Abstract：
:Despite the widespread abuse of marijuana, knowledge about its effects in the human brain is limited. Brain glucose metabolism with and without delta 9 tetrahydrocannabinol (THC) (main psychoactive component of marijuana) was evaluated in eight normal subjects and eight chronic marijuana abusers with positron emission tomography. At baseline, marijuana abusers showed lower relative cerebellar metabolism than normal subjects. THC increased relative cerebellar metabolism in all subjects, but only abusers showed increases in orbitofrontal cortex, prefrontal cortex, and basal ganglia. Cerebellar metabolism during THC intoxication was significantly correlated with the subjective sense of intoxication. The decreased cerebellar metabolism in marijuana abusers at baseline could account for the motor deficits previously reported in these subjects. The activation of orbitofrontal cortex and basal ganglia by THC in the abusers but not in the normal subjects could underlie one of the mechanisms leading to the drive and the compulsion to self-administer the drug observed in addicted individuals.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Volkow ND,Gillespie H,Mullani N,Tancredi L,Grant C,Valentine A,Hollister Ldoi
10.1016/0925-4927(96)02817-xsubject
Has Abstractpub_date
1996-05-31 00:00:00pages
29-38issue
1eissn
0165-1781issn
1872-7123journal_volume
67pub_type
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