Abstract：
BACKGROUND:Declarative memory disturbances, known to substantially contribute to cognitive impairment in schizophrenia, have previously been attributed to prefrontal as well as hippocampal dysfunction. AIMS:To characterize the role of prefrontal and mesolimbic/hippocampal dysfunction during memory encoding in schizophrenia. METHOD:Neuronal activation in schizophrenia patients and controls was assessed using functional magnetic resonance imaging (fMRI) during encoding of words in a deep (semantic judgement) and shallow (case judgment) task. A free recall (no delay) and a recognition task (24h delay) were performed. RESULTS:Free recall, but not recognition performance was reduced in patients. Reduced performance was correlated with positive symptoms which in turn were related to increased left hippocampal activity during successful encoding. Furthermore, schizophrenia patients displayed a hippocampal hyperactivity during deep encoding irrespective of encoding success along with a reduced anterior cingulate cortex (ACC) and dorsomedial prefrontal cortex (DMPFC) activity in successful encoding but an intact left inferior frontal cortex (LIFC) activity. CONCLUSIONS:This study provides the first evidence directly linking positive symptoms and memory deficits to dysfunctional hippocampal hyperactivity. It thereby underscores the pivotal pathophysiological role of a hyperdopaminergic mesolimbic state in schizophrenia.
journal_name
Psychiatry Resjournal_title
Psychiatry researchauthors
Zierhut K,Bogerts B,Schott B,Fenker D,Walter M,Albrecht D,Steiner J,Schütze H,Northoff G,Düzel E,Schiltz Kdoi
10.1016/j.pscychresns.2010.03.007subject
Has Abstractpub_date
2010-09-30 00:00:00pages
187-94issue
3eissn
0165-1781issn
1872-7123pii
S0925-4927(10)00108-3journal_volume
183pub_type
杂志文章abstract：:Only little is known about pathological personality traits in patients with Gilles de la Tourette syndrome (GTS). The aim of this study was to further investigate the prevalence of personality traits in adults with GTS. We used a variety of rating scales to assess not only personality traits, but also severity of tics...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.04.043
更新日期：2015-08-30 00:00:00
abstract：:Previous studies framed a possible link of retinoic acid (RA) regulation in brain to autism spectrum disorders (ASD) etiology. The aim of this study was to measure serum levels of RA in relation to the degree of the severity of autism. Serum RA levels were measured by enzyme-linked immunosorbent assay (ELISA) colorime...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2018.08.091
更新日期：2018-11-01 00:00:00
abstract：:Spouse abuse is listed as a V code in DSM-IV-TR and worthy of further clinical investigation, although research has focused predominantly on the victims of family violence rather than the batterers themselves. This study tests the hypotheses that (a) batterers have a neurocognitive bias favoring negative affect (aggre...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2008.12.013
更新日期：2010-04-30 00:00:00
abstract：:Although psychometrically-defined executive function deficits (EFDs) and ecologically valid functional outcomes have been documented among youth with bipolar I (BP-I) disorder, little is known about their association. We hypothesized that EFDs would be associated with significant ecologically valid impairments beyond ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2010.08.029
更新日期：2011-03-30 00:00:00
abstract：:To clarify the relationship between serum folate and schizophrenia (SZ) risk, the meta-analysis was conducted. PubMed, Embase, and Web of Science were searched without language restrictions. Weighted mean difference (WMD) as a summary statistic was used in this meta-analysis. Subgroup analyses by publication language ...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.psychres.2015.11.045
更新日期：2016-01-30 00:00:00
abstract：:In a review of the current literature, we identified (1)H MRS studies of major depressive disorder (MDD) that examined the metabolites N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), glutamate/glutamine/gamma-aminobutyric acid-GABA (Glx), and creatine (Cr). Separate meta-analyses comparing adult and pediatr...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.pscychresns.2005.12.004
更新日期：2006-06-30 00:00:00
abstract：:Previous studies have identified global associations between sleep quality and suicidal ideation. However, little is known regarding the relationship between sleep quality and suicidal ideation among Chinese older adults. We examined the relationship between sleep quality and suicidal ideation in older adults in China...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.07.017
更新日期：2017-10-01 00:00:00
abstract：:The use of Internet has grown in the past number of years, including the increased application of various therapy programs for psychiatric patients which can be accessed online. Few studies investigating psychiatric patients' Internet use exist. Therefore, the aim of this study was to examine the number of psychiatric...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.12.037
更新日期：2015-03-30 00:00:00
abstract：:Geriatric patients with dementia frequently present with agitation, aggression, psychosis, and other behavioral and psychological symptoms of dementia (BPSD). We present an update of our previously published algorithms for the use of psychopharmacologic agents in these patients taking into account more recent studies ...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2020.113641
更新日期：2021-01-01 00:00:00
abstract：:Imaging studies in patients with Type II alcohol dependence have revealed significant reductions in dopamine (DA) D2 receptor availability. Here we assessed the effects of alcohol detoxification in DA D2 receptors in alcoholic subjects. We evaluated 14 patients with Type II alcohol dependence tested within 6 weeks of ...
