Abnormal regional homogeneity in young adult suicide attempters with no diagnosable psychiatric disorder: a resting state functional magnetic imaging study.

Abstract:

:Many young adults who attempt suicide have no discernible mental illness, suggesting an etiology distinct from other psychiatric disorders. Neurological anomalies associated with a history of suicidal behavior may predict future risk. In the present study, we explored changes in neural circuit organization associated with suicidal behavior by comparing local synchronization of resting-state functional magnetic resonance imaging signals in suicide attempters without a psychiatric diagnosis (SA group, 19.84±1.61 years, n=19) with those in healthy controls (HC group, 20.30±1.72 years, n=20) using regional homogeneity (ReHo) analysis. The SA group exhibited significantly lower mean ReHo in the left (L) fusiform and supraorbital inferior frontal gyri, L hippocampus, bilateral parahippocampal and middle frontal gyri, right (R) angular gyrus, and cerebellar lobules RVIII, RII, and LVI compared with the HC group. Conversely, in the SA group, ReHo was higher in the R supraorbital middle frontal gyrus, R inferior parietal lobe, and L precuneus. The SA group also had significantly higher total Barratt Impulsiveness Scale scores compared with the HC group. Local functional connectivity is altered in multiple regions of the cerebral cortex, limbic system, and cerebellum of suicidal young adults. Elucidating the functional deficits associated with these ReHo changes may clarify the pathophysiological mechanisms of suicidal behavior and assist in identifying high-risk individuals.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Cao J,Chen JM,Kuang L,Ai M,Fang WD,Gan Y,Wang W,Chen XR,Xu XM,Wang HG,Lv Z

doi

10.1016/j.pscychresns.2014.10.011

subject

Has Abstract

pub_date

2015-02-28 00:00:00

pages

95-102

issue

2

eissn

0165-1781

issn

1872-7123

pii

S0925-4927(14)00263-7

journal_volume

231

pub_type

杂志文章
  • Suicidal ideation during the COVID-19 pandemic: The role of insomnia.

    abstract::There is growing concern over the potential for increased suicide risk in vulnerable populations as the COVID-19 pandemic unfolds. To contextualize this risk during the first weeks of the nationwide lockdown efforts, we had 1,013 U.S. adults complete questionnaires assessing worries over COVID-19, insomnia severity, a...

    journal_title:Psychiatry research

    pub_type: 信件

    doi:10.1016/j.psychres.2020.113134

    authors: Killgore WDS,Cloonan SA,Taylor EC,Fernandez F,Grandner MA,Dailey NS

    更新日期:2020-08-01 00:00:00

  • The use of narrative sampling in the assessment of social cognition: the Narrative of Emotions Task (NET).

    abstract::Social cognitive deficits in schizophrenia are well documented and related to functional outcome. Current social cognition measures are often not psychometrically validated, too heterogeneous for standardization, and focus principally on one domain of social cognition rather than the simultaneous activation of multipl...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2014.03.014

    authors: Buck B,Ludwig K,Meyer PS,Penn DL

    更新日期:2014-07-30 00:00:00

  • Predictors of functional improvement in children and adolescents at a publicly funded specialist outpatient treatment clinic in a Canadian Prairie City.

    abstract::Children's mental health problems substantially impact their functioning. For clinically treated children and adolescents, we explored the impact of mental health treatment on functioning and identified predictors of functional improvement. Outpatient clinical data from a regional publicly funded specialist outpatient...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2019.01.093

    authors: Li M,D'Arcy C,Meng X

    更新日期:2019-03-01 00:00:00

  • Regional cerebral blood flow in long-term heavy cannabis use.

    abstract::Regional cerebral blood flow (rCBF) was measured by the 133Xenon inhalation method in nine male chronic cannabis users. The rCBF level in cannabis users was significantly (11%) lower than that of age- and sex-matched healthy controls. Four of the subjects were reexamined after 9-60 days of detoxification and showed a ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(86)90037-5

    authors: Tunving K,Thulin SO,Risberg J,Warkentin S

    更新日期:1986-01-01 00:00:00

  • Child loss and psychosis onset: evidence for traumatic experience as an etiological factor in psychosis.

    abstract::Previous research suggests that trauma may contribute to psychosis onset. In this study, we examine the effect of parental loss of a child on the onset of psychotic experience using data from the National Comorbidity Survey Replication, hypothesizing that child loss will precede the onset of psychosis and will be asso...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2012.08.008

    authors: Devylder JE,Wang JS,Oh HY,Lukens EP

    更新日期:2013-01-30 00:00:00

  • Medial frontal gyrus alterations in schizophrenia: relationship with duration of illness and executive dysfunction.

