Autonomic effects of dextroamphetamine in normal men: implications for hyperactivity and schizophrenia.

Abstract:

:This study test the effects on autonomic nervous system (ANS) activity of two doses (0.25 mg/kg and 0.50 mg/kg) of dextroamphetamine in normal men. Skin conductance and heart rate were recorded during rest, tone presentation, and a reaction time task. Compared to placebo, dextroamphetamine increased both skin conductance and heart rate indices of arousal, slowed habituation, and reduced ANS responsivity selectively to more important vs. less important stimuli. The last result differs from previous findings on hyperactive and normal boys. The pattern of ANS effects closely resembles findings on drug-free schizophrenics, suggesting that it may be a matter for biologic changes occurring in amphetamine psychosis and spontaneous psychotic episodes.

journal_name

Psychiatry Res

journal_title

Psychiatry research

authors

Zahn TP,Rapoport JL,Thompson CL

doi

10.1016/0165-1781(81)90006-8

subject

Has Abstract

pub_date

1981-02-01 00:00:00

pages

39-47

issue

1

eissn

0165-1781

issn

1872-7123

pii

0165-1781(81)90006-8

journal_volume

4

pub_type

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