journal_title：Psychiatry research
pub_type： 临床试验,杂志文章
doi：10.1016/s0925-4927(02)00087-2
更新日期：2002-12-30 00:00:00
abstract：:Depressive symptoms are common in children and adolescents. The prevalence of depressive symptoms in children and adolescents in China vary significantly across studies. A meta-analysis of the prevalence of depressive symptoms in children and adolescents in China was conducted. Literature search was performed in both ...
journal_title：Psychiatry research
pub_type： 杂志文章,meta分析
doi：10.1016/j.psychres.2018.12.133
更新日期：2019-02-01 00:00:00
abstract：:Accurate drug use assessment is vital to understanding the prevalence, course, treatment needs, and outcomes among individuals with schizophrenia because they are thought to remain at long-term risk for negative drug use outcomes, even in the absence of drug use disorder. This study evaluated self-report and biologica...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2012.05.028
更新日期：2012-12-30 00:00:00
abstract：:The aim of this study was to investigate theory of mind (ToM) in a sample of depressed patients with mild symptom severity using a measure with varied cognitive processing demands. Patients demonstrated impaired performance on second-order, cognitively demanding ToM scenarios. Reduced ToM ability was associated with p...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2013.06.018
更新日期：2013-12-15 00:00:00
abstract：:Disorders of the basal ganglia (BG) alter perception and experience of emotions. Left hemisphere BG (LBG) stroke is also associated with depression. The interplay between depression and alterations in emotional processing following LBG stroke was examined. Evoked affective responses to emotion-laden pictorial stimuli ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2012.05.008
更新日期：2013-02-28 00:00:00
abstract：:Depression is a common illness which tends to have a relapsing progression. Revealing vulnerability factors is an important step towards improved treatment and prevention. Previous studies of individuals in remission indicate that inhibitory control is more strongly impaired than other cognitive functions. Studies hav...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.11.038
更新日期：2016-01-30 00:00:00
abstract：:Neuroimaging studies indicate diminished lateralisation of cerebral activity during motor tasks and language processing in schizophrenia. Some evidence also indicates that decreased lateralisation is accompanied by more diffuse intra-hemispheric activation, suggesting that diminished lateralisation might be part of a ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.pscychresns.2009.04.004
更新日期：2009-10-30 00:00:00
abstract：:Social functioning is a conglomerate of factors central to clinical recovery after a first-episode psychosis. There is a lack of studies investigating the relative impact of factors related to social interaction. Disentangling these could facilitate improvement of psychosocial interventions. This study aims to investi...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2017.05.041
更新日期：2017-09-01 00:00:00
abstract：:The seven-factor model of personality developed by Cloninger and colleagues describes personality as a function of developmental aspects of character superimposed on heritable dimensions of temperament. The objective of this study was to determine whether this model could be applied to early childhood. We tested a pre...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(02)00008-2
更新日期：2002-04-15 00:00:00
abstract：:The covid-19 pandemic has heavily burdened healthcare systems throughout the world. We performed a rapid systematic review to identify, assess and summarize research on the mental health impact of the covid-19 pandemic on HCWs (healthcare workers). We utilized the Norwegian Institute of Public Health's Live map of cov...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113441
更新日期：2020-11-01 00:00:00
abstract：:Semantically incoherent speech is a pernicious clinical feature of serious mental illness (SMI). The precise mechanisms underlying this deficit remain unclear. Prior studies have found that arousal of negative emotion exaggerates the severity of these communication disturbances; this has been coined "affective reactiv...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2016.12.025