    abstract::Executive functioning is consistently impaired in schizophrenia, and it has been associated with reduced gray matter volume in prefrontal areas. Abnormalities in prefrontal brain regions have also been related to the illness duration. The aim of the study was to investigate the effect of executive functioning decline ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.pscychresns.2014.10.017

    authors: Frascarelli M,Tognin S,Mirigliani A,Parente F,Buzzanca A,Torti MC,Tinelli E,Caramia F,Di Fabio F,Biondi M,Fusar-Poli P

    更新日期:2015-02-28 00:00:00

  • Transdiagnostic neuroimaging in psychiatry: A review.

    abstract::Transdiagnostic approach has a long history in neuroimaging, predating its recent ascendance as a paradigm for new psychiatric nosology. Various psychiatric disorders have been compared for commonalities and differences in neuroanatomical features and activation patterns, with different aims and rationales. This revie...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审

    doi:10.1016/j.psychres.2019.01.026

    authors: Mitelman SA

    更新日期:2019-07-01 00:00:00

  • An effective psychological intervention in reducing internalized stigma and improving recovery outcomes in people with severe mental illness.

    abstract::Internalized stigma reduces chances of clinical and subjective recovery in people with schizophrenia and other severe mental illness. To date, there is not enough evidence about an effective intervention to reduce internalized stigma that promotes clinical and subjective recovery in people with high internalized stigm...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2020.113635

    authors: Díaz-Mandado O,Periáñez JA

    更新日期:2021-01-01 00:00:00

  • Examination of trait impulsivity on the response to a brief mindfulness intervention among college student drinkers.

    abstract::Mindfulness-based strategies show promise for targeting the construct of impulsivity and associated variables among problematic alcohol users. This study examined the moderating role of intervention (mindfulness vs relaxation vs control) on trait impulsivity and three outcomes examined post-intervention (negative affe...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2016.04.115

    authors: Vinci C,Peltier M,Waldo K,Kinsaul J,Shah S,Coffey SF,Copeland AL

    更新日期:2016-08-30 00:00:00

  • Forty years of editorship of psychiatry research.

    abstract::The astonishing 20 fold growth of the yearly published psychiatric research literature over the past four decades has been paralleled and facilitated by the internet application of electronic publishing. This personal history highlights the decade by decade 1978-2018 augmentation and erosion of this interelationship f...

    journal_title:Psychiatry research

    pub_type: 历史文章,杂志文章

    doi:10.1016/j.psychres.2019.01.071

    authors: Buchsbaum MS

    更新日期:2019-07-01 00:00:00

  • Temporal trends of co-diagnosis of depression and/or anxiety among female maternal and non-maternal hospitalizations: Results from Nationwide Inpatient Sample 2004-2013.

    abstract::Perinatal depression/anxiety is considered the most underdiagnosed pregnancy complication in the US and is associated with poor maternal and fetal outcomes. However, despite its prevalence, most women who present with depressive symptoms are not screened and do not receive adequate treatment. We examined the clinical ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2018.12.077

    authors: Pino EC,Zuo Y,Schor SH,Zatwarnicki S,Henderson DC,Borba CP,Milanovic SM,Kalesan B

    更新日期:2019-02-01 00:00:00

  • Characterizing the normative profile of 18F-FDG PET brain imaging: sex difference, aging effect, and cognitive reserve.

    abstract::The aim of this study was to investigate findings of positron emission tomography with 18F-fluorodeoxyglucose (18F-FDG PET) in normal subjects to clarify the effects of sex differences, aging, and cognitive reserve on cerebral glucose metabolism. Participants comprised 123 normal adults who underwent 18F-FDG PET and a...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.pscychresns.2013.10.009

    authors: Yoshizawa H,Gazes Y,Stern Y,Miyata Y,Uchiyama S

    更新日期:2014-01-30 00:00:00

  • Need for closure and cognitive flexibility in individuals with autism spectrum disorder: A preliminary study.

    abstract::The need for closure (NFC), a desire for a firm answer and less ambiguity, has a key role in cognitive flexibility in typical development (TD) populations. This study investigated this motivational construct and its relation to cognitive inflexibility in autism spectrum disorder (ASD). Compared with individuals with T...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2018.11.057

    authors: Fujino J,Tei S,Itahashi T,Aoki Y,Ohta H,Kubota M,Isobe M,Hashimoto RI,Nakamura M,Kato N,Takahashi H

    更新日期:2019-01-01 00:00:00

  • Preliminary effects of bupropion and the promoter region (HTTLPR) serotonin transporter (SLC6A4) polymorphism on smoking behavior in schizophrenia.

