Hippocampal FXR plays a role in the pathogenesis of depression: A preliminary study based on lentiviral gene modulation.

Abstract:

:As a well-known bile acid receptor, the role of Farnesoid X receptor (FXR) in the digestive system and cardiovascular system has been widely explored. However, there are very few studies involving FXR in the central nervous system. In this study, we explored the role of FXR in the pathogenesis of depression, a serious and worldwide neuropsychiatric disease. It was found that chronic unpredictable mild stress (CUMS) fully enhanced the protein and mRNA expressions of FXR in hippocampus, but not medial prefrontal cortex (mPFC). Overexpression of hippocampal FXR induced notable depressive-like behaviors and decreased expression of brain-derived neurotrophic factor (BDNF) in naïve rats, while knockdown of hippocampal FXR fully prevented the effects of CUMS on rat behaviors and hippocampal BDNF expression. Taken together, our research extends the knowledge of FXR's role in the central nervous system, and may provide a potential and novel therapeutic target for treating depression.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Chen WG,Zheng JX,Xu X,Hu YM,Ma YM

doi

10.1016/j.psychres.2018.04.025

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

374-379

eissn

0165-1781

issn

1872-7123

pii

S0165-1781(18)30046-5

journal_volume

264

pub_type

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