更新日期：2017-02-01 00:00:00
abstract：:We evaluated the effects of repeated subanesthetic ketamine infusions on suicidal ideation (SI) in patients with major depression. 82 subjects with treatment-resistant unipolar and bipolar depression completed a two-site open-label case-series of repeated (up to four weeks) infusions of ketamine (0.5 mg/kg). Ketamine ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113645
更新日期：2020-12-16 00:00:00
abstract：:Attentional and executive impairments have been found both in patients with schizophrenia and in their unaffected first-degree relatives, suggesting that they might be considered as familial vulnerability markers. Several studies have shown that the performance of bipolar patients does not significantly differ from th...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0165-1781(03)00252-x
更新日期：2004-01-01 00:00:00
abstract：:The significance of neurological signs in schizophrenia is poorly understood. In part, this may reflect the marked variability in the methods of ascertainment in previous studies. The Neurological Evaluation Scale (NES) is designed to standardize the assessment of neurological impairment in schizophrenia. The battery ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(89)90148-0
更新日期：1989-03-01 00:00:00
abstract：:Recent findings support the role of purinergic system dysfunction in the pathophysiology of bipolar disorder (BD). The present study aimed to evaluate the pattern of serum uric acid levels in a sample of 98 BD I patients followed-up prospectively in a naturalistic study and treated with lithium monotherapy or in assoc...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2014.11.038
更新日期：2015-02-28 00:00:00
abstract：:Absence of the adhesio interthalamica (AI) in schizophrenic first episode patients is suggestive for another marker of early developmental neuropathologic changes. Moreover, findings suggest that schizophrenic patients without AI are characterised by more severe negative symptoms. The study aims to investigate the pre...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/s0925-4927(02)00044-6
更新日期：2002-10-01 00:00:00
abstract：:Pathological gamblers (PGs) perform differently on neurocognitive tests than do healthy controls (HC). The aim of this study was to assess "waiting ability" - a major components of inhibition control-using a modified Stop Signal Task (SST) in a population of male PGs (N=55), and HCs (N=53). Results indicated no differ...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2015.09.038
更新日期：2015-12-15 00:00:00
abstract：:Implementation science is focused on maximizing the adoption, appropriate use, and sustainability of effective clinical practices in real world clinical settings. Many implementation science questions can be feasibly answered by fully experimental designs, typically in the form of randomized controlled trials (RCTs). ...
journal_title：Psychiatry research
pub_type： 杂志文章,评审
doi：10.1016/j.psychres.2019.06.027
更新日期：2020-01-01 00:00:00
abstract：:Sleep-related prolactin secretion and prolactin responses to the infusion of low doses of the dopamine antagonist, metoclopramide, and thyrotropin-releasing hormone were measured in 11 female volunteers before and after undertaking a diet in which they lost a mean of 3.1 kg in weight in 3 weeks. No effect of weight lo...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(89)90030-9
更新日期：1989-08-01 00:00:00
abstract：:Recent studies have implicated dopamine and the basal ganglia circuits in the pathophysiology of social phobia. Twenty-two patients who met DSM-III-R criteria for social phobia and 22 age- and sex-matched control subjects underwent magnetic resonance imaging (MRI). MRI was performed with a 1.5 Tesla General Electric S...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/0165-1781(94)90118-x
更新日期：1994-04-01 00:00:00
abstract：:The utility of non-invasive brain stimulation techniques to alleviate resistant delusions in schizophrenia is an under-researched area. In this study, we report the effectiveness of alpha transcranial alternating current stimulation (tACS) targeting the medial prefrontal cortex in ameliorating persistent delusions. Tw...
journal_title：Psychiatry research
pub_type： 杂志文章
doi：10.1016/j.psychres.2020.113106
更新日期：2020-08-01 00:00:00
