Abstract：
:This study assessed the subjective and cardiovascular effects of relevant doses of cocaine administration during steady-state treatment of the combination of amantadine and baclofen compared to placebo. Participants included 8 healthy, male, cocaine-dependent, non-treatment-seeking individuals (age=36.6+/-5.9; 75% African American, 25% Caucasian; using cocaine for an average of 15.3+/-6.5 years). Data were collected prior to and following double-blind intravenous administration of 0 mg, 20 mg, and 40 mg of cocaine. Data were collected at baseline, following 5 days of treatment with placebo, and again following 5 days of treatment with a combination of amantadine 100 mg t.i.d. and baclofen 30 mg t.i.d. counterbalanced for order of medication and placebo in a cross-over design. Results showed no significant alterations to cardiovascular variables (heart rate, systolic and diastolic blood pressure) from treatment using combination medication or placebo in the presence of cocaine. Self-rated "desire" for cocaine was significantly lower during cocaine administrations while participants were receiving treatment with amantadine-baclofen compared to infusions while taking placebo medication, although there was no difference in the intensity of cocaine-induced euphoria, or reduction in the likelihood to use cocaine if given access. Study findings support the safety of the amantadine-baclofen combination treatment for cocaine dependence.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Rotheram-Fuller E,De La Garza R 2nd,Mahoney JJ 3rd,Shoptaw S,Newton TFdoi
10.1016/j.psychres.2006.03.012subject
Has Abstractpub_date
2007-08-30 00:00:00pages
205-10issue
2-3eissn
0165-1781issn
1872-7123pii
S0165-1781(06)00085-0journal_volume
152pub_type
杂志文章abstract：:A set of face stimuli called the NimStim Set of Facial Expressions is described. The goal in creating this set was to provide facial expressions that untrained individuals, characteristic of research participants, would recognize. This set is large in number, multiracial, and available to the scientific community onli...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.05.006
更新日期：2009-08-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.04.015
更新日期：2007-08-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.112634
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(89)90036-x
更新日期：1989-08-01 00:00:00
abstract：:The pharmacokinetic properties of platelets make these vascular elements a potential and convenient model for serotoninergic neurons. Because we encountered several difficulties in preliminary platelet serotonin (5HT) uptake assays, we explored the influence of several assay factors on the parameters obtained. We foun...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(87)90051-5
更新日期：1987-09-01 00:00:00
abstract：:Eating disorders (EDs) are characterized by symptoms that reflect disturbed eating habits. Available data on EDs largely reflects a traditional latent variable model, whereby symptoms reflect an underlying entity. The network model is an alternative approach where ED symptoms do not reflect an inferred, unobservable c...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.02.027
更新日期：2018-04-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(00)00239-0
更新日期：2001-02-14 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2009.02.013
更新日期：2010-04-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.11.002
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.05.014
更新日期：2016-07-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2006.02.009
更新日期：2006-08-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.02.048
更新日期：2017-06-01 00:00:00
abstract：:Repetitive transcranial magnetic stimulation (rTMS) is currently undergoing active investigation for use in the treatment of major depression. Recent research has indicated that current methods used to localize the site of stimulation in dorsolateral prefrontal cortex (DLPFC) are significantly inaccurate. However, lit...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析,评审
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更新日期：2006-11-22 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(86)90093-4
更新日期：1986-09-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.10.047
更新日期：2018-12-01 00:00:00
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journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/s0165-1781(99)00014-1
更新日期：1999-03-22 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.11.035
更新日期：2015-02-28 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.04.044
更新日期：2018-07-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.112685
更新日期：2020-02-01 00:00:00
abstract：:Our objective was to study gender differences in delusional disorder (DD), by comparing potential risk factors, clinical correlates, illness course characteristics, and functionality. The sample was composed of 86 outpatients with DD (according to the SCID-I for DSM-IV criteria). The following assessment instruments w...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.02.017
更新日期：2010-05-15 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2010.12.005
更新日期：2011-05-31 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2011.06.004
更新日期：2011-12-30 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2005.11.007
更新日期：2006-05-30 00:00:00
abstract：:N-Acetyl-aspartate (NAA), a marker of neuronal integrity, has been found to be reduced in frontal regions in schizophrenia. However, the impact of antipsychotic drug type on NAA has not been carefully evaluated. We studied outpatients with schizophrenia/schizoaffective disorders chronically treated with haloperidol or...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(01)00102-0
更新日期：2001-10-01 00:00:00
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journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.06.001
更新日期：2013-08-30 00:00:00
abstract：:Recent investigations suggest that serotonergic mechanisms modulate dimensions of personality, in particular decreases in Anger-Hostility and increases in Affiliation. None of these studies, however, demonstrated a specific serotonergic effect on personality, as other neurotransmitter systems have not been assessed fo...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/s0165-1781(99)00041-4
更新日期：1999-06-30 00:00:00
abstract：:Depressive symptoms are common in children and adolescents. The prevalence of depressive symptoms in children and adolescents in China vary significantly across studies. A meta-analysis of the prevalence of depressive symptoms in children and adolescents in China was conducted. Literature search was performed in both ...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.psychres.2018.12.133
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND:Declarative memory disturbances, known to substantially contribute to cognitive impairment in schizophrenia, have previously been attributed to prefrontal as well as hippocampal dysfunction. AIMS:To characterize the role of prefrontal and mesolimbic/hippocampal dysfunction during memory encoding in schizoph...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2010.03.007
更新日期：2010-09-30 00:00:00
abstract：:Patients with schizophrenia show deficits in skill learning. We tested the hypothesis that impaired skill learning is associated with liability for schizophrenia by determining if it is present in non-affected siblings of patients. This study examined cognitive skill learning in adolescent siblings of patients with ch...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.06.009
更新日期：2012-12-30 00:00:00
abstract：:The aims of this study were to: 1) examine the relationship between being bullied and depressive symptoms; 2) explore whether the three mentioned sources of social support moderated this association; and 3) examine gender differences in the moderating effects of social support on bullying-associated depressive symptom...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2019.112676
更新日期：2020-02-01 00:00:00
