Abstract：
:Olanzapine is widely used for the treatment of schizophrenia and is considered a first line medication in India. Along with other factors, the variation in response and side effects to this agent may be accounted for by genetic differences among patients. Olanzapine was administered for 6 weeks to Indian subjects with schizophrenia or schizoaffective disorder (DSM-IV, n=130), as part of an open label study. Intent-to-treat analysis was performed, and 10 polymorphic markers from seven genes (dopamine D1, D2, D3 and D4 receptors, serotonin 2A receptor and the drug-metabolizing enzymes (CYP1A2 and CYP2D6)), together with demographic and clinical variables, were analyzed as potential predictors of response. Olanzapine was efficacious, but significant weight gain was noted. Baseline weight and a 120 bp deletion polymorphism at the dopamine receptor D4 (DRD4) gene were associated with changes in symptom scores. Predictable covariates of treatment response were also noted. These results merit replicate studies.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Thomas P,Srivastava V,Singh A,Mathur P,Nimgaonkar VL,Lerer B,Thelma BK,Deshpande SNdoi
10.1016/j.psychres.2007.09.010subject
Has Abstractpub_date
2008-12-15 00:00:00pages
275-83issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(07)00335-6journal_volume
161pub_type
杂志文章abstract：:Previous studies on the factorial structure of the Patient Health Questionnaire (PHQ-9) have yielded divergent results, and there is no consensus on which factorial structure provides a more adequate fit. In Colombia, no precise method to estimate the factorial structure of the PHQ-9 has been used. The purpose of this...
journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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journal_title：Psychiatry research
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究
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journal_title：Psychiatry research
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2009-02-28 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
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更新日期：2018-12-01 00:00:00
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journal_title：Psychiatry research
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2013-10-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2017-07-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2006-10-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.08.050
更新日期：2014-12-30 00:00:00
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/s0165-1781(99)00005-0
更新日期：1999-02-22 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.05.049
更新日期：2017-09-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.09.027
更新日期：2013-07-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.112508
更新日期：2019-10-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.12.018
更新日期：2016-02-28 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
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更新日期：2014-12-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章,评审
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更新日期：2014-12-30 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.pscychresns.2011.08.008
更新日期：2012-02-28 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2020-12-11 00:00:00
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
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更新日期：2003-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.psychres.2015.05.060
更新日期：2015-08-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
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更新日期：2019-03-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.112567
更新日期：2019-11-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.01.001
更新日期：2006-11-15 00:00:00
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/0165-1781(88)90122-9
更新日期：1988-12-01 00:00:00
abstract：:Previous studies that operationalized reactive aggression using behavioral observations in general populations have not taken into account the type of stimulus that elicits reactive aggression. In the present study we define a specific form of reactive aggression, i.e., reactive aggression in response to neutral behav...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.08.006
更新日期：2010-04-30 00:00:00
