Correlates of response to Olanzapine in a North Indian Schizophrenia sample.


:Olanzapine is widely used for the treatment of schizophrenia and is considered a first line medication in India. Along with other factors, the variation in response and side effects to this agent may be accounted for by genetic differences among patients. Olanzapine was administered for 6 weeks to Indian subjects with schizophrenia or schizoaffective disorder (DSM-IV, n=130), as part of an open label study. Intent-to-treat analysis was performed, and 10 polymorphic markers from seven genes (dopamine D1, D2, D3 and D4 receptors, serotonin 2A receptor and the drug-metabolizing enzymes (CYP1A2 and CYP2D6)), together with demographic and clinical variables, were analyzed as potential predictors of response. Olanzapine was efficacious, but significant weight gain was noted. Baseline weight and a 120 bp deletion polymorphism at the dopamine receptor D4 (DRD4) gene were associated with changes in symptom scores. Predictable covariates of treatment response were also noted. These results merit replicate studies.


Psychiatry Res


Psychiatry research


Thomas P,Srivastava V,Singh A,Mathur P,Nimgaonkar VL,Lerer B,Thelma BK,Deshpande SN




Has Abstract


2008-12-15 00:00:00














  • The influence of daytime napping versus controlled activity on the subjective well-being of patients with major depression.

    abstract::While the impact of sleep on cognitive functions such as memory is under extensive study, the role of sleep in modulating a persons' subjective well-being remains largely uncharacterized, especially in groups with psychiatric disorders. To gather more information on this topic a study was conducted with 20 patients su...

    journal_title:Psychiatry research

    pub_type: 杂志文章,随机对照试验


    authors: Peth J,Regen F,Bajbouj M,Heuser I,Anghelescu I,Hornung OP

    更新日期:2012-12-30 00:00:00

  • Anxiety sensitivity and mindful attention in terms of anxiety and depressive symptoms and disorders among Latinos in primary care.

    abstract::The present investigation examined the interactive effects of anxiety sensitivity and mindful attention in relation to anxiety and depressive symptoms and psychopathology among 145 adult Latinos (85.5% female; Mage=39.9, SD=10.8 and 98.6% used Spanish as their first language) who attended a community-based primary hea...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Zvolensky MJ,Bakhshaie J,Garza M,Paulus DJ,Valdivieso J,Lam H,Bogiaizian D,Robles Z,Schmidt NB,Vujanovic A

    更新日期:2015-09-30 00:00:00

  • The role of hippocampus dysfunction in deficient memory encoding and positive symptoms in schizophrenia.

    abstract:BACKGROUND:Declarative memory disturbances, known to substantially contribute to cognitive impairment in schizophrenia, have previously been attributed to prefrontal as well as hippocampal dysfunction. AIMS:To characterize the role of prefrontal and mesolimbic/hippocampal dysfunction during memory encoding in schizoph...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Zierhut K,Bogerts B,Schott B,Fenker D,Walter M,Albrecht D,Steiner J,Schütze H,Northoff G,Düzel E,Schiltz K

    更新日期:2010-09-30 00:00:00

  • Effectiveness of electroconvulsive therapy in patients with treatment resistant schizophrenia: A retrospective study.

    abstract::This study aimed to evaluate the effectiveness of electroconvulsive therapy (ECT) among patients with treatment resistant schizophrenia (TRS). Records of patients who had received ECT were reviewed to identify patients with TRS who were administered ECT in combination with clozapine. Socio-demographic, clinical data a...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Grover S,Chakrabarti S,Hazari N,Avasthi A

    更新日期:2017-03-01 00:00:00

  • Relationships between medication treatments and neuropsychological test performance in schizophrenia.

    abstract::Few investigations have assessed the neuropsychological effects of psychotropic medications on schizophrenic patients. In this study, 44 clinically stable schizophrenic inpatients were administered a battery of neuropsychological tests, and their performance was correlated with dosage of neuroleptic medication and ben...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Sweeney JA,Keilp JG,Haas GL,Hill J,Weiden PJ

    更新日期:1991-06-01 00:00:00

  • A commingling analysis of platelet monoamine oxidase activity.

