Abstract：
:The current study aimed to prove the antidepressant-like effects and the probable mechanisms of Schisandrin on depression, which induced by chronic unpredictable mild stress (CUMS) in mice. Four weeks of CUMS exposure resulted in depressive-like behavior, as indicated by the significant decrease in sucrose consumption and increase the immobility time in the forced swim test, but without any influence on the locomotor activity. Further, there were significant downregulations of GDNF/ERK1/2/ROS and PI3K/AKT/NOX signaling pathways in the hippocampus and prefrontal cortex in depressed mice. Treatment of mice with Schisandrin (30mg/kg) and Fluoxetine (10mg/kg) significantly ameliorated all the behavioral and biochemical changes induced by CUMS. These results suggest that Schisandrin produces an antidepressant-like effect in CUMS-induced mice, which possibly mediated, at least in part, by rectifying the signaling pathways of GDNF/ERK1/2/ROS and PI3K/AKT/NOX.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Wan S,Xu M,Hu L,Yan T,He B,Xiao F,Bi K,Jia Ydoi
10.1016/j.psychres.2017.07.081subject
Has Abstractpub_date
2017-11-01 00:00:00pages
230-237eissn
0165-1781issn
1872-7123pii
S0165-1781(17)30631-5journal_volume
257pub_type
杂志文章abstract：:Impairments in emotion recognition skills are a trans-diagnostic indicator of early mental health problems and may be responsive to intervention. We report on a randomized controlled trial of "Emotion-recognition-training" (ERT) versus treatment-as-usual (TAU) with N=195 mixed diagnostic children (mean age 10.52 years...
journal_title：Psychiatry research
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pub_type： 杂志文章
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