    abstract::In the current study, we investigated how individual variants in the serotonin promoter gene, previously associated with smoking cessation and linked to anxiety-related personality traits, were associated with individual differences in responsiveness to bupropion and cognitive behavioral therapy (CBT) in a clinical po...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.psychres.2008.12.015

    authors: Bloch B,Reshef A,Cohen T,Tafla A,Gathas S,Israel S,Gritsenko I,Kremer I,Ebstein RP

    更新日期:2010-01-30 00:00:00

  • Quality of life after housing first for adults with serious mental illness who have experienced chronic homelessness.

    abstract::This 1-year longitudinal study of adults who have recently transitioned from homelessness to Permanent Supportive Housing (PSH) focuses on quality of life as a primary outcome of interest. Eighty of 103 new tenants participated in structured interviews at the time of entry into their new home and at 12-months post-hou...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2014.07.072

    authors: Henwood BF,Matejkowski J,Stefancic A,Lukens JM

    更新日期:2014-12-15 00:00:00

  • CSF kynurenic acid and suicide risk in schizophrenia spectrum psychosis.

    abstract::Relationships between concentrations of cerebrospinal fluid (CSF) kynurenic acid (KYNA) and suicidal behavior were evaluated in 59 patients with psychosis after 22 years of follow-up. Three patients died from suicide and nine patients had a history of attempted suicide. Patients with attempted suicide had significantl...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2012.08.021

    authors: Carlborg A,Jokinen J,Jönsson EG,Erhardt S,Nordström P

    更新日期:2013-01-30 00:00:00

  • Effects of sleep deprivation on depressed patients of different nosological groups.

    abstract::In a study of 80 patients who received 164 treatments with sleep deprivation, the following questions were addressed: Do depressive patients of different subgroups respond differently to sleep deprivation? what complications arise? does the same patient react in the same way to multiple treatments? are there differenc...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(81)90074-3

    authors: Fähndrich E

    更新日期:1981-12-01 00:00:00

  • Serotonin 1A receptor gene, schizophrenia and bipolar disorder: an association study and meta-analysis.

    abstract::Several investigations have reported associations between serotonin 1A (5-HT1A) receptor and major psychiatric disorders, such as schizophrenia and bipolar disorder (BP), making the 5-HT1A receptor gene (HTR1A) a good candidate gene for the pathophysiology of schizophrenia and BP. To evaluate the association between H...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2010.06.003

    authors: Kishi T,Okochi T,Tsunoka T,Okumura T,Kitajima T,Kawashima K,Yamanouchi Y,Kinoshita Y,Naitoh H,Inada T,Kunugi H,Kato T,Yoshikawa T,Ujike H,Ozaki N,Iwata N

    更新日期:2011-01-30 00:00:00

  • Low brain serotonin transporter binding in major depressive disorder.

    abstract::We examined midbrain, medial temporal lobe, and basal ganglia serotonin transporter (SERT) distribution volume ratio (DVR) values in subjects with major depressive disorder versus healthy volunteers using a selective SERT radioligand and single photon emission computed tomography (SPECT). We hypothesized that the DVR ...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.pscychresns.2011.12.015

    authors: Newberg AB,Amsterdam JD,Wintering N,Shults J

    更新日期:2012-05-31 00:00:00

  • Insecure attachment as a factor in hoarding behaviors in a non-clinical sample of women.

    abstract::Hoarding is linked to ambivalence and uncertainty about one's self and others. These notions are close to those constituting attachment representations. Hoarding is also linked to seeking support from objects. Studies concerning attachment and hoarding suggest that attachment representations may impact seeking or poss...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2018.09.053

    authors: Danet M,Secouet D

    更新日期:2018-12-01 00:00:00

  • Dealing with feeling: Specific emotion regulation skills predict responses to stress in psychosis.

    abstract::Elevated negative affect is an established link between minor stressors and psychotic symptoms. Less clear is why people with psychosis fail to regulate distressing emotions effectively. This study tests whether subjective, psychophysiological and symptomatic responses to stress can be predicted by specific emotion re...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2015.04.003

    authors: Lincoln TM,Hartmann M,Köther U,Moritz S

    更新日期:2015-08-15 00:00:00

  • Wisconsin Card Sorting Test performance in obsessive-compulsive disorder: no evidence for involvement of dorsolateral prefrontal cortex.

    abstract::Wisconsin Card Sorting Test (WCST) performances were studied in 33 patients with obsessive-compulsive disorder (OCD) and 33 age-, sex-, and education-matched normal comparison subjects; the OCD patients were divided into four subgroups on the basis of their symptomatology. Neither the two groups of subjects nor the fo...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/0165-1781(95)02670-r

    authors: Abbruzzese M,Ferri S,Scarone S

    更新日期:1995-09-08 00:00:00

  • Hippocampal FXR plays a role in the pathogenesis of depression: A preliminary study based on lentiviral gene modulation.