    abstract::The distribution of platelet monoamine oxidase (MAO) activity is examined in a large cohort of 18-year-olds from a college setting. A mixture of three distributions is needed to describe the data, even when a power transformation is used to remove skewness in the distribution. This is compatible with MAO activity bein...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Rice J,McGuffin P,Shaskan EG

    更新日期:1982-12-01 00:00:00

  • The correlation between the quality of life and clinical variables among outpatients with schizophrenia.

    abstract::The study identifies the correlation between the quality of life (QoL) among outpatients with schizophrenia and clinical outcomes. A cross-sectional study design was used with 157 people with schizophrenia treated in outpatient clinics. Demographic, clinical and psychosocial variables were examined for their influence...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Hasan AA

    更新日期:2019-01-01 00:00:00

  • Psychotic and nonpsychotic depressions: II. Platelet MAO activity, plasma catecholamines, cortisol, and specific symptoms.

    abstract::Preliminary data are presented on levels of plasma cortisol, dopamine (DA), epinephrine (EPI), and norepinephrine (NE) before and after dexamethasone in 22 depressed patients (of whom 4 were psychotic). Platelet monoamine oxidase (MAO) activity, determined in 19 of the depressed patients, was significantly higher in t...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Schatzberg AF,Rothschild AJ,Langlais PJ,Lerbinger JE,Schildkraut JJ,Cole JO

    更新日期:1987-02-01 00:00:00

  • Cognitive insight in psychosis: the relationship between self-certainty and self-reflection dimensions and neuropsychological measures.

    abstract::Cognitive insight in schizophrenia encompasses the evaluation and reinterpretation of distorted beliefs and appraisals. We investigated the neuropsychological basis of cognitive insight in psychosis. It was predicted that, like clinical insight, cognitive insight would be associated with a wide range of neuropsycholog...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Cooke MA,Peters ER,Fannon D,Aasen I,Kuipers E,Kumari V

    更新日期:2010-07-30 00:00:00

  • Affective temperaments play an important role in the relationship between childhood abuse and depressive symptoms in major depressive disorder.

    abstract::Previous studies have shown that various factors, such as genetic and environmental factors, contribute to the development of major depressive disorder (MDD). The aim of this study is to clarify how multiple factors, including affective temperaments, childhood abuse and adult life events, are involved in the severity ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Toda H,Inoue T,Tsunoda T,Nakai Y,Tanichi M,Tanaka T,Hashimoto N,Takaesu Y,Nakagawa S,Kitaichi Y,Boku S,Tanabe H,Nibuya M,Yoshino A,Kusumi I

    更新日期:2016-02-28 00:00:00

  • A new treatment for children with chronic tic disorders - Resource activation.

    abstract::The aim of this pilot study is to evaluate the efficacy of a resource activation (RA) program as an alternative intervention for children and adolescents with tic disorders. RA interventions focus on the strengths and abilities of the patients. This is expected to improve the patients' perceptions regarding their own ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Viefhaus P,Feldhausen M,Görtz-Dorten A,Volk H,Döpfner M,Woitecki K

    更新日期:2019-03-01 00:00:00

  • Measuring consistency of autobiographical memory recall in depression.

    abstract::Autobiographical amnesia assessments in depression need to account for normal changes in consistency over time, contribution of mood and type of memories measured. We report herein validation studies of the Columbia Autobiographical Memory Interview - Short Form (CAMI-SF), exclusively used in depressed patients receiv...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Semkovska M,Noone M,Carton M,McLoughlin DM

    更新日期:2012-05-15 00:00:00

  • Relationship of birth season to clinical features, family history, and obstetric complication in schizophrenia.

    abstract::Birth in late winter and spring has been consistently shown to be a risk factor of schizophrenia. The relationship of late winter/spring birth to clinical characteristics and other putative risk factors, such as family history and obstetric complications, may provide clues to etiology. Data relating to season of birth...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Dassa D,Sham PC,van Os J,Abel K,Jones P,Murray RM

    更新日期:1996-08-30 00:00:00

  • Neuroimaging of hallucinations: a review of the literature.

