Abstract：
:A molecular pathway analysis has been performed in order to complement previous genetic investigations on Schizophrenia. 4486 Schizophrenic patients and 4477 controls served as the investigation sample. 3521 Bipolar patients and 3195 controls served as replication sample. A molecular pathway associated with the neuronal pruning activity was found to be enriched in subjects with Schizophrenia compared to controls. HLA-C and HLA-DRA had more SNPs associated with both Schizophrenia and Bipolar Disorder than expected by chance.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Calabrò M,Drago A,Sidoti A,Serretti A,Crisafulli Cdoi
10.1016/j.psychres.2015.06.013subject
Has Abstractpub_date
2015-08-30 00:00:00pages
945-9issue
3eissn
0165-1781issn
1872-7123pii
S0165-1781(15)00359-5journal_volume
228pub_type
杂志文章abstract：:Treatment for depression is not effective in all patients and it is therefore important to identify factors that can be used to tailor treatments. One potential factor is insomnia. Several repetitive transcranial magnetic stimulation (rTMS) studies have reported on this symptom, however, they did not take into account...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/j.psychres.2013.04.028
更新日期：2013-11-30 00:00:00
abstract：:Human corticotropin releasing hormone (h-CRH) was administered to 14 patients with major depression, after premedication with an overnight dose of 1.5 mg dexamethasone. Cortisol response, expressed as area under the time course curve (AUC), was significantly higher in the 14 patients than in a group of 13 age-matched ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(91)90041-m
更新日期：1991-08-01 00:00:00
abstract：:In Vietnam, stigmatisation and discrimination of patients with mental illness are highly prevalent. This study explores whether the perception of course of illness of people with symptoms indicating schizophrenia is associated with the desire for social distance in the Vietnamese public. A population-based survey (n =...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.05.046
更新日期：2018-10-01 00:00:00
abstract：:In the present study we set out to explore the long-term clinical course of schizophrenia in a holistic manner by adopting sequence analysis. Our aim was to identify course types of illness by means of cluster analysis. The study was based on course and outcome data for 107 patients followed up over 134 months after f...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.04.056
更新日期：2015-08-30 00:00:00
abstract：:The primary objective of our study was to investigate both the negative and positive psychological changes following the Lushan earthquake, and to explore the factors associated with psychological changes. Multi-stage random sampling was used to select respondents from Lushan County, Sichuan Province, China. A simplif...
journal_title：Psychiatry research
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.psychres.2014.07.050
更新日期：2014-12-15 00:00:00
abstract：:If dissociative symptoms are manifestations of a psychological defense mechanism, one would expect people who have such symptoms to react with lower levels of physiological arousal and with memory omissions to emotionally provocative material. The current study tested this assumption in a sample of undergraduates. Six...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.04.016
更新日期：2007-04-15 00:00:00
abstract：:Persons with schizophrenia and schizoaffective disorder exhibit deficits in both visual processing and neuropsychological tasks. Little is known, however, about whether these deficits are related to one another. We administered psychophysical tests of visual discrimination and recognition, and neuropsychological tests...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(02)00139-7
更新日期：2002-08-30 00:00:00
abstract：:This study assessed the subjective and cardiovascular effects of relevant doses of cocaine administration during steady-state treatment of the combination of amantadine and baclofen compared to placebo. Participants included 8 healthy, male, cocaine-dependent, non-treatment-seeking individuals (age=36.6+/-5.9; 75% Afr...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.03.012
更新日期：2007-08-30 00:00:00
abstract：:There is a clinical need for objective evidence-based measures that are sensitive and specific to ADHD when compared with other neurodevelopmental disorders. This study evaluated the incremental validity of adding an objective measure of activity and computerised cognitive assessment to clinical rating scales to diffe...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.06.042
更新日期：2016-09-30 00:00:00
abstract：:This study explores the psychometric characteristics of the Behavior Problems Inventory (BPI), an instrument for routine clinical assessment of behavior problems in outpatients with psychosis based on information provided by key family informants. Six hundred and twenty-one patients diagnosed with psychosis and bipola...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.03.051
更新日期：2018-12-01 00:00:00
abstract：:One of the central problems in posttraumatic stress disorder (PTSD) is the inability to suppress fear even under safe conditions. The neural underpinnings of fear are clinically relevant but poorly understood. This study assessed fear potentiation and fear inhibition using fear-potentiated startle in a conditional dis...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2007.12.014
更新日期：2009-05-15 00:00:00
abstract：:Increased levels of antibodies to gliadin, which is derived from the wheat protein gluten, have been reported in schizophrenia and bipolar disorder in cross-sectional studies. We examined longitudinally the levels of antibody reactivity to gliadin in acute mania. The sample included 60 individuals assessed during a ho...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.11.007
更新日期：2012-03-30 00:00:00
abstract：:Despite heritability estimates of 37-69%, research has identified few genetic risk variants for borderline personality disorder (BPD). The present collaborative candidate gene study of 987 BPD cases and 1110 healthy controls found an association between BPD and single nucleotide polymorphism rs12718541 in the dopa dec...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.06.031
更新日期：2014-11-30 00:00:00
abstract：:Social anxiety disorder symptoms are generally proposed to be related to broad temperamental vulnerabilities (e.g., a low level of approach and high level of avoidance temperament), specific psychological vulnerabilities (e.g., fears of negative and positive evaluation), and additional disorders (e.g., major depressiv...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.01.073