    abstract::As a well-known bile acid receptor, the role of Farnesoid X receptor (FXR) in the digestive system and cardiovascular system has been widely explored. However, there are very few studies involving FXR in the central nervous system. In this study, we explored the role of FXR in the pathogenesis of depression, a serious...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2018.04.025

    authors: Chen WG,Zheng JX,Xu X,Hu YM,Ma YM

    更新日期:2018-06-01 00:00:00

  • Compulsive sexual behavior and psychopathology among treatment-seeking men in São Paulo, Brazil.

    abstract::This study examined compulsive sexual behavior (CSB) and psychopathology in a treatment-seeking sample of men in São Paulo, Brazil. Eighty-six men (26% gay, 17% bisexual, 57% heterosexual) who met diagnostic criteria for excessive sexual drive and sexual addiction completed assessments consisting of the Mini Internati...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2013.01.021

    authors: Scanavino Mde T,Ventuneac A,Abdo CH,Tavares H,do Amaral ML,Messina B,dos Reis SC,Martins JP,Parsons JT

    更新日期:2013-10-30 00:00:00

  • Visual evoked potentials as a predictor of reported side effects during a trial of zimelidine vs. placebo in chronic pain patients.

    abstract::Before a double-blind controlled study of zimelidine, a new, rather specific inhibitor of serotonin uptake, in patients with chronic pain, visual evoked potentials (EPs) to stimuli of varying intensities were recorded. During the trial the blood levels of zimelidine and its active metabolite norzimelidine were estimat...

    journal_title:Psychiatry research

    pub_type: 临床试验,杂志文章

    doi:10.1016/0165-1781(79)90003-9

    authors: von Knorring L,Johansson F

    更新日期:1979-12-01 00:00:00

  • Assessing illicit drug use among adults with schizophrenia.

    abstract::Accurate drug use assessment is vital to understanding the prevalence, course, treatment needs, and outcomes among individuals with schizophrenia because they are thought to remain at long-term risk for negative drug use outcomes, even in the absence of drug use disorder. This study evaluated self-report and biologica...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2012.05.028

    authors: Van Dorn RA,Desmarais SL,Scott Young M,Sellers BG,Swartz MS

    更新日期:2012-12-30 00:00:00

  • Do cognitive measures of response inhibition differentiate between attention deficit/hyperactivity disorder and borderline personality disorder?

    abstract::This study examined whether cognitive measures of response inhibition derived from the AX-CPT are able to differentiate between adult attention deficit/hyperactivity disorder (ADHD), borderline personality disorder (BPD), and healthy controls (HC). Current DSM-IV-TR symptoms of ADHD and BPD were assessed by structured...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2013.12.034

    authors: van Dijk F,Schellekens A,van den Broek P,Kan C,Verkes RJ,Buitelaar J

    更新日期:2014-03-30 00:00:00

  • Pattern-reversed visual evoked potentials in subtypes of major depression.

    abstract::There are no articles in the international psychiatric literature reporting subclinical visual system disorders in depressed patients, although a disturbance of circadian rhythms is one of the prominent theories of the etiopathogenesis of depression. Fifty patients aged 21-60 years suffering from major depression acco...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/s0165-1781(03)00097-0

    authors: Fotiou F,Fountoulakis KN,Iacovides A,Kaprinis G

    更新日期:2003-06-15 00:00:00

  • Neuropsychological performance and affective temperaments in Euthymic patients with bipolar disorder type II.

    abstract::Affective temperament has been suggested as a potential mediator of the effect between genetic predisposition and neurocognitive functioning. As such, this report seeks to assess the extent of the correlation between affective temperament and cognitive function in a group of bipolar II subjects. 46 bipolar II outpatie...

    journal_title:Psychiatry research

    pub_type: 杂志文章

    doi:10.1016/j.psychres.2016.02.032

    authors: Romero E,Holtzman JN,Tannenhaus L,Monchablon R,Rago CM,Lolich M,Vázquez GH

    更新日期:2016-04-30 00:00:00

  • The relationship between impulse-control disorders and obsessive-compulsive disorder: a current understanding and future research directions.

    abstract::Impulse-control disorders (ICDs) constitute a heterogeneous group of conditions linked diagnostically by difficulties in resisting "the impulse, drive, or temptation to perform an act that is harmful to the person or to others." Specific ICDs share clinical, phenomenological and biological features with obsessive-comp...

    journal_title:Psychiatry research

    pub_type: 杂志文章,评审

    doi:10.1016/j.psychres.2008.06.036

    authors: Potenza MN,Koran LM,Pallanti S

    更新日期:2009-11-30 00:00:00