    abstract::While hallucinations have been described for over two millennia, their cause remains unclear. Brain-based models suggest that abnormal cerebral excitation and a lack of normal cerebral inhibition may play primary roles, but evaluation of these hypotheses has been hampered by difficulty in studying the hallucinatory st...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审


    authors: Weiss AP,Heckers S

    更新日期:1999-12-20 00:00:00

  • Caudate regional cerebral blood flow in obsessive-compulsive disorder, panic disorder and healthy controls on single photon emission computerised tomography.

    abstract::We compared regional cerebral blood flow (rCBF) in 15 patients with DSM IIIR obsessive-compulsive disorder (OCD), 15 patients with DSM IIIR panic disorder and 15 healthy controls matched for age, sex and hand preference, using uptake of technetium-99m-D,L-hexamethyl-propylene amine oxime (99mTc HMPAO), on single photo...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Lucey JV,Costa DC,Busatto G,Pilowsky LS,Marks IM,Ell PJ,Kerwin RW

    更新日期:1997-03-14 00:00:00

  • The impact of perceived stigma on psychiatric care and outcomes for correctional mental health patients.

    abstract::The purpose of this study was to examine factors related to the delivery and effectiveness of psychiatric care prior to and following prison release. Particular attention was placed on patients' self-reported needs, psychiatric medication adherence, and perceived stigma related to mental health treatment, and how thes...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Farabee D,Hall E,Zaheer A,Joshi V

    更新日期:2019-06-01 00:00:00

  • Endocrine parameters and biogenic amines in relationship to psychopathology after cholinergic drug challenge (RS-86).

    abstract::The centrally active muscarinic agonist RS-86 elicited a dose-dependent anergic-anhedonic syndrome in a double-blind dose-response study in one healthy volunteer. At 4 and 5 mg, RS-86 induced escape from cortisol suppression by dexamethasone parallel to an increase in prolactin. The time course, as well as the absence...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章


    authors: Fritze J,Sofic E,Riederer P,Beckmann H

    更新日期:1988-09-01 00:00:00

  • Illness severity, trait anxiety, cognitive impairment and heart rate variability in bipolar disorder.

    abstract::Numerous studies have documented a significant association between symptom severity and cognitive functioning in bipolar disorder (BD). These findings advanced speculations about a potential link between the physiological stress associated with illness severity and cognitive dysfunction. To explore this hypothesis, th...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Levy B

    更新日期:2014-12-30 00:00:00

  • Impact of major depressive disorder, distinct subtypes, and symptom severity on lifestyle in the BiDirect Study.

    abstract::The aim of this study was to examine associations of major depressive disorder (MDD), its distinct subtypes, and symptom severity with the individual lifestyle factors smoking, diet quality, physical activity, and body mass index as well as with a combined lifestyle index measuring the co-occurrence of these lifestyle...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Rahe C,Khil L,Wellmann J,Baune BT,Arolt V,Berger K

    更新日期:2016-11-30 00:00:00

  • A multivariate approach to aggression and the orbital frontal cortex in psychiatric patients.

    abstract::The association between orbital frontal cortex (OFC) volume and aggression was investigated in an at-risk psychiatric population. Forty-one psychiatric patients were referred for magnetic resonance imaging and a standardized psychometric assessment of aggression (Lifetime History of Aggression-Revised). Nineteen match...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Gansler DA,McLaughlin NC,Iguchi L,Jerram M,Moore DW,Bhadelia R,Fulwiler C

    更新日期:2009-03-31 00:00:00

  • Gambling onset and progression in a sample of at-risk gamblers from the general population.

    abstract::The goal of this study was to investigate gambling-related behavior, onset and progression in a sample of at-risk gamblers from the community. A national household survey was conducted in Brazil, covering individuals 14 years old or older. Subjects were screened for at-risk gambling, those testing positive answered a ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Carneiro E,Tavares H,Sanches M,Pinsky I,Caetano R,Zaleski M,Laranjeira R

    更新日期:2014-05-30 00:00:00

  • No elevated D2 dopamine receptors in neuroleptic-naive schizophrenic patients revealed by positron emission tomography and [11C]N-methylspiperone.

    abstract::The dopamine hypothesis of schizophrenia received strong support when a two- to three-fold elevation of D2 receptor densities was demonstrated by positron emission tomography (PET) and [11C]N-methylspiperone ([11C]NMSP). In the present study, the reproducibility of this finding was examined by application of a similar...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Nordström AL,Farde L,Eriksson L,Halldin C

