Abstract：
:Numerous evidence indicated mitochondrial abnormalities in the pathophysiology of bipolar disorder (BD); however, it remains unclear whether aberrant mitochondrial DNA (mtDNA) copy number (cn) occur in BD due to the conflicting results in previous studies. Here, peripheral blood mtDNAcn in 69 BD patients and 54 controls were analysed via qPCR. BD patients had significantly lower mtDNAcn compared to controls (regardless of their BD type [BD I or II]). Meta-analysis for all previous BD-mtDNAcn studies combining our results with previously published studies failed to identify any significant association. Meanwhile, Asian-specific meta-analysis remarkably revealed lower mtDNAcn in BD patients.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Yamaki N,Otsuka I,Numata S,Yanagi M,Mouri K,Okazaki S,Boku S,Horai T,Ohmori T,Shirakawa O,Sora I,Hishimoto Adoi
10.1016/j.psychres.2018.08.014subject
Has Abstractpub_date
2018-11-01 00:00:00pages
115-117eissn
0165-1781issn
1872-7123pii
S0165-1781(18)30593-6journal_volume
269pub_type
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