychotic experiences and symptoms that do not meet the criteria for full psychosis. The aim of the study was to investigate how psychosis risk symptoms are associated w...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Granö N,Salmijärvi L,Karjalainen M,Kallionpää S,Roine M,Taylor P

    更新日期:2015-02-28 00:00:00

  • Pain Avoidance and Its Relation to Neural Response to Punishment Characterizes Suicide Attempters with Major Depression Disorder.

    abstract::Diminished neural responses to punitive stimulus related to high level of pain avoidance may be biomarkers in distinguishing patients with history of suicide attempts from those without such histories. Outpatients with Major Depression Disorder (MDD, n=44) and healthy controls (HCs, n=28) were administered the Beck De...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Song W,Li H,Sun F,Guo T,Jiang S,Wang X

    更新日期:2020-12-01 00:00:00

  • Structural abnormalities of the right inferior colliculus in schizophrenia.

    abstract::Although structural and functional neuroimaging studies of schizophrenia have suggested that impaired connectivity in the extensive network of cortical and subcortical areas is involved in its pathophysiology, there were no studies have investigated the structural integrity of the lower sensory brain areas including t...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Kang DH,Kwon KW,Gu BM,Choi JS,Jang JH,Kwon JS

    更新日期:2008-11-30 00:00:00

  • Psychomotor changes in melancholic and atypical depression: unipolar and bipolar-II subtypes.

    abstract::Psychomotor changes are reported to be 'nearly always present' in the melancholic subtype of major depressive episode (MDE) in DSM-IV-TR, and are believed by some researchers to be markers of melancholia. The aim of this study was to compare melancholic and atypical forms of MDE and to determine whether psychomotor ch...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Benazzi F

    更新日期:2002-11-15 00:00:00

  • Relationships between patients' attachment characteristics and views and use of psychiatric treatment.

    abstract::This study explored the influence of attachment on psychiatric treatment by considering attitudes towards and the use of psychotropic medication and psychotherapy in patients with depressive and anxiety disorders. Adults referred to a psychiatrist completed self-report measures and participated in a diagnostic intervi...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Adams GC,McWilliams LA,Wrath AJ,Adams S,Souza D

    更新日期:2017-10-01 00:00:00

  • Lifetime medical and psychiatric comorbidity of night eating behavior in the Swedish Twin Study of Adults: Genes and Environment (STAGE).

    abstract::The medical and psychosocial comorbidity of two core features of night eating syndrome (NES), evening hyperphagia (EH) and nocturnal awakening and ingestion of food (NI), was evaluated in adults enrolled in the Swedish Twin Study of Adults: Genes and Environment (STAGE) study. As part of the STAGE study, more than 20,...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Lundgren JD,Allison KC,Stunkard AJ,Bulik CM,Thornton LM,Karin Lindroos A,Rasmussen F

    更新日期:2012-09-30 00:00:00

  • Attentional abilities and measures of schizotypy: their variation and covariation in schizophrenic patients, their siblings, and normal control subjects.

    abstract::Thirty-five schizophrenic patients in the early stages of illness, 26 of their healthy siblings, and 35 normal control subjects performed the Continuous Performance Test, Identical Pairs version (CPT-IP). Both schizophrenic patients and their siblings were significantly impaired in their attentional performance compar...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Franke P,Maier W,Hardt J,Hain C,Cornblatt BA

    更新日期:1994-12-01 00:00:00

  • Switch the itch: a naturalistic follow-up study on the neural correlates of cognitive flexibility in obsessive-compulsive disorder.

    abstract::Obsessive-compulsive disorder (OCD) is a relatively common psychiatric disorder characterized by intrusive thoughts and behaviors that dominate daily living, like an itch patients cannot ignore. Deficits in executive functioning are common in OCD and are thought to be related to dysfunctional frontal-striatal systems....

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Vriend C,de Wit SJ,Remijnse PL,van Balkom AJ,Veltman DJ,van den Heuvel OA

    更新日期:2013-07-30 00:00:00

  • Smooth pursuit and saccadic eye movements and neurological soft signs in obsessive-compulsive disorder.

    abstract::Patients with obsessive-compulsive disorder (OCD) demonstrate an increased number of neurological soft signs as well as neuroanatomic abnormalities detected with modern imaging techniques. Quantitative analysis of eye movements has proved fruitful in investigations of other neuropsychiatric disorders with similar find...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Nickoloff SE,Radant AD,Reichler R,Hommer DW

    更新日期:1991-08-01 00:00:00

  • Regional brain serotonin and dopamine transporter binding capacity in suicide attempters relate to impulsiveness and mental energy.

    abstract::To study different aspects of regional pre-synaptic brain (123)I-beta-CIT uptake on serotonin and dopamine re-uptake sites in drug-free suicide attempters in comparison with age- and sex matched control subjects, single photon emission computed tomography (SPECT) measurements were analysed for regional serotonin re-up...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Ryding E,Ahnlide JA,Lindström M,Rosén I,Träskman-Bendz L

    更新日期:2006-12-01 00:00:00

  • Parental separation in childhood, social capital, and suicide thoughts and suicide attempts: A population-based study.