    更新日期:1995-08-08 00:00:00

  • Searching for a structural endophenotype in psychosis using computational morphometry.

    abstract::Structural cerebral abnormalities are frequently observed in schizophrenia. These abnormalities may indicate vulnerability for the disorder, as evidenced by reports of familial clustering of measures identified through region-of-interest analyses using manual outlining procedures. We used computational morphometry to ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Marcelis M,Suckling J,Woodruff P,Hofman P,Bullmore E,van Os J

    更新日期:2003-04-01 00:00:00

  • The association of MHPG to dexamethasone suppression test status.

    abstract::The results of the dexamethasone suppression test (DST) were compared to levels of 24-hour 3-methoxy-4-hydroxyphenylglycol (MHPG) in 60 patients with unipolar depression. DST nonsuppressors had significantly higher levels of MHPG than did DST suppressors. The possible implications of this finding are discussed. ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Garvey MJ,Hollon S,Evans M,DeRubeis RJ,Tuason VB

    更新日期:1988-05-01 00:00:00

  • Neuroticism and quality of life: Multiple mediating effects of smartphone addiction and depression.

    abstract::The purposes of this study were to investigate the mediating effect of smartphone addiction and depression on neuroticism and quality of life. Self-reported measures of neuroticism, smart-phone addiction, depression, and quality of life were administered to 722 Chinese university students. Results showed smartphone ad...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Gao T,Xiang YT,Zhang H,Zhang Z,Mei S

    更新日期:2017-12-01 00:00:00

  • Affect processing and positive syndrome schizotypy in cannabis users.

    abstract::While cannabis is associated with positive syndrome schizophrenia (SZ), it is unclear whether cannabinoids are also related to negative symptoms such as affective blunting. We examined whether cannabis use is associated with schizotypy and utilized event-related potentials (ERPs) to assess affect processing. Cannabis ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Skosnik PD,Park S,Dobbs L,Gardner WL

    更新日期:2008-01-15 00:00:00

  • Gating of auditory evoked responses in normal college students.

    abstract::Several neurophysiological indicators of abnormal sensory processing found in psychosis are also found in lower incidence in normal populations, particularly those at the age of risk for illness. One such parameter, gating of the auditory evoked potential, was evaluated in college students. Auditory stimuli were prese...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Waldo MC,Freedman R

    更新日期:1986-11-01 00:00:00

  • Preliminary findings of proton magnetic resonance spectroscopy in occipital cortex during sleep deprivation.

    abstract::Proton magnetic resonance spectroscopy ((1)H MRS) has revealed biochemical alterations in various psychiatric disorders. Changes in brain metabolites may be caused not only by the disease's progression or response to treatment, but also by physiological variability. The aim of this study was to use (1)H MRS to assess ...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Urrila AS,Hakkarainen A,Heikkinen S,Huhdankoski O,Kuusi T,Stenberg D,Häkkinen AM,Porkka-Heiskanen T,Lundbom N

    更新日期:2006-06-30 00:00:00

  • Investigation of automatic avoidance in displaced individuals with chronic Posttraumatic Stress Disorder (PTSD).

    abstract::Avoidance of trauma-related stimuli is a key feature of Posttraumatic Stress Disorder (PTSD). However, avoidance has almost exclusively been investigated with explicit measures targeting more strategic aspects of behavior. The aim of the present study was to examine automatic avoidance in older individuals displaced a...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Wittekind CE,Behmer F,Muhtz C,Fritzsche A,Moritz S,Jelinek L

    更新日期:2015-08-30 00:00:00

  • Associations between neuropsychiatric and health status outcomes in individuals with probable mTBI.

    abstract::Mild traumatic brain injury (mTBI) is a common occurrence, and may impact distal outcomes in a subgroup of individuals. Improved characterization of health outcomes and identification of factors associated with poor outcomes is needed to better understand the impact of mTBI, particularly in those with co-occurring pos...

    journal_title:Psychiatry research

    pub_type: 杂志文章


    authors: Bomyea J,Flashman LA,Zafonte R,Andaluz N,Coimbra R,George MS,Grant GA,Marx CE,McAllister TW,Shutter L,Lang AJ,Stein MB

    更新日期:2019-02-01 00:00:00