更新日期：2017-04-01 00:00:00
abstract：:Catechol-O-methyltransferase (COMT) is a candidate gene for the pathogenesis of some psychiatric disorders. The aim of this study is to examine the role of the COMT gene Val158Met polymorphism on the clinical aspects of bipolar disorder including symptomatology and therapeutic response. This study comprised 144 unrela...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.psychres.2008.09.011
更新日期：2010-01-30 00:00:00
abstract：:The limbic system plays an important role in regulating the hypothalamic-pituitary-adrenal (HPA) axis as well as aspects of emotion, and both neuroendocrine disturbance and increased negative emotionality are associated with risk for developing affective disorders. However, the extent to which the architecture of conn...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2011.07.015
更新日期：2012-01-30 00:00:00
abstract：:In schizophrenia, psychomotor slowing and stereotypy are poorly delineated from cognitive deficits like diminished processing speed. Inpatients' performance outcomes on a line-copying task, a task assessing stereotypy and a processing-speed task are compared. Results suggested that psychomotor slowing and stereotypy a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.01.017
更新日期：2008-10-30 00:00:00
abstract：:In a review of the current literature, we identified (1)H MRS studies of major depressive disorder (MDD) that examined the metabolites N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), glutamate/glutamine/gamma-aminobutyric acid-GABA (Glx), and creatine (Cr). Separate meta-analyses comparing adult and pediatr...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.pscychresns.2005.12.004
更新日期：2006-06-30 00:00:00
abstract：:Numerous studies have implicated a connection between schizophrenia and autoimmune disorders. However, the precise relationship and underlying mechanism are still obscure. To further identify the association between autoimmune disorders and schizophrenia, the mRNA expressions of various cytokines and Toll-like recepto...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.04.049
更新日期：2011-05-30 00:00:00
abstract：:Most people with a serious mental illness experience significant functional impairment despite ongoing pharmacological treatment. Thus, in order to improve outcomes, a better understanding of functional predictors is needed. This study examined negative affect, a construct comprised of negative emotional experience, a...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.06.031
更新日期：2016-09-30 00:00:00
abstract：:Anxiety in young adults has recently been linked to reduced capacities to inhibit the processing of non-affective perceptual distractors. However, no previous research has addressed the relationship between social anxiety disorder (SAD) and the ability to intentionally inhibit no longer relevant memories. In an experi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.09.027
更新日期：2013-07-30 00:00:00
abstract：:Sparse evidence of a co-aggregation of the risk of schizophrenia and bipolar disorder provides support for a shared but nonspecific genetic etiology of bipolar disorder and schizophrenia. Temperaments are conceptualized as trait sub-syndromic conditions of major pathologies. This study set out to test the hypothesis o...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.10.027
更新日期：2015-01-30 00:00:00
abstract：:Cognitive deficits have been found to be more prevalent in psychotic than in other disorders. Longitudinal research has shown that these deficits were generally already existent before onset of illness and are therefore not necessarily attributable to neurodegenerative processes. This study investigated whether both l...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.05.035
更新日期：2013-11-30 00:00:00
abstract：:Hippocampus and amygdala volumes in posttraumatic stress disorder (PTSD) related to childhood trauma are relatively understudied, albeit the potential importance to the disorder. Whereas some studies reported smaller hippocampal volumes, little evidence was found for abnormal amygdala volumes. Here we investigated hip...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2015.07.016
更新日期：2015-09-30 00:00:00
abstract：:Obese people׳s distortions in visually-based mental body-parts representations have been reported in previous studies, but other sensory modalities have largely been neglected. In the present study, we investigated possible differences in tactilely-based body-parts representation between an obese and a healthy-weight ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.08.020
更新日期：2014-12-30 00:00:00
abstract：:Olfactory identification ability implicates the integrity of the orbitofrontal cortex (OFC). The fronto-striatal circuits including the OFC have been involved in the neuropathology of Obsessive Compulsive Disorder (OCD). However, only a few studies have examined olfactory function in patients with OCD. The Brief Smell...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.05.032
更新日期：2013-11-30 00:00:00
abstract：:Social cognition is impaired in schizophrenia, is relatively independent of purely neurocognitive domains such as attention and executive functioning, and may be the strongest predictor of functional outcome in this disease. Within a motivated reasoning framework, we tested the hypothesis that the anti-inflammatory Th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.02.030
更新日期：2017-05-01 00:00:00
abstract：:Low plasma total testosterone (T) levels may influence the sense of well-being and produce depressive symptomatology, increasing the risk of suicide. In a previous study, we reported reduced serum T levels in male psychiatric patients after a suicide attempt. The reduction was more pronounced in subjects who used viol...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.08.001
更新日期：2009-11-30 00:00:00
abstract：:To date, there has been limited investigation identifying predictors of deliberate self-harm (DSH) among sexual minority adults. The present study examined the likelihood of DSH by sexual minority status as measured by self-reported sexual identity and sexual attraction in the National Epidemiologic Survey on Alcohol ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.112863
更新日期：2020-02-10 00:00:00
abstract：:A widespread assumption in research and clinical practice is that cognitive reappraisal is a healthy and successful emotion regulation strategy, while expressive suppression is ineffective and has non-favourable consequences (e.g., decreased positive affect, higher physiological arousal). However, little is known abou...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.05.034
更新日期：2012-12-30 00:00:00