    abstract::Studies of the association between parental separation in childhood and suicide thoughts and attempts are scarce. The aim of this study is to investigate associations between parental separation/divorce during childhood, and ever having had suicide thoughts and ever having made suicide attempt, adjusting for social ca...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Lindström M,Rosvall M

    更新日期:2015-09-30 00:00:00

  • Failure to replicate linkage between chromosome 5q11-q13 markers and schizophrenia in 28 families.

    abstract::Sherrington et al. (1988) reported linkage between markers located on the 5q11-q13 region of chromosome 5 and schizophrenia in five Icelandic and two British families. To date, however, all attempts to replicate the initial finding have failed. Using three markers of chromosome 5, we have studied 28 additional French ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Campion D,d'Amato T,Laklou H,Sabate O,Jay M,Leboyer M,Malafosse A,Gorwood P,Babron MC,Hillaire D

    更新日期:1992-12-01 00:00:00

  • Cooperative versus competitive influences of emotion and cognition on decision making: A primer for psychiatry research.

    abstract::Clinical research across the developmental spectrum increasingly reveals the nuanced ways in which emotion and cognition can work to either support or derail rational (i.e., healthy or goal-consistent) decision making. However, psychological theories offer discrepant views on how these processes interact, and on wheth...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审


    authors: Chick CF

    更新日期:2019-03-01 00:00:00

  • CSF-hypocretin-1 levels in patients with major depressive disorder compared to healthy controls.

    abstract::Depressive patients exhibit symptoms of impaired regulation of wakefulness with hyperarousal and agitation as well as difficulties to falling asleep and preserving sleep continuity. Changes in hypocretin (hcrt) levels as polypeptides with impact on arousal and sleep-wake-regulation have been discussed in affective dis...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Schmidt FM,Arendt E,Steinmetzer A,Bruegel M,Kratzsch J,Strauss M,Baum P,Hegerl U,Schönknecht P

    更新日期:2011-12-30 00:00:00

  • The effects of noradrenaline and alpha-2 adrenoceptor agents on the production of monocytic products.

    abstract::There are some reports that catecholamines may modulate the production of monocytic cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF alpha). The present study was carried out in order to examine the effects of noradrenaline (10(-5), 10(-6) and 10(-7) M), clonidine (10(-5), 10(-6) and 10(-7) ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Maes M,Lin A,Kenis G,Egyed B,Bosmans E

    更新日期:2000-11-20 00:00:00

  • What do childhood attention deficit/hyperactivity symptoms in depressed adults tell us about the bipolar spectrum?

    abstract:BACKGROUND:This study aims to establish if adult patients with major depressive disorder (MDD) and childhood Attention Deficit/Hyperactivity disorder (ADHD) symptoms would be more frequently within the bipolar spectrum than depressed patients without childhood ADHD. METHODS:This study was carried out in outpatients re...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Purper-Ouakil D,Porfirio MC,Le Strat Y,Falissard B,Gorwood P,Masi G

    更新日期:2017-03-01 00:00:00

  • Hemispheric asymmetry of primary auditory cortex and Heschl's gyrus in schizophrenia and nonpsychiatric brains.

    abstract::Heschl's gyrus (HG) is reported to have a normal left>right hemispheric volume asymmetry, and reduced asymmetry in schizophrenia. Primary auditory cortex (A1) occupies the caudal-medial surface of HG, but it is unclear if A1 has normal asymmetry, or whether its asymmetry is altered in schizophrenia. To address these i...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Smiley JF,Hackett TA,Preuss TM,Bleiwas C,Figarsky K,Mann JJ,Rosoklija G,Javitt DC,Dwork AJ

    更新日期:2013-12-30 00:00:00

  • Abnormal processing of irrelevant information in chronic schizophrenia: selective enhancement of Stroop facilitation.

    abstract::Thirteen medication-free chronic schizophrenic patients and 11 normal control subjects were administered a trial by trial version of the Stroop Color Naming Task which evaluated separately the processes of interference and facilitation. There was no difference between the groups in the amount of interference to naming...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Carter CS,Robertson LC,Nordahl TE

    更新日期:1992-02-01 00:00:00

  • Neural processing of social exclusion in individuals with psychopathic traits: Links to anger and aggression.

    abstract::Psychopathy is a cluster of personality traits associated with high rates of aggression. While research on psychopathic traits largely focuses on neurobiological factors implicated in aggression, other research suggests that contextual factors, such as social exclusion, also contribute to promoting aggression. Yet, th...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Brennan GM,Crowley MJ,Wu J,Mayes LC,Baskin-Sommers AR

    更新日期:2018-10-01 00:00:00

  • A case of extended-release Quetiapine causing recurrent low-grade fevers.

    abstract::This case highlights recurrent low-grade fevers caused by extended-release Quetiapine (Quetiapine XR), a previously unreported side effect, in a patient with Schizophreniform Disorder. While there have been case reports of Quetiapine causing neuroleptic malignant syndrome, there is paucity of data specifically describ...

    journal_title:Psychiatry research

    pub_type: 信件


    authors: Puthran R,Lai D

    更新日期:2021-01-01 00:00:00