Abstract：
:As a well-known bile acid receptor, the role of Farnesoid X receptor (FXR) in the digestive system and cardiovascular system has been widely explored. However, there are very few studies involving FXR in the central nervous system. In this study, we explored the role of FXR in the pathogenesis of depression, a serious and worldwide neuropsychiatric disease. It was found that chronic unpredictable mild stress (CUMS) fully enhanced the protein and mRNA expressions of FXR in hippocampus, but not medial prefrontal cortex (mPFC). Overexpression of hippocampal FXR induced notable depressive-like behaviors and decreased expression of brain-derived neurotrophic factor (BDNF) in naïve rats, while knockdown of hippocampal FXR fully prevented the effects of CUMS on rat behaviors and hippocampal BDNF expression. Taken together, our research extends the knowledge of FXR's role in the central nervous system, and may provide a potential and novel therapeutic target for treating depression.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Chen WG,Zheng JX,Xu X,Hu YM,Ma YMdoi
10.1016/j.psychres.2018.04.025subject
Has Abstractpub_date
2018-06-01 00:00:00pages
374-379eissn
0165-1781issn
1872-7123pii
S0165-1781(18)30046-5journal_volume
264pub_type
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